GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
|Status||Page||User||Date/Time||GO Term (Aspect)||Reference||Evidence||Notes||Links|
|HUMAN:P53||Raoneha, Team Peacock||2013-04-14 15:33:11 CDT||GO:0030330 DNA damage response, signal transduction by p53 class mediator (P)||PMID:22955915||ECO:0000315 mutant phenotype evidence used in manual assertion|
Figure 1 shows that a mutation in the p53 results in mutations in the DNA-binding domain, in DLBCL (Diffuse large B-cell lymphoma) patients
Figure 2 shows that a mutation of the p53 results in poor survival rates for those with DLBCL
|HUMAN:DCR1A||Neillmeg, Team Peacock||2013-04-10 12:28:00 CDT||GO:0035312 5'-3' exodeoxyribonuclease activity (F)||PMID:22692201||ECO:0000314 direct assay evidence used in manual assertion|
|MOUSE:UBP44||Neillmeg, Team Peacock||2013-04-08 16:06:31 CDT||GO:0007059 chromosome segregation (P)||PMID:23187126||ECO:0000315 mutant phenotype evidence used in manual assertion|
see figures 1 and 2 to see how the protein is the one to help with chromosome segregation
|AZOL4:G7ZFL4||Neillmeg, Team Peacock||2013-04-08 16:04:37 CDT||GO:0002534 cytokine production involved in inflammatory response (P)||PMID:23202729||ECO:0000314 direct assay evidence used in manual assertion|
see figure 2 for the results of the direct assay and the proof that the protein produces cytokine that is involved in inflammatory responce
|HUMAN:HDAC6||Neillmeg, Team Peacock||2013-04-08 15:55:39 CDT||GO:0004407 histone deacetylase activity (F)||PMID:23322205||ECO:0000315 mutant phenotype evidence used in manual assertion|
see figure 2 to experimental results that show the proteins ablity to deacetylase activity
|HUMAN:Q05CP8||Neillmeg, Team Peacock||2013-04-08 15:52:55 CDT||GO:0007090 regulation of S phase of mitotic cell cycle (P)||PMID:22363533||ECO:0000315 mutant phenotype evidence used in manual assertion|
see Figure 2 in paper to see the experiment done to show that the protein is used to regulate the S phase of mitotic cell cycle
|HUMAN:DCR1B||Neillmeg, Team Peacock||2013-04-08 15:42:45 CDT||GO:0008409 5'-3' exonuclease activity (F)||PMID:22692201||ECO:0000314 direct assay evidence used in manual assertion|
Figure 1 shows the experiment to show the exonuclease activity
|DROME:CHD1||Raoneha, Team Peacock||2013-03-28 14:03:56 CDT||GO:0140658 ATP-dependent chromatin remodeler activity (F)||PMID:23533627||ECO:0000315 mutant phenotype evidence used in manual assertion|
Figure 1A indicates that a loss of CHD1 results in defective polytene chromosomes. Figure 3 shows that a lack in CHD1 can led to increased levels of HP1a and the H3K9me2 repressive chromatin. Fig 4 shows that an increase in CHD1 leads to disruption in chromosome structure, whereas a decrease of the ATP inactivated form of CHD1 didn't have much affect.
GO term changed per Ticket-3833 ~~~~
|HUMAN:SMUF1||Neillmeg, Team Peacock||2013-03-28 12:12:04 CDT||GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (P)||PMID:21454619||ECO:0000315 mutant phenotype evidence used in manual assertion|
Figure 4 shows how the mutation of this gene affects the regulation of the WFS1 protien
|CATRO:E3UTU0||Neillmeg, Team Peacock||2013-03-26 11:54:51 CDT||GO:0008170 N-methyltransferase activity (F)||PMID:20956330||ECO:0000314 direct assay evidence used in manual assertion|
Figure 3 and the paragraph explaining the results of the essay explain how the protein has N-methyltransferase activity.