MOUSE:UCHL1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Uchl1
Protein Name(s)	Ubiquitin carboxyl-terminal hydrolase isozyme L1 UCH-L1 Neuron cytoplasmic protein 9.5 PGP 9.5 PGP9.5 Ubiquitin thioesterase L1
External Links
UniProt	Q9R0P9
EMBL	AB025313 AF172334 AK013729 BC039177
CCDS	CCDS19315.1
RefSeq	NP_035800.2
UniGene	Mm.29807
ProteinModelPortal	Q9R0P9
SMR	Q9R0P9
BioGrid	204423
IntAct	Q9R0P9
MINT	MINT-4139420
STRING	10090.ENSMUSP00000031131
BindingDB	Q9R0P9
MEROPS	C12.001
PhosphoSite	Q9R0P9
REPRODUCTION-2DPAGE	IPI00313962 Q9R0P9
UCD-2DPAGE	Q9R0P9
MaxQB	Q9R0P9
PaxDb	Q9R0P9
PRIDE	Q9R0P9
Ensembl	ENSMUST00000031131
GeneID	22223
KEGG	mmu:22223
UCSC	uc008xpf.2
CTD	7345
MGI	MGI:103149
eggNOG	NOG327708
GeneTree	ENSGT00510000046640
HOVERGEN	HBG075483
InParanoid	Q9R0P9
KO	K05611
OMA	MEWKPME
OrthoDB	EOG7S7SFK
PhylomeDB	Q9R0P9
TreeFam	TF316166
BRENDA	3.4.19.12
ChiTaRS	Uchl1
NextBio	302243
PRO	PR:Q9R0P9
Proteomes	UP000000589
Bgee	Q9R0P9
CleanEx	MM_UCHL1
ExpressionAtlas	Q9R0P9
Genevestigator	Q9R0P9
GO	GO:0030424 GO:0005737 GO:0005829 GO:0005789 GO:0070062 GO:0043025 GO:0005634 GO:0005886 GO:0004197 GO:0016874 GO:0008242 GO:0043130 GO:0004221 GO:0004843 GO:0007628 GO:0007412 GO:0019896 GO:0007409 GO:0008283 GO:0042755 GO:0048747 GO:0043407 GO:0050905 GO:0016579 GO:0002931 GO:0019233 GO:0006511
Gene3D	3.40.532.10
InterPro	IPR001578 IPR030297
PANTHER	PTHR10589 PTHR10589:SF19
Pfam	PF01088
PRINTS	PR00707
PROSITE	PS00140

