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HUMAN:ABCE1
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | ABCE1 (synonyms: RLI, RNASEL1, RNASELI, RNS4I) | |
| Protein Name(s) | ATP-binding cassette sub-family E member 1
2'-5'-oligoadenylate-binding protein HuHP68 RNase L inhibitor Ribonuclease 4 inhibitor RNS4I | |
| External Links | ||
| UniProt | P61221 | |
| EMBL | X76388 X74987 AB062293 BT009779 DQ148409 BC016283 BC016988 | |
| CCDS | CCDS34071.1 | |
| PIR | A57017 S63672 | |
| RefSeq | NP_001035809.1 NP_002931.2 | |
| UniGene | Hs.12013 | |
| ProteinModelPortal | P61221 | |
| SMR | P61221 | |
| BioGrid | 111986 | |
| IntAct | P61221 | |
| MINT | MINT-5004380 | |
| STRING | 9606.ENSP00000296577 | |
| PhosphoSite | P61221 | |
| DMDM | 47117664 | |
| MaxQB | P61221 | |
| PaxDb | P61221 | |
| PeptideAtlas | P61221 | |
| PRIDE | P61221 | |
| DNASU | 6059 | |
| Ensembl | ENST00000296577 | |
| GeneID | 6059 | |
| KEGG | hsa:6059 | |
| UCSC | uc003ijx.3 | |
| CTD | 6059 | |
| GeneCards | GC04P146019 | |
| HGNC | HGNC:69 | |
| HPA | CAB012476 | |
| MIM | 601213 | |
| neXtProt | NX_P61221 | |
| PharmGKB | PA24404 | |
| eggNOG | COG1245 | |
| GeneTree | ENSGT00390000015089 | |
| HOVERGEN | HBG050439 | |
| InParanoid | P61221 | |
| KO | K06174 | |
| OMA | ISYKPQY | |
| OrthoDB | EOG70GMF4 | |
| PhylomeDB | P61221 | |
| TreeFam | TF105206 | |
| ChiTaRS | ABCE1 | |
| GenomeRNAi | 6059 | |
| NextBio | 23613 | |
| PRO | PR:P61221 | |
| Proteomes | UP000005640 | |
| Bgee | P61221 | |
| CleanEx | HS_ABCE1 | |
| ExpressionAtlas | P61221 | |
| Genevestigator | P61221 | |
| GO | GO:0005737 GO:0016020 GO:0005739 GO:0005524 GO:0016887 GO:0051536 GO:0008428 GO:0043086 GO:0009615 GO:0006401 GO:0016032 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR001450 IPR017896 IPR017900 IPR003593 IPR003439 IPR017871 IPR013283 IPR027417 IPR007209 | |
| PANTHER | PTHR19248 | |
| Pfam | PF00005 PF00037 PF04068 | |
| PRINTS | PR01868 | |
| SMART | SM00382 | |
| SUPFAM | SSF52540 | |
| PROSITE | PS00198 PS51379 PS00211 PS50893 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0008428 |
ribonuclease inhibitor activity |
ECO:0000314 |
F |
Fig 1. ABCE1 suppresses RNAi of GFP in N. benthamiana. Fig 2. Northern blot analysis showing the suppression of GFP RNA silencing in N. benthamiana by ABCE1 |
complete | |||||
|
part_of |
GO:0016020 |
membrane |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0060698 |
endoribonuclease inhibitor activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060702 |
negative regulation of endoribonuclease activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0043024 |
ribosomal small subunit binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0086706 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006415 |
translational termination |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000443727 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0086706 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0086706 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0005506 |
iron ion binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000443727 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0000054 |
ribosomal subunit export from nucleus |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000443727 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016887 |
ATPase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0060338 |
regulation of type I interferon-mediated signaling pathway |
Reactome:R-HSA-5223305 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0051607 |
defense response to virus |
Reactome:R-HSA-8983711 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-HSA-8985201 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005759 |
mitochondrial matrix |
Reactome:R-HSA-5223305 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kärblane, K et al. (2015) ABCE1 is a highly conserved RNA silencing suppressor. PLoS ONE 10 e0116702 PubMed GONUTS page
- ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
- ↑ 3.0 3.1 Bisbal, C et al. (1995) Cloning and characterization of a RNAse L inhibitor. A new component of the interferon-regulated 2-5A pathway. J. Biol. Chem. 270 13308-17 PubMed GONUTS page
- ↑ 4.0 4.1 Le Roy, F et al. (2001) The 2-5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. J. Biol. Chem. 276 48473-82 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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