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YEAST:SSK1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) SSK1
Protein Name(s) Osmolarity two-component system protein SSK1
External Links
UniProt Q07084
EMBL L26523
Z73178
BK006945
PIR S64828
RefSeq NP_013106.1
ProteinModelPortal Q07084
SMR Q07084
BioGrid 31279
DIP DIP-2437N
IntAct Q07084
MINT MINT-506250
STRING 4932.YLR006C
MaxQB Q07084
PaxDb Q07084
PeptideAtlas Q07084
EnsemblFungi [example_ID YLR006C]
GeneID 850692
KEGG sce:YLR006C
CYGD YLR006c
SGD S000003996
eggNOG COG0784
HOGENOM HOG000001106
InParanoid Q07084
KO K11233
OMA LHLIFMD
OrthoDB EOG7GBG5H
BioCyc YEAST:G3O-32167-MONOMER
NextBio 966713
Proteomes UP000002311
Genevestigator Q07084
GO GO:0005737
GO:0031435
GO:0000156
GO:0042803
GO:0030295
GO:0000167
GO:0007234
GO:2000251
GO:0031954
InterPro IPR011006
IPR001789
Pfam PF00072
SMART SM00448
SUPFAM SSF52172
PROSITE PS50110

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:2000251

positive regulation of actin cytoskeleton reorganization

PMID:19633059[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0071468)

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:18573873[2]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0031954

positive regulation of protein autophosphorylation

PMID:9482735[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0031435

mitogen-activated protein kinase kinase kinase binding

PMID:9482735[3]

ECO:0000353

physical interaction evidence used in manual assertion

SGD:S000005314

F

Seeded From UniProt

complete

enables

GO:0030295

protein kinase activator activity

PMID:9482735[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0030295

protein kinase activator activity

PMID:9482735[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0007234

osmosensory signaling via phosphorelay pathway

PMID:8808622[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14665464[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000185

activation of MAPKKK activity

PMID:9482735[3]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000005314

P

part_of:(GO:0071474)

Seeded From UniProt

complete

involved_in

GO:0000185

activation of MAPKKK activity

PMID:18573873[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0000156

phosphorelay response regulator activity

PMID:8183345[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0000185

activation of MAPKKK activity

PMID:9482735[3]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(UniProtKB:P53599)

Seeded From UniProt

complete

part_of

GO:1990315

Mcs4 RR-MAPKKK complex

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001238280
PomBase:SPBC887.10

C

Seeded From UniProt

complete

enables

GO:0030295

protein kinase activator activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002450928
SGD:S000003996

F

Seeded From UniProt

complete

involved_in

GO:0007234

osmosensory signaling via phosphorelay pathway

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002450928
SGD:S000003996
UniProtKB:Q5AVI3

P

Seeded From UniProt

complete

enables

GO:0000156

phosphorelay response regulator activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN002450928
PomBase:SPBC887.10
SGD:S000003996

F

Seeded From UniProt

complete

enables

GO:0000155

phosphorelay sensor kinase activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

EcoGene:EG13461
PANTHER:PTN002450928

F

Seeded From UniProt

complete

involved_in

GO:0023014

signal transduction by protein phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0000155

P

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001789

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0000160

phosphorelay signal transduction system

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0902

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Motizuki, M & Xu, Z (2009) Importance of polarisome proteins in reorganization of actin cytoskeleton at low pH in Saccharomyces cerevisiae. J. Biochem. 146 705-12 PubMed GONUTS page
  2. 2.0 2.1 Horie, T et al. (2008) Phosphorylated Ssk1 prevents unphosphorylated Ssk1 from activating the Ssk2 mitogen-activated protein kinase kinase kinase in the yeast high-osmolarity glycerol osmoregulatory pathway. Mol. Cell. Biol. 28 5172-83 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Posas, F & Saito, H (1998) Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator. EMBO J. 17 1385-94 PubMed GONUTS page
  4. Posas, F et al. (1996) Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor. Cell 86 865-75 PubMed GONUTS page
  5. Lu, JM et al. (2003) Saccharomyces cerevisiae histidine phosphotransferase Ypd1p shuttles between the nucleus and cytoplasm for SLN1-dependent phosphorylation of Ssk1p and Skn7p. Eukaryotic Cell 2 1304-14 PubMed GONUTS page
  6. Maeda, T et al. (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 369 242-5 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page