HUMAN:P53

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TP53 (synonyms: P53)
Protein Name(s)	Cellular tumor antigen p53 Antigen NY-CO-13 Phosphoprotein p53 Tumor suppressor p53
External Links
UniProt	P04637
EMBL	X02469 M13121 M13112 M13113 M13114 M13115 M13116 M13117 M13118 M13119 M13120 K03199 M14694 M14695 M22898 M22882 M22883 M22884 M22887 M22888 M22894 M22895 M22896 M22897 X01405 X60011 X60012 X60013 X60014 X60015 X60016 X60017 X60018 X60019 X60020 AF307851 DQ186648 DQ186649 DQ186650 DQ186651 DQ186652 DQ191317 DQ286964 X54156 U94788 AY838896 AF135121 AF135120 AF136271 AF136270 AB082923 AK312568 AC007421 AC087388 CH471108 CH471108 BC003596 AY429684 AY390341 AY359814 U63714 AF209136 AF209128 AF209129 AF209130 AF209131 AF209132 AF209133 AF209134 AF209135 AF209148 AF209149 AF209150 AF209151 AF209152 AF209153 AF209154 AF209155 AF209156 AF210309 AF210308 AF210310 AF240684 AF240685 AY270155
CCDS	CCDS11118.1 CCDS45605.1 CCDS45606.1 CCDS73966.1 CCDS73967.1 CCDS73968.1 CCDS73969.1 CCDS73970.1 CCDS73971.1
PIR	A25224
RefSeq	NP_000537.3 NP_001119584.1 NP_001119585.1 NP_001119586.1 NP_001119587.1 NP_001119588.1 NP_001119589.1 NP_001119590.1 NP_001263624.1 NP_001263625.1 NP_001263626.1 NP_001263627.1 NP_001263628.1 NP_001263689.1 NP_001263690.1
UniGene	Hs.437460 Hs.740601
PDB	1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2FOJ 2FOO 2GS0 2H1L 2H2D 2H2F 2H4F 2H4H 2H4J 2H59 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 2K8F 2L14 2LY4 2MEJ 2OCJ 2PCX 2RUK 2VUK 2WGX 2X0U 2X0V 2X0W 2XWR 2YBG 2YDR 2Z5S 2Z5T 3D05 3D06 3D07 3D08 3D09 3D0A 3DAB 3DAC 3IGK 3IGL 3KMD 3KZ8 3LW1 3OQ5 3PDH 3Q01 3Q05 3Q06 3SAK 3TG5 3TS8 3ZME 4AGL 4AGM 4AGN 4AGO 4AGP 4AGQ 4BUZ 4BV2 4HFZ 4HJE 4IBQ 4IBS 4IBT 4IBU 4IBV 4IBW 4IBY 4IBZ 4IJT 4KVP 4LO9 4LOE 4LOF 4MZI 4MZR 4QO1
PDBsum	1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YC5 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2F1X 2FEJ 2FOJ 2FOO 2GS0 2H1L 2H2D 2H2F 2H4F 2H4H 2H4J 2H59 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 2K8F 2L14 2LY4 2MEJ 2OCJ 2PCX 2RUK 2VUK 2WGX 2X0U 2X0V 2X0W 2XWR 2YBG 2YDR 2Z5S 2Z5T 3D05 3D06 3D07 3D08 3D09 3D0A 3DAB 3DAC 3IGK 3IGL 3KMD 3KZ8 3LW1 3OQ5 3PDH 3Q01 3Q05 3Q06 3SAK 3TG5 3TS8 3ZME 4AGL 4AGM 4AGN 4AGO 4AGP 4AGQ 4BUZ 4BV2 4HFZ 4HJE 4IBQ 4IBS 4IBT 4IBU 4IBV 4IBW 4IBY 4IBZ 4IJT 4KVP 4LO9 4LOE 4LOF 4MZI 4MZR 4QO1
DisProt	DP00086
ProteinModelPortal	P04637
SMR	P04637
BioGrid	113010
DIP	DIP-368N
IntAct	P04637
MINT	MINT-91013
BindingDB	P04637
ChEMBL	CHEMBL2221344
DrugBank	DB00945
TCDB	1.C.110.1.1
PhosphoSite	P04637
DMDM	269849759
SWISS-2DPAGE	P04637
MaxQB	P04637
PaxDb	P04637
PRIDE	P04637
DNASU	7157
Ensembl	ENST00000269305 ENST00000420246 ENST00000445888 ENST00000455263 ENST00000504290 ENST00000504937 ENST00000510385 ENST00000610292 ENST00000610538 ENST00000617185 ENST00000619485 ENST00000620739 ENST00000622645
GeneID	7157
KEGG	hsa:7157
UCSC	uc002gii.2 uc010cnf.2 uc010cng.2 uc010cnh.2 uc010cni.2
CTD	7157
GeneCards	GC17M007565
GeneReviews	TP53
HGNC	HGNC:11998
HPA	CAB002973 CAB039238 CAB039239 HPA051244
MIM	133239 151623 191170 202300 211980 260500 275355 614740
neXtProt	NX_P04637
Orphanet	1501 67038 3318 1333 251579 251576 524 2807 99860
PharmGKB	PA36679
eggNOG	NOG80479
GeneTree	ENSGT00390000015092
HOVERGEN	HBG005201
InParanoid	P04637
KO	K04451
OMA	SQKTYPG
PhylomeDB	P04637
TreeFam	TF106101
Reactome	REACT_118568 REACT_1194 REACT_121 REACT_169121 REACT_169185 REACT_169325 REACT_169436 REACT_20549 REACT_24970 REACT_309
SignaLink	P04637
ChiTaRS	TP53
EvolutionaryTrace	P04637
GeneWiki	P53
GenomeRNAi	7157
NextBio	28006
PMAP-CutDB	P04637
PRO	PR:P04637
Proteomes	UP000005640
Bgee	P04637
ExpressionAtlas	P04637
Genevestigator	P04637
GO	GO:0000785 GO:0005737 GO:0005829 GO:0005783 GO:0005759 GO:0005739 GO:0000790 GO:0016363 GO:0005730 GO:0005654 GO:0005634 GO:0016605 GO:0043234 GO:0005657 GO:0005524 GO:0051087 GO:0003682 GO:0005507 GO:0003684 GO:0003677 GO:0019899 GO:0035035 GO:0035033 GO:0042802 GO:0002039 GO:0002020 GO:0046982 GO:0019901 GO:0047485 GO:0051721 GO:0019903 GO:0030971 GO:0001077 GO:0000979 GO:0001085 GO:0001228 GO:0003700 GO:0008134 GO:0044212 GO:0031625 GO:0008270 GO:0006915 GO:0002326 GO:0006284 GO:0007596 GO:0007569 GO:0007050 GO:0030154 GO:0008283 GO:0034613 GO:0006974 GO:0035690 GO:0042149 GO:0071456 GO:0071479 GO:0034644 GO:0021549 GO:0031497 GO:0008340 GO:0030330 GO:0006977 GO:0006978 GO:0000733 GO:0006302 GO:0048568 GO:0006983 GO:0007369 GO:0001701 GO:0097193 GO:0072332 GO:0042771 GO:0071850 GO:0031571 GO:0035264 GO:0007275 GO:0070266 GO:0043066 GO:0030308 GO:0008285 GO:0008156 GO:0048147 GO:0051097 GO:1901525 GO:0007406 GO:2000378 GO:0000122 GO:0045892 GO:0030512 GO:0051402 GO:0007219 GO:0006289 GO:0097252 GO:0090403 GO:0043065 GO:0010666 GO:0090343 GO:0071158 GO:0031065 GO:2001244 GO:0035794 GO:0043525 GO:0050731 GO:1900740 GO:0032461 GO:2000379 GO:0090200 GO:0070245 GO:0045944 GO:0045893 GO:0006461 GO:0000060 GO:0008104 GO:0051262 GO:0007265 GO:0042981 GO:0046902 GO:1902108 GO:0034103 GO:0006355 GO:0001836 GO:0090399 GO:0046677 GO:0010332 GO:0002931 GO:0009651 GO:0010165 GO:0009303 GO:0001756 GO:0033077 GO:0002360 GO:0002309 GO:0007179 GO:0016032
Gene3D	2.60.40.720 4.10.170.10
InterPro	IPR008967 IPR012346 IPR011615 IPR010991 IPR013872 IPR002117
PANTHER	PTHR11447
Pfam	PF00870 PF08563 PF07710
PRINTS	PR00386
SUPFAM	SSF47719 SSF49417
PROSITE	PS00348

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016605	PML body		ECO:0000314			C		Source: BHF-UCL	Missing: reference
	GO:0043234	protein complex		ECO:0000314			C		Source: BHF-UCL	Missing: reference