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	PMID:25466238^[1]	ECO:0000314			P		Figure 2 shows UCHL 1 reduces the level of mature APP protein	complete CACAO 10616
	GO:0042984	regulation of amyloid precursor protein biosynthetic process	PMID:25466238^[1]	ECO:0000314			P		Figure 1 shows UCHL 1 regulates APP processing	complete CACAO 10617
part_of	GO:0043209	myelin sheath	PMID:17634366^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000128)	Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09936	F		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09936	P		Seeded From UniProt	complete
enables	GO:0008242	omega peptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09936	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12913066^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P09936	F		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010288 FB:FBgn0011327 MGI:MGI:1355274 PANTHER:PTN000063280 UniProtKB:P09936 UniProtKB:P15374 UniProtKB:Q8IIJ6 UniProtKB:Q8IKM8 UniProtKB:Q92560 UniProtKB:Q9Y5K5	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:103149 PANTHER:PTN000063280 TAIR:locus:2171312 UniProtKB:P09936 UniProtKB:Q92560	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010288 FB:FBgn0011327 FB:FBgn0262166 MGI:MGI:103149 PANTHER:PTN000063280 PomBase:SPBC409.06 SGD:S000003860 TAIR:locus:2018516 UniProtKB:P09936 UniProtKB:P15374 UniProtKB:Q92560 UniProtKB:Q9Y5K5	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050905	neuromuscular process	PMID:7555927^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856882	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050905	neuromuscular process	PMID:3340629^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856882	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048747	muscle fiber development	PMID:8007658^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:94909	P		Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	PMID:24760869^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	PMID:12913066^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	F		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:23284756^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17607)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:11549719^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16668) part_of:(CL:0000540)\|part_of:(EMAPA:17576) part_of:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042755	eating behavior	PMID:11555633^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1355274	P		Seeded From UniProt	complete
enables	GO:0031694	alpha-2A adrenergic receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:8896700^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18271) part_of:(CL:0000540)\|part_of:(EMAPA:18271) part_of:(CL:0000540)\|part_of:(EMAPA:18654) part_of:(CL:0000540)\|part_of:(EMAPA:18871) part_of:(CL:0000540)\|part_of:(EMAPA:18871) part_of:(CL:0000540)\|part_of:(EMAPA:18871) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21606356^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16853)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:14973275^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16665) part_of:(CL:0000111)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:12866128^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17881) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:12107488^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17637) part_of:(CL:0000111)\|part_of:(EMAPA:17356) part_of:(CL:0000111)\|part_of:(EMAPA:17917) part_of:(CL:0000111)\|part_of:(EMAPA:17938) part_of:(CL:0000111)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:12074562^[17]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:19211) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:11466438^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:18321) part_of:(CL:0000101)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019896	axonal transport of mitochondrion	PMID:2558488^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856882	P	occurs_in:(EMAPA:36231) occurs_in:(CL:0000101)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3928	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016579	protein deubiquitination	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:12638230^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856882	P	occurs_in:(EMAPA:17972) acts_on_population_of:(CL:0000020)\|occurs_in(EMAPA:17972) acts_on_population_of:(CL:0000656)	Seeded From UniProt	complete
enables	GO:0008242	omega peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:11555633^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1355274	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:3340629^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856882	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007628	adult walking behavior	PMID:11555633^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856882	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007412	axon target recognition	PMID:8474599^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856882	P	occurs_in:(EMAPA:36231)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007409	axonogenesis	PMID:1630580^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856882	P	occurs_in:(EMAPA:36231) occurs_in:(CL:0000101)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3928	P		Seeded From UniProt	complete
colocalizes_with	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12913066^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	PMID:12913066^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P09936	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002931	response to ischemia	PMID:14695319^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856882	P	occurs_in:(EMAPA:17168)	Seeded From UniProt	complete
part_of	GO:1904115	axon cytoplasm	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0019896	C		Seeded From UniProt	complete
involved_in	GO:0043407	negative regulation of MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	F		Seeded From UniProt	complete
enables	GO:0031694	alpha-2A adrenergic receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	F		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	P		Seeded From UniProt	complete
enables	GO:0008242	omega peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P09936 ensembl:ENSP00000284440	F		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00981 ensembl:ENSRNOP00000003248	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q00981 ensembl:ENSRNOP00000003248	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HW74 ensembl:ENSP00000284440	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:V9HW74 ensembl:ENSP00000284440	C		Seeded From UniProt	complete
enables	GO:0004843	thiol-dependent ubiquitin-specific protease activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001578 InterPro:IPR036959	F		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001578 InterPro:IPR036959	P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030297	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030297	F		Seeded From UniProt	complete
enables	GO:0016874	ligase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR030297	F		Seeded From UniProt	complete
enables	GO:0036459	thiol-dependent ubiquitinyl hydrolase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.4.19.12	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Zhang, M et al. (2014) Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo. Sci Rep 4 7298 PubMed GONUTS page
↑ Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Osaka, H et al. (2003) Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum. Mol. Genet. 12 1945-58 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Chandran, AP et al. () Stimulus induced repetitive muscle potentials in the gracile axonal dystrophy (GAD) mouse. Electromyogr Clin Neurophysiol 35 225-30 PubMed GONUTS page
↑ ^6.0 ^6.1 Yamazaki, K et al. (1988) Gracile axonal dystrophy (GAD), a new neurological mutant in the mouse. Proc. Soc. Exp. Biol. Med. 187 209-15 PubMed GONUTS page
↑ Suh, JG et al. (1994) Breeding of the gad-mdx mouse: influence of genetically induced denervation on dystrophic muscle fibers. Lab. Anim. Sci. 44 42-6 PubMed GONUTS page
↑ Yu, T et al. (2014) In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J. Neurosci. 34 6098-106 PubMed GONUTS page
↑ Krolewski, RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS ONE 7 e51737 PubMed GONUTS page
↑ Simpson, MT et al. (2001) Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J. Neurosci. 21 7089-98 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Kurihara, LJ et al. (2001) Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Hum. Mol. Genet. 10 1963-70 PubMed GONUTS page
↑ Wakisaka, S et al. (1996) Protein gene-product 9.5 in developing mouse circumvallate papilla: comparison with neuron-specific enolase and calcitonin gene-related peptide. Anat. Embryol. 194 365-72 PubMed GONUTS page
↑ Krasteva, G et al. (2011) Cholinergic chemosensory cells in the trachea regulate breathing. Proc. Natl. Acad. Sci. U.S.A. 108 9478-83 PubMed GONUTS page
↑ Guha, U et al. (2004) Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo. Development 131 1175-86 PubMed GONUTS page
↑ Seta, Y et al. (2003) Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions. J. Comp. Neurol. 464 49-61 PubMed GONUTS page
↑ Løes, S et al. (2002) Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibers. Anat. Embryol. 205 187-91 PubMed GONUTS page
↑ Kameda, Y et al. (2002) Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos. Dev. Biol. 247 197-209 PubMed GONUTS page
↑ Vlaskovska, M et al. (2001) P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J. Neurosci. 21 5670-7 PubMed GONUTS page
↑ Mukoyama, M et al. (1989) Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons. Acta Neuropathol. 79 294-9 PubMed GONUTS page
↑ Kwon, J et al. (2003) Characterization of the testis in congenitally ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) defective (gad) mice. Exp. Anim. 52 1-9 PubMed GONUTS page
↑ Miura, H et al. (1993) Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy. Neuropathol. Appl. Neurobiol. 19 41-51 PubMed GONUTS page
↑ Oda, K et al. (1992) Dying back type axonal degeneration of sensory nerve terminals in muscle spindles of the gracile axonal dystrophy (GAD) mutant mouse. Neuropathol. Appl. Neurobiol. 18 265-81 PubMed GONUTS page
↑ Harada, T et al. (2004) Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo. Am. J. Pathol. 164 59-64 PubMed GONUTS page

