Category:GO:0000155 ! phosphorelay sensor kinase activity

name: phosphorelay sensor kinase activity
namespace: molecular_function
def: "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:31386843, PMID:9191038]
synonym: "two-component sensor activity" NARROW []
synonym: "two-component sensor molecule" NARROW []
synonym: "two-component system sensor activity" NARROW []
is_a: GO:0004673 ! protein histidine kinase activity
is_a: GO:0140299 ! molecular sensor activity
relationship: part_of: GO:0000160 ! phosphorelay signal transduction system

AmiGO <GOterm>GO:0000155</GOterm>
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