HUMAN:HDAC6

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	HDAC6 (synonyms: KIAA0901)
Protein Name(s)	Histone deacetylase 6 HD6
External Links
UniProt	Q9UBN7
EMBL	AF132609 AB020708 AJ011972 AF196971 CH471224 BC013737 BC069243
CCDS	CCDS14306.1
RefSeq	NP_006035.2 XP_005272622.1 XP_005272623.1 XP_005272625.1 XP_006724588.1
UniGene	Hs.6764
PDB	3C5K 3GV4 3PHD
PDBsum	3C5K 3GV4 3PHD
ProteinModelPortal	Q9UBN7
SMR	Q9UBN7
BioGrid	115330
DIP	DIP-27544N
IntAct	Q9UBN7
MINT	MINT-4905696
STRING	9606.ENSP00000334061
BindingDB	Q9UBN7
ChEMBL	CHEMBL1865
DrugBank	DB02546
GuidetoPHARMACOLOGY	2618
PhosphoSite	Q9UBN7
DMDM	205371758
MaxQB	Q9UBN7
PaxDb	Q9UBN7
PRIDE	Q9UBN7
DNASU	10013
Ensembl	ENST00000334136 ENST00000376619
GeneID	10013
KEGG	hsa:10013
UCSC	uc004dks.1
CTD	10013
GeneCards	GC0XP048659
H-InvDB	HIX0016783
HGNC	HGNC:14064
HPA	CAB004236 HPA003714 HPA026321
MIM	300272 300863
neXtProt	NX_Q9UBN7
Orphanet	163966
PharmGKB	PA29231
eggNOG	COG0123
GeneTree	ENSGT00530000062809
HOGENOM	HOG000004769
HOVERGEN	HBG051894
InParanoid	Q9UBN7
KO	K11407
PhylomeDB	Q9UBN7
TreeFam	TF106173
BRENDA	3.5.1.98
Reactome	REACT_118780 REACT_160243 REACT_160254 REACT_200744
SABIO-RK	Q9UBN7
SignaLink	Q9UBN7
ChiTaRS	HDAC6
EvolutionaryTrace	Q9UBN7
GeneWiki	HDAC6
GenomeRNAi	10013
NextBio	37827
PRO	PR:Q9UBN7
Proteomes	UP000005640
Bgee	Q9UBN7
CleanEx	HS_HDAC6
ExpressionAtlas	Q9UBN7
Genevestigator	Q9UBN7
GO	GO:0016235 GO:0030424 GO:0005901 GO:0031252 GO:0005737 GO:0005881 GO:0005829 GO:0030425 GO:0000118 GO:0016234 GO:0005874 GO:0005875 GO:0005634 GO:0043204 GO:0048471 GO:0043014 GO:0008013 GO:0001047 GO:0070840 GO:0019899 GO:0004407 GO:0042826 GO:0051879 GO:0008017 GO:0032041 GO:0097372 GO:0046969 GO:0046970 GO:0031593 GO:0048156 GO:0042903 GO:0031625 GO:0008270 GO:0070842 GO:0070301 GO:0071218 GO:0035967 GO:0016575 GO:0070846 GO:0006886 GO:0032418 GO:0016236 GO:0006515 GO:0010727 GO:0007026 GO:0051354 GO:0043242 GO:0045861 GO:0045892 GO:0034983 GO:0070845 GO:0090035 GO:0010634 GO:1901300 GO:0010870 GO:0009967 GO:0043241 GO:0006476 GO:0000209 GO:0060765 GO:0070201 GO:0040029 GO:0060632 GO:0010469 GO:0070848 GO:0051788 GO:0010033 GO:0009636 GO:0006351 GO:0090042 GO:0043162
Gene3D	3.30.40.10 3.40.800.20
InterPro	IPR000286 IPR023801 IPR013083 IPR001607
PANTHER	PTHR10625
Pfam	PF00850 PF02148
PRINTS	PR01270
SMART	SM00290
PROSITE	PS50271

