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DROME:CHD1

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Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) Chd1
Protein Name(s) Chromodomain-helicase-DNA-binding protein 1

CHD-1 ATP-dependent helicase Chd1

External Links
UniProt Q7KU24
EMBL L77907
AE014134
PIR T13944
RefSeq NP_477197.1
UniGene Dm.2960
ProteinModelPortal Q7KU24
SMR Q7KU24
BioGrid 59725
IntAct Q7KU24
PaxDb Q7KU24
PRIDE Q7KU24
EnsemblMetazoa FBtr0077674
GeneID 33505
KEGG dme:Dmel_CG3733
UCSC CG3733-RA
CTD 1105
FlyBase FBgn0250786
eggNOG COG0553
GeneTree ENSGT00760000119067
InParanoid Q7KU24
KO K11367
OrthoDB EOG7NPFSB
PhylomeDB Q7KU24
ChiTaRS Chd1
GenomeRNAi 33505
NextBio 783939
Proteomes UP000000803
Bgee Q7KU24
ExpressionAtlas Q7KU24
GO GO:0005634
GO:0005705
GO:0005703
GO:0005524
GO:0008026
GO:0003682
GO:0003677
GO:0004386
GO:0035042
GO:0007476
GO:0048477
GO:0006355
GO:0006351
Gene3D 3.40.50.300
InterPro IPR023780
IPR000953
IPR016197
IPR023779
IPR002464
IPR025260
IPR014001
IPR001650
IPR027417
IPR000330
Pfam PF00385
PF13907
PF00271
PF00176
SMART SM00298
SM00487
SM00490
SUPFAM SSF52540
SSF54160
PROSITE PS00598
PS50013
PS00690
PS51192
PS51194

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0043044

ATP-dependent chromatin remodeling

PMID:23533627[1]

IMP: Inferred from Mutant Phenotype

P

Figure 1A indicates that a loss of CHD1 results in defective polytene chromosomes. Figure 3 shows that a lack in CHD1 can led to increased levels of HP1a and the H3K9me2 repressive chromatin. Fig 4 shows that an increase in CHD1 leads to disruption in chromosome structure, whereas a decrease of the ATP inactivated form of CHD1 didn't have much affect.

complete
CACAO 7143

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0003676

nucleic acid binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002464

F

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003682

chromatin binding

PMID:8692958[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004386

helicase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0347

F

Seeded From UniProt

complete

GO:0004386

helicase activity

PMID:10908586[3]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0004386

helicase activity

PMID:8692958[2]

ISS: Inferred from Sequence or Structural Similarity

MGI:MGI:88393

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000330
InterPro:IPR002464

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005694

chromosome

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0158

C

Seeded From UniProt

complete

GO:0005694

chromosome

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0468

C

Seeded From UniProt

complete

GO:0005703

polytene chromosome puff

PMID:8692958[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005705

polytene chromosome interband

PMID:8692958[2]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0007476

imaginal disc-derived wing morphogenesis

PMID:18202396[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008026

ATP-dependent helicase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR002464

F

Seeded From UniProt

complete

GO:0016568

chromatin modification

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

GO:0016787

hydrolase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

GO:0035042

fertilization, exchange of chromosomal proteins

PMID:17717186[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043044

ATP-dependent chromatin remodeling

PMID:23533627[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0048477

oogenesis

PMID:18202396[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Bugga, L et al. (2013) The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2. PLoS ONE 8 e59496 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Stokes, DG et al. (1996) CHD1 is concentrated in interbands and puffed regions of Drosophila polytene chromosomes. Proc. Natl. Acad. Sci. U.S.A. 93 7137-42 PubMed GONUTS page
  3. Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
  4. 4.0 4.1 McDaniel, IE et al. (2008) Investigations of CHD1 function in transcription and development of Drosophila melanogaster. Genetics 178 583-7 PubMed GONUTS page
  5. Konev, AY et al. (2007) CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo. Science 317 1087-90 PubMed GONUTS page