ECOLI:RCSC

Species (Taxon ID)	Escherichia coli (strain K12). (83333)
Gene Name(s)	rcsC (ECO:0000255 with HAMAP-Rule:MF_00979)
Protein Name(s)	Sensor histidine kinase RcsC (ECO:0000255 with HAMAP-Rule:MF_00979) Capsular synthesis regulator component C
External Links
UniProt	P0DMC5
EMBL	M28242 U00096 AP009048 AP009048
PIR	H64991
RefSeq	NP_416722.2
PDB	2AYX 2AYY 2AYZ
PDBsum	2AYX 2AYY 2AYZ
ProteinModelPortal	P0DMC5
SMR	P0DMC5
IntAct	P0DMC5
MINT	MINT-1267658
EnsemblBacteria	AAC75278 BAA16001 BAA16014
GeneID	948993
KEGG	eco:b2218
EchoBASE	EB0815
EcoGene	EG10822
eggNOG	COG0642
HOGENOM	HOG000122300
KO	K07677
OMA	TRCWLAV
OrthoDB	EOG6G4VQG
PhylomeDB	P0DMC5
BRENDA	2.7.13.3
Proteomes	UP000000318 UP000000625
GO	GO:0016021 GO:0005886 GO:0005524 GO:0000155 GO:0071470 GO:0000160 GO:0046777 GO:0006355 GO:0023014 GO:0044010
Gene3D	1.10.287.130 3.30.565.10
HAMAP	MF_00979
InterPro	IPR011006 IPR003661 IPR003594 IPR000014 IPR004358 IPR019017 IPR005467 IPR009082 IPR001789
Pfam	PF02518 PF00512 PF09456 PF00072
PRINTS	PR00344
SMART	SM00387 SM00388 SM00091 SM00448
SUPFAM	SSF47384 SSF52172 SSF55874
PROSITE	PS51426 PS50109 PS50110

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0071470	cellular response to osmotic stress	PMID:8576059^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
	GO:0000160	two-component signal transduction system (phosphorelay)	PMID:16166540^[2]	ECO:0000314			P	Fig. 5 shows an graph representing the epistasis of rcsC to rcsF.	complete
involved_in	GO:0046777	protein autophosphorylation	PMID:11309126^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0044010	single-species biofilm formation	PMID:14651646^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:2404948^[5]	ECO:0000245	automatically integrated combinatorial evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17309111^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:15919996^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000160	phosphorelay signal transduction system	PMID:11309126^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0000155	phosphorelay sensor kinase activity	PMID:11309126^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0000155	P	Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0000155	P	Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000155	P	Seeded From UniProt	complete
enables	GO:0000155	phosphorelay sensor kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003661 InterPro:IPR030856 InterPro:IPR036097	F	Seeded From UniProt	complete
involved_in	GO:0000160	phosphorelay signal transduction system	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001789 InterPro:IPR019017 InterPro:IPR030856	P	Seeded From UniProt	complete
enables	GO:0004673	protein histidine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019017	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019017	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019017	C	Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019017	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003661 InterPro:IPR036097	P	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019017 InterPro:IPR030856	C	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004358	P	Seeded From UniProt	complete
enables	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004358	F	Seeded From UniProt	complete
involved_in	GO:0018106	peptidyl-histidine phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR019017	P	Seeded From UniProt	complete
enables	GO:0004673	protein histidine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.13.3	F	Seeded From UniProt	complete
involved_in	GO:0000160	phosphorelay signal transduction system	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000117500	P	Seeded From UniProt	complete
enables	GO:0000155	phosphorelay sensor kinase activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000117500	F	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000117500	P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000117500	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000117500	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0997 UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0037	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
involved_in	GO:0000160	phosphorelay signal transduction system	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0902	P	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Sledjeski, DD & Gottesman, S (1996) Osmotic shock induction of capsule synthesis in Escherichia coli K-12. J. Bacteriol. 178 1204-6 PubMed GONUTS page
↑ Majdalani, N et al. (2005) Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli. J. Bacteriol. 187 6770-8 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Takeda, S et al. (2001) A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC --> YojN --> RcsB signalling pathway implicated in capsular synthesis and swarming behaviour. Mol. Microbiol. 40 440-50 PubMed GONUTS page
↑ Ferrières, L & Clarke, DJ (2003) The RcsC sensor kinase is required for normal biofilm formation in Escherichia coli K-12 and controls the expression of a regulon in response to growth on a solid surface. Mol. Microbiol. 50 1665-82 PubMed GONUTS page
↑ Stout, V & Gottesman, S (1990) RcsB and RcsC: a two-component regulator of capsule synthesis in Escherichia coli. J. Bacteriol. 172 659-69 PubMed GONUTS page
↑ Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page
↑ Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

[PMID:8576059-1] Sledjeski, DD & Gottesman, S (1996) Osmotic shock induction of capsule synthesis in Escherichia coli K-12. J. Bacteriol. 178 1204-6 PubMed GONUTS page

[PMID:16166540-2] Majdalani, N et al. (2005) Role of RcsF in signaling to the Rcs phosphorelay pathway in Escherichia coli. J. Bacteriol. 187 6770-8 PubMed GONUTS page

[PMID:11309126-3] 3.0 ^3.1 ^3.2 Takeda, S et al. (2001) A novel feature of the multistep phosphorelay in Escherichia coli: a revised model of the RcsC --> YojN --> RcsB signalling pathway implicated in capsular synthesis and swarming behaviour. Mol. Microbiol. 40 440-50 PubMed GONUTS page

[PMID:14651646-4] Ferrières, L & Clarke, DJ (2003) The RcsC sensor kinase is required for normal biofilm formation in Escherichia coli K-12 and controls the expression of a regulon in response to growth on a solid surface. Mol. Microbiol. 50 1665-82 PubMed GONUTS page

[PMID:2404948-5] Stout, V & Gottesman, S (1990) RcsB and RcsC: a two-component regulator of capsule synthesis in Escherichia coli. J. Bacteriol. 172 659-69 PubMed GONUTS page

[PMID:17309111-6] Zhang, N et al. (2007) Comparison of SDS- and methanol-assisted protein solubilization and digestion methods for Escherichia coli membrane proteome analysis by 2-D LC-MS/MS. Proteomics 7 484-93 PubMed GONUTS page

[PMID:15919996-7] Daley, DO et al. (2005) Global topology analysis of the Escherichia coli inner membrane proteome. Science 308 1321-3 PubMed GONUTS page

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ECOLI:RCSC

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