	GO:0003682	chromatin binding		ECO:0000314			F		Source: MGI	Missing: reference
	GO:0010843	promoter binding		ECO:0000314			F		Source: BHF-UCL	Missing: reference
	GO:0008134	transcription factor binding		ECO:0000021			F		Source: BHF-UCL	Missing: with/from, reference
	GO:0007050	cell cycle arrest		ECO:0000314			P		Source: BHF-UCL	Missing: reference
	GO:0042149	cellular response to glucose starvation		ECO:0000314			P		Source: MGI	Missing: reference
	GO:0006978	DNA damage response, signal transduction by...		ECO:0000315			P		Source: BHF-UCL	Missing: reference
	GO:0042771	DNA damage response, signal transduction by...		ECO:0000314			P		Source: MGI	Missing: reference
	GO:0006983	ER overload response		ECO:0000314			P		Source: MGI	Missing: reference
	GO:0031571	G1/S DNA damage checkpoint		ECO:0000315			P		Source: BHF-UCL	Missing: reference
	GO:0010552	positive regulation of gene-specific transc...		ECO:0000314			P		Source: BHF-UCL	Missing: reference
	GO:0007265	Ras protein signal transduction		ECO:0000270			P		Source: BHF-UCL	Missing: reference
	GO:0010332	response to gamma radiation		ECO:0000315			P		Source: BHF-UCL	Missing: reference
	GO:0000075	cell cycle checkpoint	Reactome:REACT_1538	ECO:0000314			P		Mutations in the p53 gene have been associated with human tumors including osteosarcomas. This study shows that the over expression of the gene encoding wild-type p53 blocks the growth of osteosarcoma cells. The growth arrest was determined to be due to an inability of the transfected cells to progress to S phase. This suggests that the told of p53 gene as an antioncogene may be in controlling the cell cycle in a fashion analogous to the check point control genes in Saccharomyces cerevisiae. Immunofluorescence and Southern blots were used.	complete CACAO 9306
involved_in	GO:0051123	RNA polymerase II preinitiation complex assembly	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0000988	protein binding transcription factor activity	PMID:16131611^[2]	ECO:0000314			F		Figure 9-C	complete CACAO 5189
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	PMID:21867493^[4]	ECO:0000315			P		Figure 2C shows that 14-3-3gamma protein was suppressed when cells were infected with wt-p53-adenovirus. Figure 2D shows that expression of 14-3-3gamma protein was increased when p53 was suppressed. Figure 3 shows that p53 binds to 14-3-3gamma promoter region and negatively regulates transcription of 14-3-3gamma being expressed.	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR011615 InterPro:IPR012346	F		Seeded From UniProt	complete
	GO:0002347	response to tumor cell	PMID:23359208^[5]	ECO:0000314			P		Figure 4B western blot shows increased p53 expression present in LNCaP cells.	complete CACAO 6410
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P10361	F		Seeded From UniProt	complete
	GO:0002347	response to tumor cell	PMID:23300534^[6]	ECO:0000314			P		Figure 4A and Figure 4D show accumulation of p53 in OVCAR-3 cells as it inhibits proinflammatory chemokine expression in these ovarian cancer cells.	complete CACAO 6411
enables	GO:1990841	promoter-specific chromatin binding	PMID:24356969^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
	GO:0016032	viral reproduction	PMID:22574148^[8]	ECO:0000315			P		Figure 7	complete CACAO 6713
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24356969^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0043066	negative regulation of apoptotic process	PMID:20124405^[9]	ECO:0000315			P		Figure 1 shows that GRK5 inhibits apoptosis in osteosarcoma cells	complete CACAO 6918
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:24356969^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0008285	negative regulation of cell proliferation	PMID:22783376^[10]	ECO:0000314			P		Figure 3A: Cell proliferation assay data was performed at 48 h to examine the effect of cytoplasmically localized wild-type p53 and the S121F mutant on cell proliferation. The data resulted with both wild-type p53 and the S121F mutant inhibiting cell proliferation.	complete CACAO 7626
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:17145718^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952) has_regulation_target:(ENSEMBL:ENSG00000087088)	Seeded From UniProt	complete
	GO:0003677	DNA binding	PMID:23555710^[12]	ECO:0000315			F		Figure 1 A shows hot spot mutations on full lenght p53. 1 B shows that open circle DNA was not bound by p53	complete CACAO 7643
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17145718^[11]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000087088)	Seeded From UniProt	complete
	GO:0003677	DNA binding	PMID:23555710^[12]	ECO:0000315			F		Figure 3B shows that without the critical role of CTDBS hot spot mutp53 proteins R175H, R273H and R248W are unable to selectively recognize scDNA.	complete CACAO 7722
involved_in	GO:0060218	hematopoietic stem cell differentiation	PMID:30146126^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0003677	DNA binding	PMID:23555710^[12]	ECO:0000315			F		Figure 7 shows that DNA topology influences the mutp53-driven repression on the system of BAX and MSP/MST1 promoters, regulated by mutp53s in H1299 and Saos2 cells.	complete CACAO 7788
involved_in	GO:0002244	hematopoietic progenitor cell differentiation	PMID:30146126^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:20378837^[14]	ECO:0000314			P		figure 2 show that p53 increases GLS2 transcription from 2 p53 inducible cell lines. After p53 had been induced, the levels of GLS2 mRNA increased by 35 fold in one line and 14 fold in the other as measured by real-time-PCR	complete CACAO 7888