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004407	histone deacetylase activity	PMID:23322205^[1]	ECO:0000315			F		see figure 2 to experimental results that show the proteins ablity to deacetylase activity	complete CACAO 7389
enables	GO:0048156	tau protein binding	PMID:19457097^[2]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2V5	F	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
NOT\|involved_in	GO:0106047	polyamine deacetylation	PMID:28516954^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|involved_in	GO:0106048	spermidine deacetylation	PMID:28516954^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
NOT\|enables	GO:0047611	acetylspermidine deacetylase activity	PMID:28516954^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	PMID:28516954^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:28516954^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032461	positive regulation of protein oligomerization	PMID:23962722^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P10636-6)	Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	PMID:23962722^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P10636-6) positively_regulates:(GO:0051259) positively_regulates:(GO:0018105)	Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	PMID:19457097^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:28386764^[5]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:23962722^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10636) positively_regulates:(GO:0051259)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24687993^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0061734	parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization	PMID:20457763^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9JK66,UniProtKB:Q9Z2V5	P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:23580651^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P00441)	Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:23322205^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:21753002^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:24413532^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0040029	regulation of gene expression, epigenetic	PMID:24413532^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death	PMID:18606987^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090042	tubulin deacetylation	PMID:19228685^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090035	positive regulation of chaperone-mediated protein complex assembly	PMID:19158084^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	PMID:18356165^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070846	Hsp90 deacetylation	PMID:19158084^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070845	polyubiquitinated misfolded protein transport	PMID:14675537^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070842	aggresome assembly	PMID:14675537^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0070840	dynein complex binding	PMID:14675537^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070301	cellular response to hydrogen peroxide	PMID:18606987^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060632	regulation of microtubule-based movement	PMID:19228685^[12]	ECO:0000305	curator inference used in manual assertion	GO:0008017	P		Seeded From UniProt	complete
enables	GO:0051879	Hsp90 protein binding	PMID:15916966^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051788	response to misfolded protein	PMID:14675537^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051354	negative regulation of oxidoreductase activity	PMID:18606987^[11]	ECO:0000305	curator inference used in manual assertion	GO:0034983	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	PMID:12024216^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:18636984^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	PMID:18356165^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043242	negative regulation of protein complex disassembly	PMID:15916966^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043014	alpha-tubulin binding	PMID:19228685^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	PMID:19228685^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035967	cellular response to topologically incorrect protein	PMID:16192271^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	PMID:18606987^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	PMID:18356165^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032418	lysosome localization	PMID:16192271^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031593	polyubiquitin modification-dependent protein binding	PMID:14675537^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031252	cell leading edge	PMID:12024216^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0030286	dynein complex	PMID:14675537^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:10220385^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	PMID:16192271^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	PMID:14675537^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016234	inclusion body	PMID:16192271^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	PMID:18316616^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	PMID:15916966^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010727	negative regulation of hydrogen peroxide metabolic process	PMID:18606987^[11]	ECO:0000305	curator inference used in manual assertion	GO:0034983	P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	PMID:12024216^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	PMID:19158084^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	PMID:19158084^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009967	positive regulation of signal transduction	PMID:19158084^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	PMID:19158084^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	PMID:19228685^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:18356165^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P35222	F		Seeded From UniProt	complete
involved_in	GO:0006886	intracellular protein transport	PMID:16192271^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	PMID:14675537^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:15916966^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:18356165^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005875	microtubule associated complex	PMID:19228685^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:10220385^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0090042	tubulin deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2V5	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11861901^[22]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969S8	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2V5	C		Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	PMID:12620231^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2V5	F		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:12620231^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8IXJ6	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2V5	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2V5	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11861901^[22]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969S8	F		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	PMID:11861901^[22]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969S8	P		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2V5	F		Seeded From UniProt	complete