[PMID:25466238-1] 1.0 ^1.1 Zhang, M et al. (2014) Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo. Sci Rep 4 7298 PubMed GONUTS page

[PMID:17634366-2] Werner, HB et al. (2007) Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. J. Neurosci. 27 7717-30 PubMed GONUTS page

[PMID:12913066-3] 3.0 ^3.1 ^3.2 ^3.3 Osaka, H et al. (2003) Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum. Mol. Genet. 12 1945-58 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:7555927-5] Chandran, AP et al. () Stimulus induced repetitive muscle potentials in the gracile axonal dystrophy (GAD) mouse. Electromyogr Clin Neurophysiol 35 225-30 PubMed GONUTS page

[PMID:3340629-6] 6.0 ^6.1 Yamazaki, K et al. (1988) Gracile axonal dystrophy (GAD), a new neurological mutant in the mouse. Proc. Soc. Exp. Biol. Med. 187 209-15 PubMed GONUTS page

[PMID:8007658-7] Suh, JG et al. (1994) Breeding of the gad-mdx mouse: influence of genetically induced denervation on dystrophic muscle fibers. Lab. Anim. Sci. 44 42-6 PubMed GONUTS page

[PMID:24760869-8] Yu, T et al. (2014) In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J. Neurosci. 34 6098-106 PubMed GONUTS page

[PMID:23284756-9] Krolewski, RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS ONE 7 e51737 PubMed GONUTS page

[PMID:11549719-10] Simpson, MT et al. (2001) Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice. J. Neurosci. 21 7089-98 PubMed GONUTS page

[PMID:11555633-11] 11.0 ^11.1 ^11.2 Kurihara, LJ et al. (2001) Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Hum. Mol. Genet. 10 1963-70 PubMed GONUTS page

[PMID:8896700-12] Wakisaka, S et al. (1996) Protein gene-product 9.5 in developing mouse circumvallate papilla: comparison with neuron-specific enolase and calcitonin gene-related peptide. Anat. Embryol. 194 365-72 PubMed GONUTS page

[PMID:21606356-13] Krasteva, G et al. (2011) Cholinergic chemosensory cells in the trachea regulate breathing. Proc. Natl. Acad. Sci. U.S.A. 108 9478-83 PubMed GONUTS page

[PMID:14973275-14] Guha, U et al. (2004) Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo. Development 131 1175-86 PubMed GONUTS page

[PMID:12866128-15] Seta, Y et al. (2003) Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions. J. Comp. Neurol. 464 49-61 PubMed GONUTS page

[PMID:12107488-16] Løes, S et al. (2002) Mouse rudimentary diastema tooth primordia are devoid of peripheral nerve fibers. Anat. Embryol. 205 187-91 PubMed GONUTS page

[PMID:12074562-17] Kameda, Y et al. (2002) Homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos. Dev. Biol. 247 197-209 PubMed GONUTS page

[PMID:11466438-18] Vlaskovska, M et al. (2001) P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J. Neurosci. 21 5670-7 PubMed GONUTS page

[PMID:2558488-19] Mukoyama, M et al. (1989) Neuropathology of gracile axonal dystrophy (GAD) mouse. An animal model of central distal axonopathy in primary sensory neurons. Acta Neuropathol. 79 294-9 PubMed GONUTS page

[PMID:12638230-20] Kwon, J et al. (2003) Characterization of the testis in congenitally ubiquitin carboxy-terminal hydrolase-1 (Uch-L1) defective (gad) mice. Exp. Anim. 52 1-9 PubMed GONUTS page

[PMID:8474599-21] Miura, H et al. (1993) Progressive degeneration of motor nerve terminals in GAD mutant mouse with hereditary sensory axonopathy. Neuropathol. Appl. Neurobiol. 19 41-51 PubMed GONUTS page

[PMID:1630580-22] Oda, K et al. (1992) Dying back type axonal degeneration of sensory nerve terminals in muscle spindles of the gracile axonal dystrophy (GAD) mutant mouse. Neuropathol. Appl. Neurobiol. 18 265-81 PubMed GONUTS page

[PMID:14695319-23] Harada, T et al. (2004) Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo. Am. J. Pathol. 164 59-64 PubMed GONUTS page

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MOUSE:UCHL1

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