involved_in	GO:0048539	bone marrow development	PMID:30146126^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:22955915^[15]	ECO:0000315			P		Figure 1 shows that a mutation in the p53 results in mutations in the DNA-binding domain, in DLBCL (Diffuse large B-cell lymphoma) patients Figure 2 shows that a mutation of the p53 results in poor survival rates for those with DLBCL	complete CACAO 8005
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10361	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:20725088^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:O75677) occurs_in:(CL:0000066)\|has_direct_input(UniProtKB:P38936) occurs_in:(CL:0000066)	Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17145718^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q12837	C	regulates_transcription_of:(ENSEMBL:ENSG00000087088)	Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:19011621^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:19011621^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19011621^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19011621^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952) part_of:(GO:0051123)	Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:27031958^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097718	disordered domain specific binding	PMID:15629713^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16665	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:25417702^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:23629966^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:23629966^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:15565177^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902895	positive regulation of pri-miRNA transcription by RNA polymerase II	PMID:20546595^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002548) regulates_transcription_of:(ENSEMBL:ENSG00000284190)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10361	P	regulates_o_occurs_in:(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000170345)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000120738)\|regulates_o_occurs_in(CL:0002609) regulates_expression_of:(ENSEMBL:ENSG00000107984)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16479015^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:15358771^[25]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P08238	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15358771^[25]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15629713^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:15629713^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051289	protein homotetramerization	PMID:15629713^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15629713^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16479015^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	PMID:16479015^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16479015^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009299	mRNA transcription	PMID:16479015^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(ENSEMBL:ENSG00000124762) coincident_with:(SO:0001668) exists_during:(GO:0034644)	Seeded From UniProt	complete
enables	GO:0001094	TFIID-class transcription factor complex binding	PMID:24289924^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21675	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:24289924^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0034644) occurs_at:(SO:0000167) has_input:(ENSEMBL:ENSG00000124762)	Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:25417702^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9H3D4	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	PMID:25417702^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15350	F		Seeded From UniProt	complete
involved_in	GO:0051974	negative regulation of telomerase activity	PMID:10597287^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006914	autophagy	PMID:23629966^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	PMID:23629966^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23629966^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:23629966^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001046	core promoter sequence-specific DNA binding	PMID:23629966^[21]	ECO:0000314	direct assay evidence used in manual assertion		F	happens_during:(GO:0060333)	Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:12730672^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072331	signal transduction by p53 class mediator	PMID:15314173^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072717	cellular response to actinomycin D	PMID:15314173^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	PMID:15314173^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15314173^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:19160485^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	PMID:16213212^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20332243^[31]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000276365)	Seeded From UniProt	complete
