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MOUSE:UBP44
Contents
| Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
| Gene Name(s) | Usp44 | |
| Protein Name(s) | Ubiquitin carboxyl-terminal hydrolase 44
Deubiquitinating enzyme 44 Ubiquitin thioesterase 44 Ubiquitin-specific-processing protease 44 | |
| External Links | ||
| UniProt | Q8C2S0 | |
| EMBL | AK088109 CJ236846 AC124686 BC111886 | |
| RefSeq | NP_001193780.1 | |
| UniGene | Mm.491598 | |
| ProteinModelPortal | Q8C2S0 | |
| SMR | Q8C2S0 | |
| BioGrid | 236490 | |
| STRING | 10090.ENSMUSP00000092975 | |
| MEROPS | C19.057 | |
| PhosphoSite | Q8C2S0 | |
| PRIDE | Q8C2S0 | |
| GeneID | 327799 | |
| KEGG | mmu:327799 | |
| UCSC | uc011xlw.1 | |
| CTD | 84101 | |
| MGI | MGI:3045318 | |
| eggNOG | KOG1867 | |
| HOGENOM | HOG000015084 | |
| HOVERGEN | HBG018027 | |
| InParanoid | Q8C2S0 | |
| KO | K11834 | |
| OrthoDB | EOG7JX33S | |
| NextBio | 397964 | |
| PRO | PR:Q8C2S0 | |
| Proteomes | UP000000589 | |
| Bgee | Q8C2S0 | |
| Genevestigator | Q8C2S0 | |
| GO | GO:0005634 GO:0008234 GO:0036459 GO:0008270 GO:0007067 GO:0043161 GO:0090266 | |
| Gene3D | 3.30.40.10 | |
| InterPro | IPR001394 IPR018200 IPR028889 IPR013083 IPR001607 | |
| Pfam | PF00443 PF02148 | |
| PROSITE | PS00972 PS00973 PS50235 PS50271 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0007059 |
chromosome segregation |
ECO:0000315 |
P |
see figures 1 and 2 to see how the protein is the one to help with chromosome segregation |
complete | |||||
|
involved_in |
GO:0007059 |
chromosome segregation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0090266 |
regulation of mitotic cell cycle spindle assembly checkpoint |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1858178 |
C |
Seeded From UniProt |
complete | ||
|
acts_upstream_of_or_within |
GO:1904667 |
negative regulation of ubiquitin protein ligase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036459 |
thiol-dependent ubiquitinyl hydrolase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0016579 |
protein deubiquitination |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004843 |
thiol-dependent ubiquitin-specific protease activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:1904667 |
negative regulation of ubiquitin protein ligase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9H0E7 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0036459 |
thiol-dependent ubiquitinyl hydrolase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9H0E7 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016579 |
protein deubiquitination |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9H0E7 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9H0E7 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004843 |
thiol-dependent ubiquitin-specific protease activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q9H0E7 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006511 |
ubiquitin-dependent protein catabolic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008270 |
zinc ion binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016579 |
protein deubiquitination |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036459 |
thiol-dependent ubiquitinyl hydrolase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0036459 |
thiol-dependent ubiquitinyl hydrolase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0007049 |
cell cycle |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051301 |
cell division |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008233 |
peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006508 |
proteolysis |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008234 |
cysteine-type peptidase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Zhang, Y et al. (2012) USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J. Clin. Invest. 122 4362-74 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 Zhang, Y et al. (2011) Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. PLoS ONE 6 e23389 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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