part_of	GO:0005874	microtubule	PMID:12620231^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2V5	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11861901^[22]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q969S8	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z2V5	C		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:11948178^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051787	misfolded protein binding	PMID:17785525^[25]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:10220385^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0032041	P		Seeded From UniProt	complete
involved_in	GO:0098779	positive regulation of mitophagy in response to mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0090042	tubulin deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0071218	cellular response to misfolded protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0070846	Hsp90 deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0070842	aggresome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0070201	regulation of establishment of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0060997	dendritic spine morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0051646	mitochondrion localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0048668	collateral sprouting	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
enables	GO:0048487	beta-tubulin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	F		Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	F		Seeded From UniProt	complete
involved_in	GO:0045598	regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
involved_in	GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
enables	GO:0043130	ubiquitin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	F		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	F		Seeded From UniProt	complete
involved_in	GO:0034983	peptidyl-lysine deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
involved_in	GO:0032984	protein-containing complex disassembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
enables	GO:0008017	microtubule binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	F		Seeded From UniProt	complete
involved_in	GO:0007026	negative regulation of microtubule depolymerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0006511	ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
part_of	GO:0005881	cytoplasmic microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	F		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z2V5 ensembl:ENSMUSP00000033501	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001607	F		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	PMID:19457097^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	adjacent_to:(GO:0031965)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:19457097^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19457097^[2]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0042903	tubulin deacetylase activity	PMID:19457097^[2] Reactome:R-HSA-5618331	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	occurs_in:(GO:0005737) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0090042	tubulin deacetylation	PMID:28386764^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	PMID:28386764^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:1903146	regulation of autophagy of mitochondrion	PMID:25548531^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	PMID:25548531^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005771	multivesicular body	PMID:25548531^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060765	regulation of androgen receptor signaling pathway	PMID:18852123^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060271	cilium assembly	Reactome:R-HSA-5617833	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5618331 Reactome:R-HSA-5324632	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0966	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0003779	actin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0009	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0072	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0279	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0283	C		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0197	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kaliszczak, M et al. (2013) A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. Br. J. Cancer 108 342-50 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Perez, M et al. (2009) Tau--an inhibitor of deacetylase HDAC6 function. J. Neurochem. 109 1756-66 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Hai, Y et al. (2017) Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nat Commun 8 15368 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Cook, C et al. (2014) Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Hum. Mol. Genet. 23 104-16 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ Balasubramanian, A et al. (2014) Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation. FASEB J. 28 2955-69 PubMed GONUTS page
↑ Lee, JY et al. (2010) Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 189 671-9 PubMed GONUTS page
↑ Gal, J et al. (2013) HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation. J. Biol. Chem. 288 15035-45 PubMed GONUTS page
↑ Van Humbeeck, C et al. (2011) Parkin interacts with Ambra1 to induce mitophagy. J. Neurosci. 31 10249-61 PubMed GONUTS page
↑ ^10.0 ^10.1 Kang, HJ et al. (2014) Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 74 1484-94 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Parmigiani, RB et al. (2008) HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc. Natl. Acad. Sci. U.S.A. 105 9633-8 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Zhou, J et al. (2009) The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner. J. Biol. Chem. 284 9648-55 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Kekatpure, VD et al. (2009) HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. J. Biol. Chem. 284 7436-45 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Li, Y et al. (2008) HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J. Biol. Chem. 283 12686-90 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Kawaguchi, Y et al. (2003) The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115 727-38 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Kovacs, JJ et al. (2005) HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol. Cell 18 601-7 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 Hubbert, C et al. (2002) HDAC6 is a microtubule-associated deacetylase. Nature 417 455-8 PubMed GONUTS page
↑ Ding, H et al. (2008) Histone deacetylase 6 interacts with the microtubule-associated protein tau. J. Neurochem. 106 2119-30 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Iwata, A et al. (2005) HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J. Biol. Chem. 280 40282-92 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Grozinger, CM et al. (1999) Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. U.S.A. 96 4868-73 PubMed GONUTS page
↑ Biçaku, E et al. (2008) Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res. 68 1513-9 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 Tong, JJ et al. (2002) Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. 30 1114-23 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 North, BJ et al. (2003) The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell 11 437-44 PubMed GONUTS page
↑ Gao, L et al. (2002) Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. 277 25748-55 PubMed GONUTS page
↑ Boyault, C et al. (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 21 2172-81 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Lopes da Fonseca, T & Outeiro, TF (2014) ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy. Exp Neurobiol 23 314-23 PubMed GONUTS page
↑ Basak, S et al. (2008) Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function. Mol. Cancer Ther. 7 3195-202 PubMed GONUTS page