involved_in	GO:1900119	positive regulation of execution phase of apoptosis	PMID:14985081^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043621	protein self-association	PMID:14985081^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P	has_regulation_target:(UniProtKB:Q9BXH1)\|has_regulation_target:(UniProtKB:Q13794)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20378837^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	PMID:22783376^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PMID:17310983^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:17310983^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:17310983^[33]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17310983^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:16213212^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:16213212^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	PMID:16213212^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	PMID:16213212^[30]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003730	mRNA 3'-UTR binding	PMID:16213212^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:24652652^[34]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:24652652^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	F		Seeded From UniProt	complete
involved_in	GO:0048512	circadian behavior	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0043153	entrainment of circadian clock by photoperiod	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:24051492^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20124405^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	PMID:22574148^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:17121812^[36]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q969K3	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:18382127^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q969K3	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:20562916^[38]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9BV47	F		Seeded From UniProt	complete
involved_in	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA	PMID:26100857^[39]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSG00000284357)	Seeded From UniProt	complete
involved_in	GO:2000379	positive regulation of reactive oxygen species metabolic process	PMID:20160708^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090403	oxidative stress-induced premature senescence	PMID:19951988^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090399	replicative senescence	PMID:19951988^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PMID:12172011^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	PMID:20160708^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070245	positive regulation of thymocyte apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:19749791^[43]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17146433^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(ENSEMBL:ENSG00000102760)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18549481^[45]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11672523^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18549481^[45]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:19749791^[43]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:17996705^[47]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:15710329^[48]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:9529249^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031571	mitotic G1 DNA damage checkpoint	PMID:7958916^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	PMID:23027130^[51]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16288	F		Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:20160708^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	PMID:15149599^[52]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:17805299^[53]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:12006491^[54]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0016604	nuclear body	PMID:10360174^[55]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	PMID:7958916^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15053879^[56]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P21675	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:15705871^[57]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28360	F		Seeded From UniProt	complete
involved_in	GO:0007265	Ras protein signal transduction	PMID:9054499^[58]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:7958916^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:15149599^[52]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	PMID:7958916^[50]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:15710329^[48]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005669	transcription factor TFIID complex	PMID:15053879^[56]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18756595^[59]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18549481^[45]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:17146433^[44]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(ENSEMBL:ENSG00000102760) occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:18549481^[45]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q5HZG4	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:22521434^[60]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:17805299^[53]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:15710329^[48]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19749791^[43]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P02340	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:14963330^[61]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097252	oligodendrocyte apoptotic process	PMID:7720704^[62]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:14963330^[61]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:12667443^[63]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PMID:16322561^[64]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:20810912^[65]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(CL:0000525)	Seeded From UniProt	complete
