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HUMAN:MASP1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) MASP1 (synonyms: CRARF, CRARF1, PRSS5)
Protein Name(s) Mannan-binding lectin serine protease 1

Complement factor MASP-3 Complement-activating component of Ra-reactive factor Mannose-binding lectin-associated serine protease 1 MASP-1 Mannose-binding protein-associated serine protease Ra-reactive factor serine protease p100 RaRF Serine protease 5 Mannan-binding lectin serine protease 1 heavy chain Mannan-binding lectin serine protease 1 light chain

External Links
UniProt P48740
EMBL D17525
D28593
D61695
AB007617
AF284421
AK291157
AK291686
AK304334
CR749615
AC007920
CH471052
BC039724
BC106945
BC106946
CCDS CCDS33907.1
CCDS33908.1
CCDS33909.1
PIR I54763
RefSeq NP_001027019.1
NP_001870.3
NP_624302.1
UniGene Hs.89983
PDB 3DEM
3GOV
4AQB
4DJZ
4IGD
4IW4
4KKD
PDBsum 3DEM
3GOV
4AQB
4DJZ
4IGD
4IW4
4KKD
ProteinModelPortal P48740
SMR P48740
BioGrid 111629
IntAct P48740
MINT MINT-4657209
MEROPS S01.132
PhosphoSite P48740
DMDM 218512135
PaxDb P48740
PRIDE P48740
Ensembl ENST00000169293
ENST00000296280
ENST00000337774
ENST00000392472
GeneID 5648
KEGG hsa:5648
UCSC uc003frh.2
uc003fri.3
uc003frk.2
CTD 5648
GeneCards GC03M186935
HGNC HGNC:6901
HPA HPA001617
HPA009641
MIM 257920
600521
neXtProt NX_P48740
Orphanet 293843
PharmGKB PA30644
eggNOG COG5640
GeneTree ENSGT00760000118890
HOVERGEN HBG000559
InParanoid P48740
KO K03992
OMA VWEQMGS
OrthoDB EOG7W6WK4
PhylomeDB P48740
TreeFam TF330373
Reactome REACT_163699
REACT_163810
REACT_7964
REACT_8024
SABIO-RK P48740
ChiTaRS MASP1
EvolutionaryTrace P48740
GeneWiki MASP1_(protein)
GenomeRNAi 5648
NextBio 21938
PMAP-CutDB Q96RS4
PRO PR:P48740
Proteomes UP000005640
Bgee P48740
CleanEx HS_MASP1
ExpressionAtlas P48740
Genevestigator P48740
GO GO:0005576
GO:0005615
GO:0005509
GO:0048306
GO:0008233
GO:0042803
GO:0004252
GO:0006956
GO:0001867
GO:0045087
GO:0045916
Gene3D 2.60.120.290
InterPro IPR000859
IPR001881
IPR013032
IPR018097
IPR024175
IPR001254
IPR018114
IPR001314
IPR000436
IPR009003
Pfam PF00431
PF07645
PF00084
PF00089
PIRSF PIRSF001155
PRINTS PR00722
SMART SM00032
SM00042
SM00179
SM00020
SUPFAM SSF49854
SSF50494
SSF57535
PROSITE PS00010
PS01180
PS01186
PS01187
PS50923
PS50240
PS00134
PS00135

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0048306

calcium-dependent protein binding

PMID:18596036[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P11226

F

Seeded From UniProt

complete

enables

GO:0048306

calcium-dependent protein binding

PMID:12421953[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15485

F

Seeded From UniProt

complete

enables

GO:0048306

calcium-dependent protein binding

PMID:12421953[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P11226

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:18596036[1]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P48740

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

PMID:12538697[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

PMID:10946292[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:11485744[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

PMID:18596036[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

GO:0008236

serine-type peptidase activity

PMID:25617734[6]

ECO:0000314

F

A cell wall component as well as serine synthesizer

complete
CACAO 10578

enables

GO:0004252

serine-type endopeptidase activity

PMID:11527969[7]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

PMID:17182967[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:2660692
MGI:MGI:88492
PANTHER:PTN001207255
RGD:2825
RGD:620213
UniProtKB:P00736
UniProtKB:P00738
UniProtKB:P48740

C

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88492
PANTHER:PTN001207255
RGD:620213
RGD:620214
UniProtKB:O00187
UniProtKB:P00736
UniProtKB:P09871
UniProtKB:P48740

F

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88492
PANTHER:PTN000668948
UniProtKB:P48740

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005615

extracellular space

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P98064
ensembl:ENSMUSP00000087327

C

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P98064
ensembl:ENSMUSP00000087327

F

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P98064
ensembl:ENSMUSP00000087327

P

Seeded From UniProt

complete

enables

GO:0004252

serine-type endopeptidase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

F

Seeded From UniProt

complete

enables

GO:0005509

calcium ion binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001881
InterPro:IPR018097

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001254
InterPro:IPR001314
InterPro:IPR018114

P

Seeded From UniProt

complete

involved_in

GO:0045916

negative regulation of complement activation

PMID:11485744[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006956

complement activation

Reactome:R-HSA-166663

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006898

receptor-mediated endocytosis

Reactome:R-HSA-3000480

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-8852509
Reactome:R-HSA-2855125
Reactome:R-HSA-2855077
Reactome:R-HSA-2855054
Reactome:R-HSA-2203480
Reactome:R-HSA-166792
Reactome:R-HSA-166753
Reactome:R-HSA-166726
Reactome:R-HSA-166721

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

Reactome:R-HSA-2855086
Reactome:R-HSA-166662

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

enables

GO:0008233

peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

F

Seeded From UniProt

complete

involved_in

GO:0006508

proteolysis

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0645

P

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0964
UniProtKB-SubCell:SL-0243

C

Seeded From UniProt

complete

enables

GO:0008236

serine-type peptidase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0720

F

Seeded From UniProt

complete

involved_in

GO:0001867

complement activation, lectin pathway

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1018

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Teillet, F et al. (2008) Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J. Biol. Chem. 283 25715-24 PubMed GONUTS page
  2. ↑ 2.0 2.1 Cseh, S et al. (2002) Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J. Immunol. 169 5735-43 PubMed GONUTS page
  3. ↑ Ambrus, G et al. (2003) Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments. J. Immunol. 170 1374-82 PubMed GONUTS page
  4. ↑ Matsushita, M et al. (2000) Proteolytic activities of two types of mannose-binding lectin-associated serine protease. J. Immunol. 165 2637-42 PubMed GONUTS page
  5. ↑ 5.0 5.1 Dahl, MR et al. (2001) MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 15 127-35 PubMed GONUTS page
  6. ↑ Pärnänen, P et al. (2015) A novel Candida glabrata cell wall associated serine protease. Biochem. Biophys. Res. Commun. 457 676-80 PubMed GONUTS page
  7. ↑ Rossi, V et al. (2001) Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2. J. Biol. Chem. 276 40880-7 PubMed GONUTS page
  8. ↑ Møller-Kristensen, M et al. (2007) Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway. Int. Immunol. 19 141-9 PubMed GONUTS page
  9. ↑ 9.0 9.1 9.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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