ENTFC:VANS

Species (Taxon ID)	Enterococcus faecium (Streptococcus faecium). (1352)
Gene Name(s)	vanS
Protein Name(s)	Sensor protein VanS Vancomycin histidine protein kinase Vancomycin resistance protein VanS
External Links
UniProt	Q06240
EMBL	M97297 M68910
PIR	B41838
RefSeq	WP_002305818.1 YP_001019037.1 YP_001974798.1 YP_002128397.1 YP_004172618.1 YP_009086371.1 YP_009088541.1 YP_009090100.1 YP_976079.1
ProteinModelPortal	Q06240
GeneID	10164672 4670246 4783149 6385883 6779648
KEGG	pg:10164672 pg:4670246 pg:4783149 pg:6385883 pg:6779648
KO	K18350
BRENDA	2.7.13.3
GO	GO:0016021 GO:0005622 GO:0005886 GO:0005524 GO:0000155 GO:0071555 GO:0046677
Gene3D	1.10.287.130 3.30.565.10
InterPro	IPR003594 IPR005467 IPR003661 IPR004358
Pfam	PF02518 PF00512
PRINTS	PR00344
SMART	SM00387 SM00388
SUPFAM	SSF47384 SSF55874
PROSITE	PS50109

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	PMID:8981985	ECO:0000316		UniProtKB:Q06239	P		Figure 4 shows that VanR by itself expresses the operon constitutively, and the authors conclude that VanS works by inhibiting VanR in the absence of inducer	complete CACAO 11269
involved_in	GO:0018106	peptidyl-histidine phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004673	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0000155	P		Seeded From UniProt	complete
enables	GO:0000155	phosphorelay sensor kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003661 InterPro:IPR036097	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003661 InterPro:IPR036097	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004358	P		Seeded From UniProt	complete
enables	GO:0016772	transferase activity, transferring phosphorus-containing groups	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004358	F		Seeded From UniProt	complete
enables	GO:0004673	protein histidine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.13.3	F		Seeded From UniProt	complete
involved_in	GO:0000160	phosphorelay signal transduction system	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0902	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0071555	cell wall organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0961	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0046	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
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