HUMAN:CO3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	C3 (synonyms: CPAMD1)
Protein Name(s)	Complement C3 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1 Complement C3 beta chain C3-beta-c C3bc Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein ASP C3adesArg Complement C3b alpha' chain Complement C3c alpha' chain fragment 1 Complement C3dg fragment Complement C3g fragment Complement C3d fragment Complement C3f fragment Complement C3c alpha' chain fragment 2
External Links
UniProt	P01024
EMBL	K02765 AY513239 CH471139 BC150179 BC150200
CCDS	CCDS32883.1
PIR	A94065
RefSeq	NP_000055.2
UniGene	Hs.529053
PDB	1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2HR0 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76
PDBsum	1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2HR0 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76
ProteinModelPortal	P01024
SMR	P01024
BioGrid	107179
DIP	DIP-35180N
IntAct	P01024
MINT	MINT-5003988
STRING	9606.ENSP00000245907
BindingDB	P01024
ChEMBL	CHEMBL4917
DrugBank	DB00028
MEROPS	I39.950
PhosphoSite	P01024
UniCarbKB	P01024
DMDM	119370332
DOSAC-COBS-2DPAGE	P01024
SWISS-2DPAGE	P01024
MaxQB	P01024
PaxDb	P01024
PeptideAtlas	P01024
PRIDE	P01024
Ensembl	ENST00000245907
GeneID	718
KEGG	hsa:718
UCSC	uc002mfm.3
CTD	718
GeneCards	GC19M006677
GeneReviews	C3
H-InvDB	HIX0020036
HGNC	HGNC:1318
HPA	CAB004209 HPA003563 HPA020432
MIM	120700 611378 612925 613779
neXtProt	NX_P01024
Orphanet	279 93575 280133
PharmGKB	PA25897
eggNOG	NOG241555
HOGENOM	HOG000286028
HOVERGEN	HBG005110
InParanoid	P01024
KO	K03990
OMA	PGMPFDL
OrthoDB	EOG77HDCX
PhylomeDB	P01024
TreeFam	TF313285
Reactome	REACT_11152 REACT_118707 REACT_14819 REACT_19231 REACT_7972 REACT_8001
ChiTaRS	C3
EvolutionaryTrace	P01024
GeneWiki	Complement_component_3
GenomeRNAi	718
NextBio	2922
PMAP-CutDB	P01024
PRO	PR:P01024
Proteomes	UP000005640
Bgee	P01024
CleanEx	HS_C3
ExpressionAtlas	P01024
Genevestigator	P01024
GO	GO:0072562 GO:0005576 GO:0005615 GO:0070062 GO:0005886 GO:0031715 GO:0004866 GO:0005102 GO:0006956 GO:0006957 GO:0006958 GO:0006631 GO:0007186 GO:0006955 GO:0006954 GO:0045087 GO:0001970 GO:0045766 GO:2000427 GO:0045745 GO:0010828 GO:0010884 GO:0001934 GO:0001798 GO:0010575 GO:0030449 GO:0050776 GO:0010866 GO:0007165
Gene3D	1.20.91.20 1.50.10.20 2.60.40.690
InterPro	IPR009048 IPR011626 IPR002890 IPR011625 IPR000020 IPR018081 IPR001840 IPR001599 IPR019742 IPR019565 IPR001134 IPR018933 IPR008930 IPR008993
Pfam	PF00207 PF07678 PF01835 PF07703 PF07677 PF01821 PF01759 PF10569
PRINTS	PR00004
SMART	SM00104 SM00643
SUPFAM	SSF47686 SSF48239 SSF49410 SSF50242
PROSITE	PS00477 PS01177 PS01178 PS50189

