User:Finchcha

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
updatedbyinstructor	MOUSE:PITX1	2013-03-30 23:33:13 CDT	GO:0045892 negative regulation of transcription, DNA-dependent (P)	PMID:21300782	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 3 shows that TERT expression levels are decreased when PITX1 expression is high. Figure 4 further details that TERT expression is controlled through PITX1 binding to the promoter region of TERT.	challenge
requireschanges	PSEAE:Q9HTL4	2013-04-10 19:56:40 CDT	GO:0001071 nucleic acid binding transcription factor activity (F)	PMID:22275523	ECO:0000314 direct assay evidence used in manual assertion	EMSA results in figure 2 prove OxyR binds to the promoter regions of several P. aerugenosa genes. Additionally, figure 3 shows that expression of dps, pvdS and trxB2 genes increased in the presence of OxyR activated by H2O2.	challenge
updatedbyinstructor	CAMJU:B5LWZ9	2013-04-11 11:38:27 CDT	GO:0006355 regulation of transcription, DNA-dependent (P)	PMID:19502436	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2 compares expression of ars operon genes in arsR deletion mutants with wild-type. Expression of ars operon genes is significantly increased in the deletion mutant proving the arsR gene acts as an ars operon repressor.	challenge
updatedbyinstructor	EMEND:E7EDM2	2013-04-14 15:38:32 CDT	GO:0072659 protein localization to plasma membrane (P)	PMID:22489878	ECO:0000315 mutant phenotype evidence used in manual assertion	"These phenotypes correlate with miss-routing of the YAT plasma membrane transporters AgtA (glutamate) and PrnB (proline) to the vacuole under conditions that, in the wild type, result in their delivery to the plasma membrane. "	challenge
acceptable	EMEND:Q8TFN9	2013-04-14 16:47:14 CDT	GO:0015200 methylammonium transmembrane transporter activity (F)	PMID:12455974	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4C shows that meaA deletion mutants take up less methylammonium at 1mM final methylammonium concentration than wildtype A. nidulans suggesting meaA functions as an ammonium transporter.	challenge
acceptable	EMEND:Q8TFN8	2013-04-14 16:51:49 CDT	GO:0015200 methylammonium transmembrane transporter activity (F)	PMID:12455974	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4C shows that mepA deletion mutants take up methylammonium at a lower rate than wildtype A. nidulans cells suggesting mepA's role as an ammonium transporter.	challenge
updatedbyinstructor	EMEND:Q00171	2013-04-14 17:37:15 CDT	GO:0045893 positive regulation of transcription, DNA-dependent (P)	PMID:16467464	ECO:0000315 mutant phenotype evidence used in manual assertion	Multiplex RT-PCR results in figure 6B shows that AreA deletion mutants transcribe less methylammonium transporter genes than wild-type suggesting that areA acts as a transcriptional activator for meaA and mepA.	challenge
updatedbyinstructor	EMEND:Q400D8	2013-04-14 17:56:26 CDT	GO:0015758 glucose transport (P)	PMID:16418173	ECO:0000315 mutant phenotype evidence used in manual assertion	Fig 8.	challenge

acceptable:2
unacceptable:0
requires_changes:1
flagged:0

Annotations challenged by Finchcha

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Emily.krummel, Team Endoplasmic Reticulum	STRCO:Q9KYY6	GO:0017000 - antibiotic biosynthetic process (P)	PMID:23232715	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1
updatedbyinstructor	Mill2034, Team Its Miller Time	ECOLI:CPXR	GO:0045893 - positive regulation of DNA-templated transcription (P)	PMID:15743952	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
requireschanges	Mill2034, Team Its Miller Time	?	GO:0010629 - negative regulation of gene expression (Figure 8 shows that when a mutant for the gene is made, there is an increase in expression of the gene regulated by HDA6)	PMID:22102827	IMP: Inferred from Mutant Phenotype	challenge	C: 3
acceptable	Raoneha, Team Peacock	DROME:CHD1	GO:0140658 - ATP-dependent chromatin remodeler activity (F)	PMID:23533627	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 1
updatedbyinstructor	Andrew.james, Team Gene Wilder	DROME:Q9Y1L3	GO:0140658 - ATP-dependent chromatin remodeler activity (F)	PMID:18250149	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 4
updatedbyinstructor	Alemus, Team Blot Blot Western Baby	HPV18:VE2	GO:0044163 - host cytoskeleton (C)	PMID:15020762	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 7

0 annotations fixed by Finchcha

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