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BACSU:KINA
Contents
| Species (Taxon ID) | Bacillus subtilis (strain 168). (224308) | |
| Gene Name(s) | kinA (synonyms: gsiC, scoD, spoIIF, spoIIJ) | |
| Protein Name(s) | Sporulation kinase A
Stage II sporulation protein F Stage II sporulation protein J | |
| External Links | ||
| UniProt | P16497 | |
| EMBL | M29450 M31067 AJ222587 AL009126 | |
| PIR | A33496 | |
| RefSeq | NP_389282.1 WP_003245779.1 | |
| PDB | 2VLG | |
| PDBsum | 2VLG | |
| ProteinModelPortal | P16497 | |
| SMR | P16497 | |
| DIP | DIP-58966N | |
| IntAct | P16497 | |
| STRING | 224308.BSU13990 | |
| ChEMBL | CHEMBL2111331 | |
| PaxDb | P16497 | |
| EnsemblBacteria | CAB13272 | |
| GeneID | 939230 | |
| KEGG | bsu:BSU13990 | |
| PATRIC | 18974581 | |
| GenoList | BSU13990 | |
| eggNOG | COG0642 | |
| HOGENOM | HOG000008904 | |
| InParanoid | P16497 | |
| KO | K02491 | |
| OMA | LMVTFNI | |
| OrthoDB | EOG69GZGV | |
| PhylomeDB | P16497 | |
| BioCyc | BSUB:BSU13990-MONOMER | |
| BRENDA | 2.7.13.3 | |
| EvolutionaryTrace | P16497 | |
| Proteomes | UP000001570 | |
| GO | GO:0016020 GO:0005524 GO:0042802 GO:0000155 GO:0043938 GO:0006355 GO:0030435 | |
| Gene3D | 1.10.287.130 3.30.565.10 | |
| InterPro | IPR003661 IPR003594 IPR001610 IPR000014 IPR013767 IPR004358 IPR005467 IPR009082 | |
| Pfam | PF02518 PF00512 PF00989 | |
| PRINTS | PR00344 | |
| SMART | SM00387 SM00388 SM00086 SM00091 | |
| SUPFAM | SSF47384 SSF55785 SSF55874 | |
| TIGRFAMs | TIGR00229 | |
| PROSITE | PS50109 PS50112 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0030435 |
sporulation resulting in formation of a cellular spore |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
| GO:0043938 |
positive regulation of sporulation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
UniProtKB:P16449 UniProtKB:P39764
|
P |
Figure 2 shows kinase mutation effects on abrB expression, abrB is a negative regulator of sporulation |
complete | |||
| GO:0030435 |
sporulation resulting in formation of a cellular spore |
ECO:0000315 |
P |
Figure 4 shows KinA synthesis triggers sporulation early in the exponential phase of growth. |
complete | |||||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
| GO:0016301 |
kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Figure 1 shows that inducing the synthesis of KinA during growth triggers efficient sporulation. |
complete | ||||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0018106 |
peptidyl-histidine phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0004673 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0023014 |
signal transduction by protein phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0000155 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000155 |
phosphorelay sensor kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016772 |
transferase activity, transferring phosphorus-containing groups |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004673 |
protein histidine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0000160 |
phosphorelay signal transduction system |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030435 |
sporulation resulting in formation of a cellular spore |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 Fujita, M & Losick, R (2005) Evidence that entry into sporulation in Bacillus subtilis is governed by a gradual increase in the level and activity of the master regulator Spo0A. Genes Dev. 19 2236-44 PubMed GONUTS page
- ↑ Shafikhani, SH & Leighton, T (2004) AbrB and Spo0E control the proper timing of sporulation in Bacillus subtilis. Curr. Microbiol. 48 262-9 PubMed GONUTS page
- ↑ Dago, AE et al. (2012) Structural basis of histidine kinase autophosphorylation deduced by integrating genomics, molecular dynamics, and mutagenesis. Proc. Natl. Acad. Sci. U.S.A. 109 E1733-42 PubMed GONUTS page
- ↑ Eswaramoorthy, P et al. (2009) In vivo domain-based functional analysis of the major sporulation sensor kinase, KinA, in Bacillus subtilis. J. Bacteriol. 191 5358-68 PubMed GONUTS page
- ↑ Cunningham, KA & Burkholder, WF (2009) The histidine kinase inhibitor Sda binds near the site of autophosphorylation and may sterically hinder autophosphorylation and phosphotransfer to Spo0F. Mol. Microbiol. 71 659-77 PubMed GONUTS page
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