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060100	positive regulation of phagocytosis, engulfment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01027	P	has_regulation_target:(GO:0106003) has_regulation_target:(UniProtKB:P05067:PRO_0000000092) occurs_in:(CL:0000129) part_of:(GO:0097242)	Seeded From UniProt	complete
involved_in	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01027	P	has_regulation_target:(GO:0106003) has_regulation_target:(UniProtKB:P05067:PRO_0000000092) occurs_in:(CL:0000129) part_of:(GO:0097242)	Seeded From UniProt	complete
involved_in	GO:0150064	vertebrate eye-specific patterning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01027	P	occurs_in:(UBERON:0002479)	Seeded From UniProt	complete
involved_in	GO:0150062	complement-mediated synapse pruning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01027	P	part_of:(GO:0150064) part_of:(GO:0016322) occurs_in:(UBERON:0002479)	Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01027	P	part_of:(GO:0150064) occurs_in:(UBERON:0002479)	Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01027	P	has_input:(GO:0106003) has_input:(UniProtKB:P05067:PRO_0000000092) occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01027	P	has_input:(GO:0106003) occurs_in:(CL:0000129) has_input:(ComplexPortal:CPX-1134)	Seeded From UniProt	complete
involved_in	GO:0060100	positive regulation of phagocytosis, engulfment	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01027	P	has_regulation_target:(GO:0106003) occurs_in:(CL:0000129) part_of:(GO:0097242) has_regulation_target:(ComplexPortal:CPX-1134)	Seeded From UniProt	complete
	GO:0018103	protein C-linked glycosylation	PMID:25651845^[1]	ECO:0000314			P		a vitamin K-dependent plasma glycoprotein, which upon activation by thrombin in complex with thrombomodulin, regulates the coagulation cascade through a feedback loop inhibition mechanism	complete CACAO 10580
part_of	GO:0005615	extracellular space	PMID:25645918^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0007311)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[3]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000427	positive regulation of apoptotic cell clearance	PMID:19302245^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006956	complement activation	PMID:19302245^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0072562	blood microparticle	PMID:22516433^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16502470^[6]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001914)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23580065^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
involved_in	GO:0010575	positive regulation of vascular endothelial growth factor production	PMID:16452172^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:21362503^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0002367)	Seeded From UniProt	complete
involved_in	GO:0045745	positive regulation of G protein-coupled receptor signaling pathway	PMID:15833747^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031715	C5L2 anaphylatoxin chemotactic receptor binding	PMID:15833747^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010884	positive regulation of lipid storage	PMID:9555951^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010866	regulation of triglyceride biosynthetic process	PMID:10432298^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010828	positive regulation of glucose transmembrane transport	PMID:15833747^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010828	positive regulation of glucose transmembrane transport	PMID:9059512^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	PMID:15833747^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010951	negative regulation of endopeptidase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004866	P		Seeded From UniProt	complete
involved_in	GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0150064	vertebrate eye-specific patterning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0150062	complement-mediated synapse pruning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0097278	complement-dependent cytotoxicity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0060100	positive regulation of phagocytosis, engulfment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0048260	positive regulation of receptor-mediated endocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	C		Seeded From UniProt	complete
involved_in	GO:0016322	neuron remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	C		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0006956	complement activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0001970	positive regulation of activation of membrane attack complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
involved_in	GO:0001798	positive regulation of type IIa hypersensitivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01027 ensembl:ENSMUSP00000024988	P		Seeded From UniProt	complete
enables	GO:0004866	endopeptidase inhibitor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001599 InterPro:IPR002890	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000020 InterPro:IPR001840 InterPro:IPR009048 InterPro:IPR036595	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011626	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001840	P		Seeded From UniProt	complete
involved_in	GO:0006956	complement activation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001840 InterPro:IPR035711	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	PMID:9164946^[14] Reactome:R-HSA-388396	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10085065^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:4097977^[16]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:9164946^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050776	regulation of immune response	Reactome:R-HSA-198933	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044267	cellular protein metabolic process	Reactome:R-HSA-392499	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043687	post-translational protein modification	Reactome:R-HSA-597592	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0034774	secretory granule lumen	Reactome:R-HSA-6798748	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030449	regulation of complement activation	Reactome:R-HSA-977606	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006957	complement activation, alternative pathway	Reactome:R-HSA-173736	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006956	complement activation	Reactome:R-HSA-174577	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-977615 Reactome:R-HSA-977371 Reactome:R-HSA-8853252 Reactome:R-HSA-8852874 Reactome:R-HSA-3266557	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005788	endoplasmic reticulum lumen	Reactome:R-HSA-8952289	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-981728 Reactome:R-HSA-981621 Reactome:R-HSA-981539 Reactome:R-HSA-981535 Reactome:R-HSA-977629 Reactome:R-HSA-977619 Reactome:R-HSA-977615 Reactome:R-HSA-977605 Reactome:R-HSA-977602 Reactome:R-HSA-977375 Reactome:R-HSA-977371 Reactome:R-HSA-977363 Reactome:R-HSA-977359 Reactome:R-HSA-976810 Reactome:R-HSA-976768 Reactome:R-HSA-976743 Reactome:R-HSA-8852809 Reactome:R-HSA-8851436 Reactome:R-HSA-749456 Reactome:R-HSA-749454 Reactome:R-HSA-6798751 Reactome:R-HSA-6798748 Reactome:R-HSA-444647 Reactome:R-HSA-380073 Reactome:R-HSA-3266557 Reactome:R-HSA-199518 Reactome:R-HSA-183130 Reactome:R-HSA-183126 Reactome:R-HSA-183122 Reactome:R-HSA-174551 Reactome:R-HSA-173754 Reactome:R-HSA-173745 Reactome:R-HSA-173740 Reactome:R-HSA-173739 Reactome:R-HSA-173680 Reactome:R-HSA-173636 Reactome:R-HSA-166817 Reactome:R-HSA-1006143	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006631	fatty acid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0276	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0006629	lipid metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0443	P		Seeded From UniProt	complete
involved_in	GO:0006958	complement activation, classical pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0180	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0006957	complement activation, alternative pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0179	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ding, Q et al. (2015) Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays. Blood 125 2428-34 PubMed GONUTS page
↑ Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ ^4.0 ^4.1 Gullstrand, B et al. (2009) Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells. Clin. Exp. Immunol. 156 303-11 PubMed GONUTS page
↑ Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page
↑ Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page
↑ Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
↑ Nozaki, M et al. (2006) Drusen complement components C3a and C5a promote choroidal neovascularization. Proc. Natl. Acad. Sci. U.S.A. 103 2328-33 PubMed GONUTS page
↑ Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Kalant, D et al. (2005) C5L2 is a functional receptor for acylation-stimulating protein. J. Biol. Chem. 280 23936-44 PubMed GONUTS page
↑ Saleh, J et al. (1998) Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period. J. Lipid Res. 39 884-91 PubMed GONUTS page
↑ Murray, I et al. (1999) Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity. Biochem. J. 342 ( Pt 1) 41-8 PubMed GONUTS page
↑ Tao, Y et al. (1997) Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line. Biochim. Biophys. Acta 1344 221-9 PubMed GONUTS page
↑ ^14.0 ^14.1 Tornetta, MA et al. (1997) The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression. J. Immunol. 158 5277-82 PubMed GONUTS page
↑ Crass, T et al. (1999) Chimeric receptors of the human C3a receptor and C5a receptor (CD88). J. Biol. Chem. 274 8367-70 PubMed GONUTS page
↑ Alper, CA et al. (1970) Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection. J. Clin. Invest. 49 1975-85 PubMed GONUTS page