involved_in	GO:0071158	positive regulation of cell cycle arrest	PMID:21471221^[66]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	PMID:17245430^[67]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P63151	F		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:18086682^[68]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10809	F		Seeded From UniProt	complete
involved_in	GO:0048147	negative regulation of fibroblast proliferation	PMID:10962037^[69]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:11861836^[70]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P03406	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:10837489^[71]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07820	F		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	PMID:20810912^[65]	ECO:0000270	expression pattern evidence used in manual assertion		P	occurs_in:(CL:0000525)	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20959462^[72]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20096447^[73]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16322561^[64]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17403783^[74]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:12667443^[63]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:20959462^[72]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:17403783^[74]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:21471221^[66]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035690	cellular response to drug	PMID:20810912^[65]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	PMID:10518217^[75]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
enables	GO:0035035	histone acetyltransferase binding	PMID:9194565^[76]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q09472	F		Seeded From UniProt	complete
involved_in	GO:0032461	positive regulation of protein oligomerization	PMID:12667443^[63]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q07812)\|happens_during(GO:0008637)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:18382127^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8WZ73	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:17121812^[36]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8WZ73	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:9529249^[49]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:10415337^[77]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9NS56	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:8875929^[78]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00987	F		Seeded From UniProt	complete
involved_in	GO:0031497	chromatin assembly	PMID:16322561^[64]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	PMID:8986812^[79]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21317932^[80]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60285	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:11546806^[81]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96S44	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11672523^[46]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96EB6	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:20173098^[82]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6PCD5	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:15577914^[83]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15392	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:7663514^[84]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P19447	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:11781842^[85]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54132	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:15044383^[86]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q7Z2E3	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:10666337^[87]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P11388	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:10666337^[87]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q02880	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:7663514^[84]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P18074	F		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:22869143^[88]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:11080164^[89]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:19505873^[90]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q01664	F		Seeded From UniProt	complete
