HUMAN:DCR1B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	DCLRE1B (synonyms: SNM1B)
Protein Name(s)	5' exonuclease Apollo DNA cross-link repair 1B protein SNM1 homolog B SNMIB hSNM1B
External Links
UniProt	Q9H816
EMBL	AK022872 AK024060 AY849379 AL137856 BC029687
CCDS	CCDS866.1
RefSeq	NP_073747.1
UniGene	Hs.591412
PDB	3BUA 3ZDK
PDBsum	3BUA 3ZDK
ProteinModelPortal	Q9H816
SMR	Q9H816
BioGrid	122331
DIP	DIP-42669N
IntAct	Q9H816
MINT	MINT-3372972
STRING	9606.ENSP00000358576
PhosphoSite	Q9H816
DMDM	73620756
PaxDb	Q9H816
PRIDE	Q9H816
DNASU	64858
Ensembl	ENST00000369563
GeneID	64858
KEGG	hsa:64858
UCSC	uc001eeg.3
CTD	64858
GeneCards	GC01P114447
HGNC	HGNC:17641
MIM	305000 609683
neXtProt	NX_Q9H816
PharmGKB	PA27175
eggNOG	COG1236
GeneTree	ENSGT00530000063183
HOGENOM	HOG000043118
HOVERGEN	HBG081420
KO	K15341
OMA	PCQVVPI
OrthoDB	EOG71VSSC
PhylomeDB	Q9H816
TreeFam	TF329572
EvolutionaryTrace	Q9H816
GeneWiki	DCLRE1B
GenomeRNAi	64858
NextBio	67007
PRO	PR:Q9H816
Proteomes	UP000005640
Bgee	Q9H816
CleanEx	HS_DCLRE1B
Genevestigator	Q9H816
GO	GO:0005813 GO:0000781 GO:0005737 GO:0005634 GO:0008409 GO:0000075 GO:0006281 GO:0090305 GO:0031848 GO:0000723 GO:0031860 GO:0031627
Gene3D	3.60.15.10
InterPro	IPR001279 IPR011084
Pfam	PF07522
SMART	SM00849
SUPFAM	SSF56281

