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PMID:21867493
| Citation |
Radhakrishnan, VM, Putnam, CW, Qi, W and Martinez, JD (2011) P53 suppresses expression of the 14-3-3 gamma oncogene. BMC Cancer 11:378 |
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| Abstract |
14-3-3 proteins are a family of highly conserved proteins that are involved in a wide range of cellular processes. Recent evidence indicates that some of these proteins have oncogenic activity and that they may promote tumorigenesis. We previously showed that one of the 14-3-3 family members, 14-3-3 gamma, is over expressed in human lung cancers and that it can induce transformation of rodent cells in vitro. |
| Links |
PubMed PMC3189929 Online version:10.1186/1471-2407-11-378 |
| Keywords |
14-3-3 Proteins/genetics; 14-3-3 Proteins/metabolism; Base Sequence; Binding Sites/genetics; Cell Line, Tumor; Colorectal Neoplasms/genetics; Colorectal Neoplasms/metabolism; Consensus Sequence; Gene Amplification; Gene Expression; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Mutation; Oncogenes; Promoter Regions, Genetic; RNA, Messenger; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/metabolism |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0000122: negative regulation of transcription from RNA polymerase II promoter |
ECO:0000315: |
P |
Figure 2C shows that 14-3-3gamma protein was suppressed when cells were infected with wt-p53-adenovirus. Figure 2D shows that expression of 14-3-3gamma protein was increased when p53 was suppressed. Figure 3 shows that p53 binds to 14-3-3gamma promoter region and negatively regulates transcription of 14-3-3gamma being expressed. |
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See also
References
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