ECOLI:NARX

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	narX (synonyms: narR)
Protein Name(s)	Nitrate/nitrite sensor protein NarX
External Links
UniProt	P0AFA2
EMBL	X13360 U00096 AP009048 X15996 M24910 X65715 X69189
PIR	S26137
RefSeq	NP_415740.1 YP_489492.1
PDB	3EZH 3EZI
PDBsum	3EZH 3EZI
ProteinModelPortal	P0AFA2
SMR	P0AFA2
DIP	DIP-35785N
IntAct	P0AFA2
STRING	511145.b1222
PaxDb	P0AFA2
PRIDE	P0AFA2
EnsemblBacteria	AAC74306 BAA36090
GeneID	12934276 945788
KEGG	ecj:Y75_p1197 eco:b1222
PATRIC	32117702
EchoBASE	EB0640
EcoGene	EG10646
eggNOG	COG3850
HOGENOM	HOG000275465
InParanoid	P0AFA2
KO	K07673
OMA	IHLLQIV
OrthoDB	EOG6JX7HQ
PhylomeDB	P0AFA2
BioCyc	EcoCyc:NARX-MONOMER ECOL316407:JW1213-MONOMER
EvolutionaryTrace	P0AFA2
PRO	PR:P0AFA2
Proteomes	UP000000318 UP000000625
Genevestigator	P0AFA2
GO	GO:0016021 GO:0005886 GO:0005524 GO:0004721 GO:0000155 GO:0006974 GO:0071249 GO:0071250 GO:0016311 GO:0042128 GO:0000160 GO:0046777 GO:0023014
Gene3D	3.30.565.10
InterPro	IPR003661 IPR003660 IPR003594 IPR029095 IPR016380 IPR011712 IPR005467
Pfam	PF00672 PF02518 PF07730 PF13675
PIRSF	PIRSF003167
SMART	SM00304 SM00387 SM00388
SUPFAM	SSF55874
PROSITE	PS50885 PS50109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:1197071^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071250	cellular response to nitrite	PMID:9426129^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0071249	cellular response to nitrate	PMID:2832370^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:8473280^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:8473280^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:2657652^[5]	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15919996^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004721	phosphoprotein phosphatase activity	PMID:8473280^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0000155	phosphorelay sensor kinase activity	PMID:8473280^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004721	P	Seeded From UniProt	complete
involved_in	GO:0018106	peptidyl-histidine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004673	P	Seeded From UniProt	complete
involved_in	GO:0018106	peptidyl-histidine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004673	P	Seeded From UniProt	complete
enables	GO:0000155	phosphorelay sensor kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011712 InterPro:IPR016380	F	Seeded From UniProt	complete
involved_in	GO:0000160	phosphorelay signal transduction system	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011712 InterPro:IPR016380	P	Seeded From UniProt	complete
enables	GO:0004673	protein histidine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016380	F	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003660	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003660 InterPro:IPR011712 InterPro:IPR016380	C	Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011712	F	Seeded From UniProt	complete
enables	GO:0004673	protein histidine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.13.3	F	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
involved_in	GO:0042128	nitrate assimilation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0534	P	Seeded From UniProt	complete
involved_in	GO:0000160	phosphorelay signal transduction system	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0902	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-KW:KW-0997 UniProtKB-SubCell:SL-0037	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Gregor, A et al. (1975) [Total and ionized serum calcium levels following surgery on the thyroid gland]. Pol Tyg Lek 30 1947-52 PubMed GONUTS page
↑ Williams, SB & Stewart, V (1997) Discrimination between structurally related ligands nitrate and nitrite controls autokinase activity of the NarX transmembrane signal transducer of Escherichia coli K-12. Mol. Microbiol. 26 911-25 PubMed GONUTS page
↑ Stewart, V & Parales, J Jr (1988) Identification and expression of genes narL and narX of the nar (nitrate reductase) locus in Escherichia coli K-12. J. Bacteriol. 170 1589-97 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Walker, MS & DeMoss, JA (1993) Phosphorylation and dephosphorylation catalyzed in vitro by purified components of the nitrate sensing system, NarX and NarL. J. Biol. Chem. 268 8391-3 PubMed GONUTS page
↑ Nohno, T et al. (1989) The narX and narL genes encoding the nitrate-sensing regulators of Escherichia coli are homologous to a family of prokaryotic two-component regulatory genes. Nucleic Acids Res. 17 2947-57 PubMed GONUTS page
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

[PMID:1197071-1] Gregor, A et al. (1975) [Total and ionized serum calcium levels following surgery on the thyroid gland]. Pol Tyg Lek 30 1947-52 PubMed GONUTS page

[PMID:9426129-2] Williams, SB & Stewart, V (1997) Discrimination between structurally related ligands nitrate and nitrite controls autokinase activity of the NarX transmembrane signal transducer of Escherichia coli K-12. Mol. Microbiol. 26 911-25 PubMed GONUTS page

[PMID:2832370-3] Stewart, V & Parales, J Jr (1988) Identification and expression of genes narL and narX of the nar (nitrate reductase) locus in Escherichia coli K-12. J. Bacteriol. 170 1589-97 PubMed GONUTS page

[PMID:8473280-4] 4.0 ^4.1 ^4.2 ^4.3 Walker, MS & DeMoss, JA (1993) Phosphorylation and dephosphorylation catalyzed in vitro by purified components of the nitrate sensing system, NarX and NarL. J. Biol. Chem. 268 8391-3 PubMed GONUTS page

[PMID:2657652-5] Nohno, T et al. (1989) The narX and narL genes encoding the nitrate-sensing regulators of Escherichia coli are homologous to a family of prokaryotic two-component regulatory genes. Nucleic Acids Res. 17 2947-57 PubMed GONUTS page

[PMID:15919996-6] Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

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ECOLI:NARX

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