GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

BACSU:DESK

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Bacillus subtilis (strain 168). (224308)
Gene Name(s) desK (synonyms: yocF)
Protein Name(s) Sensor histidine kinase DesK
External Links
UniProt O34757
EMBL AF027868
AL009126
PIR C69901
RefSeq NP_389800.1
WP_003231271.1
PDB 3EHF
3EHG
3EHH
3EHJ
3GIE
3GIF
3GIG
PDBsum 3EHF
3EHG
3EHH
3EHJ
3GIE
3GIF
3GIG
ProteinModelPortal O34757
SMR O34757
DIP DIP-48966N
STRING 224308.BSU19190
PaxDb O34757
DNASU 939678
EnsemblBacteria CAB13811
GeneID 939678
KEGG bsu:BSU19190
PATRIC 18975687
GenoList BSU19190
eggNOG COG4585
HOGENOM HOG000019645
InParanoid O34757
KO K07778
OMA HAHEVRI
OrthoDB EOG6W9X4M
PhylomeDB O34757
BioCyc BSUB:BSU19190-MONOMER
EvolutionaryTrace O34757
Proteomes UP000001570
GO GO:0016021
GO:0005886
GO:0005524
GO:0004721
GO:0000155
GO:0016311
Gene3D 3.30.565.10
InterPro IPR003594
IPR011712
Pfam PF02518
PF07730
SMART SM00387
SUPFAM SSF55874

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0004721

phosphoprotein phosphatase activity

PMID:15090506[1]

ECO:0000314

F

Fig. 3 A shows DesKC phosphatase activity

complete
CACAO 2097

GO:0004672

protein kinase activity

PMID:19805278[2]

ECO:0000314

F

Fig. 4A The left image shows kinase activity at time intervals at both 25C (top) and 37C (bottom). Kinase activity was up-regulated at lower temperature

complete
CACAO 11195

enables

GO:0004721

phosphoprotein phosphatase activity

PMID:15090506[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:19805278[2]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O34757

F

Seeded From UniProt

complete

involved_in

GO:0006470

protein dephosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004721

P

Seeded From UniProt

complete

GO:0004721

phosphoprotein phosphatase activity

PMID:19805278[2]

ECO:0000314

F

Fig. 4B Left figure show phosphatase activity of desK at 25C (top) and 37C (bottom).

complete
CACAO 11196

involved_in

GO:0018106

peptidyl-histidine phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004673

P

Seeded From UniProt

complete

GO:0016740

transferase activity

PMID:19805278[2]

ECO:0000314

F

Fig. 4C Figure on the left show phosphotransferase activity of desK at 25C (top) and 37C (bottom).

complete
CACAO 11197

involved_in

GO:0023014

signal transduction by protein phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0000155

P

Seeded From UniProt

complete

enables

GO:0000155

phosphorelay sensor kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011712

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011712

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011712

C

Seeded From UniProt

complete

enables

GO:0046983

protein dimerization activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011712

F

Seeded From UniProt

complete

enables

GO:0004673

protein histidine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.13.3

F

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0902

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Albanesi, D et al. (2004) The membrane fluidity sensor DesK of Bacillus subtilis controls the signal decay of its cognate response regulator. J. Bacteriol. 186 2655-63 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Albanesi, D et al. (2009) Structural plasticity and catalysis regulation of a thermosensor histidine kinase. Proc. Natl. Acad. Sci. U.S.A. 106 16185-90 PubMed GONUTS page