involved_in	GO:0008104	protein localization	PMID:16507995^[91]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	PMID:12080348^[92]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	PMID:10065150^[93]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:10962037^[69]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:17938203^[94]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:12915590^[95]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:7587074^[96]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006289	nucleotide-excision repair	PMID:7663514^[84]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:14963330^[61]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:12667443^[63]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20810912^[65]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000525)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20096447^[73]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7720704^[62]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:12080348^[92]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:11080164^[89]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:12915590^[95]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14963330^[61]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16322561^[64]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19234109^[97]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20810912^[65]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000525)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17403783^[74]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20096447^[73]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16507995^[91]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7720704^[62]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:8183576^[98]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005507	copper ion binding	PMID:7824276^[99]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:7587074^[96]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16322561^[64]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:2144364^[100]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:11923872^[101]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q93009	F		Seeded From UniProt	complete
involved_in	GO:0000733	DNA strand renaturation	PMID:8183576^[98]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16061649^[102]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8WWK9	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17599062^[103]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	PMID:14744935^[104]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:14744935^[104]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:14654789^[105]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	PMID:14744935^[104]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006983	ER overload response	PMID:14744935^[104]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:14744935^[104]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:24101517^[106]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:24101517^[106]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14744935^[104]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24101517^[106]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14744935^[104]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:17599062^[103]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20004160^[107]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19667193^[108]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:19339993^[109]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18087040^[110]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17620598^[111]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:17612295^[112]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16461914^[113]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16291740^[114]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:14985081^[32]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25609649^[115]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25402006^[116]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22972749^[117]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22653443^[118]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21988832^[119]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21522129^[120]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21178074^[121]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20364130^[122]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20159469^[123]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04637	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000772	regulation of cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:2000269	regulation of fibroblast apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:1990144	intrinsic apoptotic signaling pathway in response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:1904024	negative regulation of glucose catabolic process to lactate via pyruvate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:1902253	regulation of intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:1901525	negative regulation of mitophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
enables	GO:0097371	MDM2/MDM4 family protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
involved_in	GO:0090343	positive regulation of cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0072363	regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0071850	mitotic cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0071494	cellular response to UV-C	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0071479	cellular response to ionizing radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0070245	positive regulation of thymocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0070243	regulation of thymocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0062100	positive regulation of programmed necrotic cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0060411	cardiac septum morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0048568	embryonic organ development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0048512	circadian behavior	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0048147	negative regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0045861	negative regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0043523	regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0043516	regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0043504	mitochondrial DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0043153	entrainment of circadian clock by photoperiod	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	C		Seeded From UniProt	complete
