PMID:10065150

Citation	Choi, J and Donehower, LA (1999) p53 in embryonic development: maintaining a fine balance. Cell. Mol. Life Sci. 55:38-47
Abstract	In addition to its role as a tumour suppressor and cell-cycle checkpoint control protein, p53 has been implicated as an important protein in embryonic development. Despite the viability of most p53 null mice, evidence has accumulated that p53 may regulate differentiation and the response of embryonic cells to diverse environmental stresses. Moreover, it appears that maintenance of a fine balance of p53 protein levels within embryonic cells is important for optimal development. Inappropriate overexpression or underexpression of p53 can lead to embryonic lethality or increased risk of malformations. The p53 protein may utilize multiple functional activities in its regulation of developmental processes.
Links	PubMed
Keywords	Animals; Animals, Genetically Modified; Cell Differentiation/genetics; Disease Models, Animal; Embryonic and Fetal Development; Gene Expression Regulation, Developmental/genetics; Mice; Mice, Knockout; Teratogens/metabolism; Tumor Suppressor Protein p53/genetics
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
HUMAN:P53	involved_in	GO:0007275: multicellular organism development	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
HUMAN:P53	involved_in	GO:0030154: cell differentiation	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
HUMAN:P53	involved_in	GO:0008283: cell population proliferation	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete

References

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