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0008409	5'-3' exonuclease activity	PMID:22692201^[1]	ECO:0000314			F	Figure 1 shows the experiment to show the exonuclease activity	complete CACAO 7386
involved_in	GO:0036297	interstrand cross-link repair	PMID:20479256^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010833	telomere maintenance via telomere lengthening	PMID:20479256^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031848	protection from non-homologous end joining at telomere	PMID:20479256^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:20479256^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	PMID:20479256^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0016233	telomere capping	PMID:20479256^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	PMID:18202258^[3]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-152	F	Seeded From UniProt	complete
colocalizes_with	GO:0000784	nuclear chromosome, telomeric region	PMID:24270157^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:19135898^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0008409	5'-3' exonuclease activity	PMID:22692201^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0031860	telomeric 3' overhang formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8C7W7	P	Seeded From UniProt	complete
involved_in	GO:0031848	protection from non-homologous end joining at telomere	PMID:16730175^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031627	telomeric loop formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q8C7W7	P	Seeded From UniProt	complete
enables	GO:0008409	5'-3' exonuclease activity	PMID:16730175^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008409	5'-3' exonuclease activity	PMID:20655466^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:19197158^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	PMID:16730175^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	PMID:20655466^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:20655466^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007093	mitotic cell cycle checkpoint	PMID:19197158^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0036297	interstrand cross-link repair	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000581728 PomBase:SPAC22A12.01c SGD:S000004745 UniProtKB:Q9H816	P	Seeded From UniProt	complete
enables	GO:0035312	5'-3' exodeoxyribonuclease activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000581728 UniProtKB:Q6PJP8	F	Seeded From UniProt	complete
involved_in	GO:0031848	protection from non-homologous end joining at telomere	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2156057 PANTHER:PTN000581728 UniProtKB:Q9H816	P	Seeded From UniProt	complete
involved_in	GO:0006303	double-strand break repair via nonhomologous end joining	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000581728 dictyBase:DDB_G0277755	P	Seeded From UniProt	complete
enables	GO:0003684	damaged DNA binding	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000581728 SGD:S000004745	F	Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000581728 UniProtKB:Q9H816	C	Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008409	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008409	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008409	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008409	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035312	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004527	P	Seeded From UniProt	complete
involved_in	GO:0090305	nucleic acid phosphodiester bond hydrolysis	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004518	P	Seeded From UniProt	complete
involved_in	GO:0031860	telomeric 3' overhang formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C7W7 ensembl:ENSMUSP00000029435	P	Seeded From UniProt	complete
involved_in	GO:0031848	protection from non-homologous end joining at telomere	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C7W7 ensembl:ENSMUSP00000029435	P	Seeded From UniProt	complete
involved_in	GO:0031627	telomeric loop formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C7W7 ensembl:ENSMUSP00000029435	P	Seeded From UniProt	complete
enables	GO:0008409	5'-3' exonuclease activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C7W7 ensembl:ENSMUSP00000029435	F	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C7W7 ensembl:ENSMUSP00000029435	C	Seeded From UniProt	complete
enables	GO:0004518	nuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0540	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0004527	exonuclease activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0269	F	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F	Seeded From UniProt	complete
part_of	GO:0000781	chromosome, telomeric region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0779 UniProtKB-SubCell:SL-0276	C	Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Sengerová, B et al. (2012) Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. J. Biol. Chem. 287 26254-67 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Touzot, F et al. (2010) Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome. Proc. Natl. Acad. Sci. U.S.A. 107 10097-102 PubMed GONUTS page
↑ Chen, Y et al. (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319 1092-6 PubMed GONUTS page
↑ Grolimund, L et al. (2013) A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun 4 2848 PubMed GONUTS page
↑ Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Lenain, C et al. (2006) The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr. Biol. 16 1303-10 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Ye, J et al. (2010) TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Cell 142 230-42 PubMed GONUTS page
↑ ^8.0 ^8.1 Liu, L et al. (2009) SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint. Cell Cycle 8 628-38 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22692201-1] 1.0 ^1.1 Sengerová, B et al. (2012) Characterization of the human SNM1A and SNM1B/Apollo DNA repair exonucleases. J. Biol. Chem. 287 26254-67 PubMed GONUTS page

[PMID:20479256-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Touzot, F et al. (2010) Function of Apollo (SNM1B) at telomere highlighted by a splice variant identified in a patient with Hoyeraal-Hreidarsson syndrome. Proc. Natl. Acad. Sci. U.S.A. 107 10097-102 PubMed GONUTS page

[PMID:18202258-3] Chen, Y et al. (2008) A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. Science 319 1092-6 PubMed GONUTS page

[PMID:24270157-4] Grolimund, L et al. (2013) A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Nat Commun 4 2848 PubMed GONUTS page

[PMID:19135898-5] Déjardin, J & Kingston, RE (2009) Purification of proteins associated with specific genomic Loci. Cell 136 175-86 PubMed GONUTS page

[PMID:16730175-6] 6.0 ^6.1 ^6.2 Lenain, C et al. (2006) The Apollo 5' exonuclease functions together with TRF2 to protect telomeres from DNA repair. Curr. Biol. 16 1303-10 PubMed GONUTS page

[PMID:20655466-7] 7.0 ^7.1 ^7.2 Ye, J et al. (2010) TRF2 and apollo cooperate with topoisomerase 2alpha to protect human telomeres from replicative damage. Cell 142 230-42 PubMed GONUTS page

[PMID:19197158-8] 8.0 ^8.1 Liu, L et al. (2009) SNM1B/Apollo interacts with astrin and is required for the prophase cell cycle checkpoint. Cell Cycle 8 628-38 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:DCR1B

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