involved_in	GO:0035794	positive regulation of mitochondrial membrane permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0035264	multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
enables	GO:0035033	histone deacetylase regulator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0034103	regulation of tissue remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
involved_in	GO:0031571	mitotic G1 DNA damage checkpoint	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0031065	positive regulation of histone deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0030330	DNA damage response, signal transduction by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0021549	cerebellum development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0010666	positive regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0009792	embryo development ending in birth or egg hatching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0009651	response to salt stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0009303	rRNA transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0008156	negative regulation of DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0007406	negative regulation of neuroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0007369	gastrulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0007179	transforming growth factor beta receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0006302	double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	C		Seeded From UniProt	complete
part_of	GO:0005657	replication fork	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0002360	T cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0002326	B cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0002309	T cell proliferation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
enables	GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P02340 ensembl:ENSMUSP00000104298	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR012346	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117 InterPro:IPR008967 InterPro:IPR012346	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002117	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011615	F		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010991 InterPro:IPR036674	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034613	cellular protein localization	PMID:15340061^[124]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:15340061^[124]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15340061^[124]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:15340061^[124]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16131611^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	PMID:16462759^[125]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051262	protein tetramerization	PMID:15116721^[126]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051097	negative regulation of helicase activity	PMID:7663514^[84]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	PMID:15116721^[126]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:10065150^[93]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:10065150^[93]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:10065153^[127]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006284	base-excision repair	PMID:15116721^[126]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902749	regulation of cell cycle G2/M phase transition	Reactome:R-HSA-8852276	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-139915 Reactome:R-HSA-111448	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	Reactome:R-HSA-8852351	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	Reactome:R-HSA-5633008	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016579	protein deubiquitination	Reactome:R-HSA-5688426	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Reactome:R-HSA-69563 Reactome:R-HSA-6791312	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-8852354 Reactome:R-HSA-8852351 Reactome:R-HSA-6793685 Reactome:R-HSA-5690843	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-992753 Reactome:R-HSA-8952128 Reactome:R-HSA-8852351 Reactome:R-HSA-8852337 Reactome:R-HSA-69685 Reactome:R-HSA-6811508 Reactome:R-HSA-6811479 Reactome:R-HSA-6806419 Reactome:R-HSA-6806417 Reactome:R-HSA-6806413 Reactome:R-HSA-6806412 Reactome:R-HSA-6806408 Reactome:R-HSA-6805755 Reactome:R-HSA-6805740 Reactome:R-HSA-6805730 Reactome:R-HSA-6805638 Reactome:R-HSA-6805620 Reactome:R-HSA-6805479 Reactome:R-HSA-6805470 Reactome:R-HSA-6805399 Reactome:R-HSA-6805285 Reactome:R-HSA-6805276 Reactome:R-HSA-6805126 Reactome:R-HSA-6805122 Reactome:R-HSA-6805109 Reactome:R-HSA-6805103 Reactome:R-HSA-6805059 Reactome:R-HSA-6805035 Reactome:R-HSA-6804998 Reactome:R-HSA-6804996 Reactome:R-HSA-6804879 Reactome:R-HSA-6804762 Reactome:R-HSA-6804441 Reactome:R-HSA-6804425 Reactome:R-HSA-6804402 Reactome:R-HSA-6804383 Reactome:R-HSA-6804379 Reactome:R-HSA-6804242 