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STRPY:D4QE70

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Species (Taxon ID) Streptococcus pyogenes. (1314)
Gene Name(s) csrS (ECO:0000313 with EMBL:BAJ05392.1) (synonyms: covS (ECO:0000313 with EMBL:AKP80838.1))
Protein Name(s) CovS (ECO:0000313 with EMBL:AKP80838.1)

CsrS (ECO:0000313 with EMBL:BAJ05392.1) CsrS/CovS (ECO:0000313 with EMBL:AFO38406.1)

External Links
UniProt D4QE70
EMBL JX006052
JX006056
JX006057
KM985481
AB525891
RefSeq WP_002985946.1
STRING 160490.SPy_0337
eggNOG ENOG4105GR3
COG0642
GO GO:0016021
GO:0005622
GO:0005524
GO:0000155
Gene3D 1.10.287.130
3.30.565.10
InterPro IPR003660
IPR003594
IPR005467
IPR003661
IPR004358
Pfam PF00672
PF02518
PF00512
PRINTS PR00344
SMART SM00304
SM00387
SM00388
SUPFAM SSF47384
SSF55874
PROSITE PS50885
PS50109

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0050765

negative regulation of phagocytosis

PMID:26945067[1]

ECO:0000315

P

In Figure 3, the experiment shows that C3b is cleaved by the F1/FH complex which inhibits opsonization that is needed to induce phagocytosis.

complete
CACAO 11706

involved_in

GO:0018106

peptidyl-histidine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004673

P

Seeded From UniProt

complete

involved_in

GO:0023014

signal transduction by protein phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0000155

P

Seeded From UniProt

complete

enables

GO:0000155

phosphorelay sensor kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003661
InterPro:IPR036097

F

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003660
InterPro:IPR003661
InterPro:IPR036097

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003660

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004358

P

Seeded From UniProt

complete

enables

GO:0016772

transferase activity, transferring phosphorus-containing groups

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR004358

F

Seeded From UniProt

complete

enables

GO:0004673

protein histidine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.13.3

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0902

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000038

ECO:0000323

imported automatically asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Agrahari, G et al. (2016) Streptococcus pyogenes employs strain-dependent mechanisms of C3b inactivation to inhibit phagocytosis and killing of bacteria. J. Biol. Chem. PubMed GONUTS page