PMID:15116721

Citation	Hofseth, LJ, Hussain, SP and Harris, CC (2004) p53: 25 years after its discovery. Trends Pharmacol. Sci. 25:177-81
Abstract	Since its discovery 25 years ago, the p53 protein has emerged as a key tumor suppressor protein at the crossroads of cellular stress response pathways. Through these pathways, which can lead to cell-cycle arrest, DNA repair, cellular senescence, differentiation and apoptosis, p53 facilitates the repair and survival of damaged cells or eliminates severely damaged cells from the replicative pool to protect the organism. Because of these dynamic and multiple functions of p53, which are largely lost following mutations in the gene encoding p53, this molecule continues to be studied intensively in biomedical research, including the fields of toxicology and pharmacology. In this article, we briefly review the first 25 years of research on p53.
Links	PubMed Online version:10.1016/j.tips.2004.02.009
Keywords	Apoptosis/physiology; DNA Repair; Humans; Research/trends; Tumor Suppressor Protein p53/genetics; Tumor Suppressor Protein p53/physiology
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:P53	involved_in	GO:0006284: base-excision repair	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:P53	involved_in	GO:0046902: regulation of mitochondrial membrane permeability	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:P53	involved_in	GO:0051262: protein tetramerization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete

References

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