Reactome:R-HSA-6804191 Reactome:R-HSA-6804188 Reactome:R-HSA-6803935 Reactome:R-HSA-6803914 Reactome:R-HSA-6803858 Reactome:R-HSA-6803801 Reactome:R-HSA-6803719 Reactome:R-HSA-6803425 Reactome:R-HSA-6803391 Reactome:R-HSA-6802165 Reactome:R-HSA-6801641 Reactome:R-HSA-6801355 Reactome:R-HSA-6801209 Reactome:R-HSA-6801166 Reactome:R-HSA-6801087 Reactome:R-HSA-6800836 Reactome:R-HSA-6800279 Reactome:R-HSA-6800253 Reactome:R-HSA-6800042 Reactome:R-HSA-6799815 Reactome:R-HSA-6799777 Reactome:R-HSA-6799761 Reactome:R-HSA-6799462 Reactome:R-HSA-6799431 Reactome:R-HSA-6799418 Reactome:R-HSA-6799409 Reactome:R-HSA-6799332 Reactome:R-HSA-6799246 Reactome:R-HSA-6798615 Reactome:R-HSA-6798374 Reactome:R-HSA-6798304 Reactome:R-HSA-6798282 Reactome:R-HSA-6798138 Reactome:R-HSA-6798129 Reactome:R-HSA-6798082 Reactome:R-HSA-6798020 Reactome:R-HSA-6797993 Reactome:R-HSA-6797766 Reactome:R-HSA-6796649 Reactome:R-HSA-6793685 Reactome:R-HSA-6791409 Reactome:R-HSA-6791387 Reactome:R-HSA-6791349 Reactome:R-HSA-6791327 Reactome:R-HSA-6791302 Reactome:R-HSA-6791285 Reactome:R-HSA-6789960 Reactome:R-HSA-5693609 Reactome:R-HSA-5689973 Reactome:R-HSA-5689950 Reactome:R-HSA-5633460 Reactome:R-HSA-5633414 Reactome:R-HSA-5633295 Reactome:R-HSA-5632939 Reactome:R-HSA-5632914 Reactome:R-HSA-5632887 Reactome:R-HSA-5632759 Reactome:R-HSA-5629187 Reactome:R-HSA-5628899 Reactome:R-HSA-5628871 Reactome:R-HSA-4647593 Reactome:R-HSA-4395236 Reactome:R-HSA-4331340 Reactome:R-HSA-4331331 Reactome:R-HSA-3786258 Reactome:R-HSA-3700997 Reactome:R-HSA-3700981 Reactome:R-HSA-3239014 Reactome:R-HSA-3222259 Reactome:R-HSA-3222237 Reactome:R-HSA-3222128 Reactome:R-HSA-3222116 Reactome:R-HSA-3222093 Reactome:R-HSA-3222020 Reactome:R-HSA-3222006 Reactome:R-HSA-3221982 Reactome:R-HSA-3215310 Reactome:R-HSA-3215251 Reactome:R-HSA-3215152 Reactome:R-HSA-2997706 Reactome:R-HSA-264435	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1210	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
part_of	GO:0005759	mitochondrial matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0170	C		Seeded From UniProt	complete
	GO:1905856	negative regulation of pentose-phosphate shunt	PMID:21336310^[128]	ECO:0000315			P		Figure 1a shows that in p53-/- cells there is a significant increase in oxidative pentose phosphate pathway flux compared to p53+/+ cells in humans Organism: Human	complete CACAO 13284
	GO:0045833	negative regulation of lipid metabolic process	PMID:21336310^[128]	ECO:0000315			P		Figure 2c shows that in p53-/- cells there is a significant increase in lipid formation compared to p53+/+ cells with or without DHEA in humans Organism: Human	complete CACAO 13285
edit table

Notes

Viral Reproduction PMCID:PMC3344861 converted to PMID:22574148

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 Wu, Y et al. (2014) Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. Mol. Cell 53 63-74 PubMed GONUTS page
↑ ^2.00 ^2.01 ^2.02 ^2.03 ^2.04 ^2.05 ^2.06 ^2.07 ^2.08 ^2.09 ^2.10 ^2.11 ^2.12 ^2.13 ^2.14 Bourdon, JC et al. (2005) p53 isoforms can regulate p53 transcriptional activity. Genes Dev. 19 2122-37 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Radhakrishnan, VM et al. (2011) P53 suppresses expression of the 14-3-3 gamma oncogene. BMC Cancer 11 378 PubMed GONUTS page
↑ Tan, J et al. (2012) Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling. Chin. J. Cancer Res. 24 275-83 PubMed GONUTS page
↑ Son, DS et al. (2012) Inhibitory effect of tumor suppressor p53 on proinflammatory chemokine expression in ovarian cancer cells by reducing proteasomal degradation of IκB. PLoS ONE 7 e51116 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Jiang, Y et al. (2014) Rbm24, an RNA-binding protein and a target of p53, regulates p21 expression via mRNA stability. J. Biol. Chem. 289 3164-75 PubMed GONUTS page
↑ ^8.0 ^8.1 Austin, D et al. (2012) p53 Activation following Rift Valley fever virus infection contributes to cell death and viral production. PLoS ONE 7 e36327 PubMed GONUTS page
↑ ^9.0 ^9.1 Chen, X et al. (2010) G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis. J. Biol. Chem. 285 12823-30 PubMed GONUTS page
↑ ^10.0 ^10.1 Yasuda, K et al. (2012) Induction of apoptosis by cytoplasmically localized wild-type p53 and the S121F mutant super p53. Oncol Lett 3 978-982 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Budhram-Mahadeo, VS et al. (2006) Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Nucleic Acids Res. 34 6640-52 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Brázdová, M et al. (2013) Preferential binding of hot spot mutant p53 proteins to supercoiled DNA in vitro and in cells. PLoS ONE 8 e59567 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Toki, T et al. (2018) De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome. Am. J. Hum. Genet. 103 440-447 PubMed GONUTS page
↑ ^14.0 ^14.1 Hu, W et al. (2010) Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc. Natl. Acad. Sci. U.S.A. 107 7455-60 PubMed GONUTS page
↑ Xu-Monette, ZY et al. (2012) Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study. Blood 120 3986-96 PubMed GONUTS page
↑ Bonnefont, J et al. (2011) Primate-specific RFPL1 gene controls cell-cycle progression through cyclin B1/Cdc2 degradation. Cell Death Differ. 18 293-303 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Jansson, M et al. (2008) Arginine methylation regulates the p53 response. Nat. Cell Biol. 10 1431-9 PubMed GONUTS page
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