[PMID:23322205-1] 1.0 ^1.1 Kaliszczak, M et al. (2013) A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growth. Br. J. Cancer 108 342-50 PubMed GONUTS page

[PMID:19457097-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Perez, M et al. (2009) Tau--an inhibitor of deacetylase HDAC6 function. J. Neurochem. 109 1756-66 PubMed GONUTS page

[PMID:28516954-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Hai, Y et al. (2017) Histone deacetylase 10 structure and molecular function as a polyamine deacetylase. Nat Commun 8 15368 PubMed GONUTS page

[PMID:23962722-4] 4.0 ^4.1 ^4.2 Cook, C et al. (2014) Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Hum. Mol. Genet. 23 104-16 PubMed GONUTS page

[PMID:28386764-5] 5.0 ^5.1 ^5.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:24687993-6] Balasubramanian, A et al. (2014) Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation. FASEB J. 28 2955-69 PubMed GONUTS page

[PMID:20457763-7] Lee, JY et al. (2010) Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. J. Cell Biol. 189 671-9 PubMed GONUTS page

[PMID:23580651-8] Gal, J et al. (2013) HDAC6 regulates mutant SOD1 aggregation through two SMIR motifs and tubulin acetylation. J. Biol. Chem. 288 15035-45 PubMed GONUTS page

[PMID:21753002-9] Van Humbeeck, C et al. (2011) Parkin interacts with Ambra1 to induce mitophagy. J. Neurosci. 31 10249-61 PubMed GONUTS page

[PMID:24413532-10] 10.0 ^10.1 Kang, HJ et al. (2014) Differential regulation of estrogen receptor α expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 74 1484-94 PubMed GONUTS page

[PMID:18606987-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Parmigiani, RB et al. (2008) HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc. Natl. Acad. Sci. U.S.A. 105 9633-8 PubMed GONUTS page

[PMID:19228685-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Zhou, J et al. (2009) The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner. J. Biol. Chem. 284 9648-55 PubMed GONUTS page

[PMID:19158084-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Kekatpure, VD et al. (2009) HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling. J. Biol. Chem. 284 7436-45 PubMed GONUTS page

[PMID:18356165-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Li, Y et al. (2008) HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. J. Biol. Chem. 283 12686-90 PubMed GONUTS page

[PMID:14675537-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 ^15.7 Kawaguchi, Y et al. (2003) The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115 727-38 PubMed GONUTS page

[PMID:15916966-16] 16.0 ^16.1 ^16.2 ^16.3 Kovacs, JJ et al. (2005) HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. Mol. Cell 18 601-7 PubMed GONUTS page

[PMID:12024216-17] 17.0 ^17.1 ^17.2 Hubbert, C et al. (2002) HDAC6 is a microtubule-associated deacetylase. Nature 417 455-8 PubMed GONUTS page

[PMID:18636984-18] Ding, H et al. (2008) Histone deacetylase 6 interacts with the microtubule-associated protein tau. J. Neurochem. 106 2119-30 PubMed GONUTS page

[PMID:16192271-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Iwata, A et al. (2005) HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J. Biol. Chem. 280 40282-92 PubMed GONUTS page

[PMID:10220385-20] 20.0 ^20.1 ^20.2 Grozinger, CM et al. (1999) Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Natl. Acad. Sci. U.S.A. 96 4868-73 PubMed GONUTS page

[PMID:18316616-21] Biçaku, E et al. (2008) Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res. 68 1513-9 PubMed GONUTS page

[PMID:11861901-22] 22.0 ^22.1 ^22.2 ^22.3 Tong, JJ et al. (2002) Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. 30 1114-23 PubMed GONUTS page

[PMID:12620231-23] 23.0 ^23.1 ^23.2 North, BJ et al. (2003) The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol. Cell 11 437-44 PubMed GONUTS page

[PMID:11948178-24] Gao, L et al. (2002) Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. J. Biol. Chem. 277 25748-55 PubMed GONUTS page

[PMID:17785525-25] Boyault, C et al. (2007) HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 21 2172-81 PubMed GONUTS page

[PMID:25548531-26] 26.0 ^26.1 ^26.2 Lopes da Fonseca, T & Outeiro, TF (2014) ATP13A2 and Alpha-synuclein: a Metal Taste in Autophagy. Exp Neurobiol 23 314-23 PubMed GONUTS page

[PMID:18852123-27] Basak, S et al. (2008) Genistein down-regulates androgen receptor by modulating HDAC6-Hsp90 chaperone function. Mol. Cancer Ther. 7 3195-202 PubMed GONUTS page

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