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DROME:CHD1
Contents
| Species (Taxon ID) | Drosophila melanogaster (Fruit fly). (7227) | |
| Gene Name(s) | Chd1 | |
| Protein Name(s) | Chromodomain-helicase-DNA-binding protein 1
CHD-1 ATP-dependent helicase Chd1 | |
| External Links | ||
| UniProt | Q7KU24 | |
| EMBL | L77907 AE014134 | |
| PIR | T13944 | |
| RefSeq | NP_477197.1 | |
| UniGene | Dm.2960 | |
| ProteinModelPortal | Q7KU24 | |
| SMR | Q7KU24 | |
| BioGrid | 59725 | |
| IntAct | Q7KU24 | |
| PaxDb | Q7KU24 | |
| PRIDE | Q7KU24 | |
| EnsemblMetazoa | FBtr0077674 | |
| GeneID | 33505 | |
| KEGG | dme:Dmel_CG3733 | |
| UCSC | CG3733-RA | |
| CTD | 1105 | |
| FlyBase | FBgn0250786 | |
| eggNOG | COG0553 | |
| GeneTree | ENSGT00760000119067 | |
| InParanoid | Q7KU24 | |
| KO | K11367 | |
| OrthoDB | EOG7NPFSB | |
| PhylomeDB | Q7KU24 | |
| ChiTaRS | Chd1 | |
| GenomeRNAi | 33505 | |
| NextBio | 783939 | |
| Proteomes | UP000000803 | |
| Bgee | Q7KU24 | |
| ExpressionAtlas | Q7KU24 | |
| GO | GO:0005634 GO:0005705 GO:0005703 GO:0005524 GO:0008026 GO:0003682 GO:0003677 GO:0004386 GO:0035042 GO:0007476 GO:0048477 GO:0006355 GO:0006351 | |
| Gene3D | 3.40.50.300 | |
| InterPro | IPR023780 IPR000953 IPR016197 IPR023779 IPR002464 IPR025260 IPR014001 IPR001650 IPR027417 IPR000330 | |
| Pfam | PF00385 PF13907 PF00271 PF00176 | |
| SMART | SM00298 SM00487 SM00490 | |
| SUPFAM | SSF52540 SSF54160 | |
| PROSITE | PS00598 PS50013 PS00690 PS51192 PS51194 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0140658 |
ATP-dependent chromatin remodeler activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Figure 1A indicates that a loss of CHD1 results in defective polytene chromosomes. Figure 3 shows that a lack in CHD1 can led to increased levels of HP1a and the H3K9me2 repressive chromatin. Fig 4 shows that an increase in CHD1 leads to disruption in chromosome structure, whereas a decrease of the ATP inactivated form of CHD1 didn't have much affect. GO term changed per Ticket-3833 Dsiegele (talk) 10:39, 29 June 2021 (CDT) |
complete | ||||
|
involved_in |
GO:0140658 |
ATP-dependent chromatin remodeler activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt GO ID changed per Ticket-3833 Dsiegele (talk) 10:39, 29 June 2021 (CDT) |
complete | |||
|
involved_in |
GO:0007476 |
imaginal disc-derived wing morphogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0048477 |
oogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0035042 |
fertilization, exchange of chromosomal proteins |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0043486 |
histone exchange |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
Missing: with/from | |||
|
part_of |
GO:0005703 |
polytene chromosome puff |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
MGI:MGI:88393 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005705 |
polytene chromosome interband |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005694 |
chromosome |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004386 |
helicase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016787 |
hydrolase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Bugga, L et al. (2013) The Drosophila melanogaster CHD1 chromatin remodeling factor modulates global chromosome structure and counteracts HP1a and H3K9me2. PLoS ONE 8 e59496 PubMed GONUTS page
- ↑ 2.0 2.1 McDaniel, IE et al. (2008) Investigations of CHD1 function in transcription and development of Drosophila melanogaster. Genetics 178 583-7 PubMed GONUTS page
- ↑ 3.0 3.1 Konev, AY et al. (2007) CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo. Science 317 1087-90 PubMed GONUTS page
- ↑ Lasko, P (2000) The drosophila melanogaster genome: translation factors and RNA binding proteins. J. Cell Biol. 150 F51-6 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 Stokes, DG et al. (1996) CHD1 is concentrated in interbands and puffed regions of Drosophila polytene chromosomes. Proc. Natl. Acad. Sci. U.S.A. 93 7137-42 PubMed GONUTS page