[PMID:25651845-1] Ding, Q et al. (2015) Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays. Blood 125 2428-34 PubMed GONUTS page

[PMID:25645918-2] Thaysen-Andersen, M et al. (2015) Human neutrophils secrete bioactive paucimannosidic proteins from azurophilic granules into pathogen-infected sputum. J. Biol. Chem. 290 8789-802 PubMed GONUTS page

[PMID:23533145-3] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:19302245-4] 4.0 ^4.1 Gullstrand, B et al. (2009) Complement classical pathway components are all important in clearance of apoptotic and secondary necrotic cells. Clin. Exp. Immunol. 156 303-11 PubMed GONUTS page

[PMID:22516433-5] Bastos-Amador, P et al. (2012) Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. J Proteomics 75 3574-84 PubMed GONUTS page

[PMID:16502470-6] Palmer, DJ et al. (2006) Human colostrum: identification of minor proteins in the aqueous phase by proteomics. Proteomics 6 2208-16 PubMed GONUTS page

[PMID:23580065-7] Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page

[PMID:16452172-8] Nozaki, M et al. (2006) Drusen complement components C3a and C5a promote choroidal neovascularization. Proc. Natl. Acad. Sci. U.S.A. 103 2328-33 PubMed GONUTS page

[PMID:21362503-9] Stamer, WD et al. (2011) Protein profile of exosomes from trabecular meshwork cells. J Proteomics 74 796-804 PubMed GONUTS page

[PMID:15833747-10] 10.0 ^10.1 ^10.2 ^10.3 Kalant, D et al. (2005) C5L2 is a functional receptor for acylation-stimulating protein. J. Biol. Chem. 280 23936-44 PubMed GONUTS page

[PMID:9555951-11] Saleh, J et al. (1998) Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period. J. Lipid Res. 39 884-91 PubMed GONUTS page

[PMID:10432298-12] Murray, I et al. (1999) Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity. Biochem. J. 342 ( Pt 1) 41-8 PubMed GONUTS page

[PMID:9059512-13] Tao, Y et al. (1997) Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line. Biochim. Biophys. Acta 1344 221-9 PubMed GONUTS page

[PMID:9164946-14] 14.0 ^14.1 Tornetta, MA et al. (1997) The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression. J. Immunol. 158 5277-82 PubMed GONUTS page

[PMID:10085065-15] Crass, T et al. (1999) Chimeric receptors of the human C3a receptor and C5a receptor (CD88). J. Biol. Chem. 274 8367-70 PubMed GONUTS page

[PMID:4097977-16] Alper, CA et al. (1970) Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection. J. Clin. Invest. 49 1975-85 PubMed GONUTS page

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HUMAN:CO3

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