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HPV18:VE2
Contents
| Species (Taxon ID) | Human papillomavirus type 18. (333761) | |
| Gene Name(s) | E2 | |
| Protein Name(s) | Regulatory protein E2 | |
| External Links | ||
| UniProt | P06790 | |
| EMBL | X05015 | |
| PIR | D26251 | |
| PDB | 1F9F 1JJ4 1QQH 1TUE | |
| PDBsum | 1F9F 1JJ4 1QQH 1TUE | |
| ProteinModelPortal | P06790 | |
| SMR | P06790 | |
| IntAct | P06790 | |
| MINT | MINT-95532 | |
| EvolutionaryTrace | P06790 | |
| Proteomes | UP000009109 | |
| GO | GO:0042025 GO:0072686 GO:0003677 GO:0000166 GO:0003700 GO:0006260 GO:0039651 GO:0006275 GO:0006351 | |
| Gene3D | 2.170.200.10 3.30.70.330 | |
| InterPro | IPR012677 IPR000427 IPR001866 | |
| Pfam | PF00511 PF00508 | |
| ProDom | PD000672 | |
| SUPFAM | SSF51332 SSF54957 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0044163 |
host cytoskeleton |
ECO:0000314 |
C |
Figure 1D shows that E2 protein from HPV 18 binds to mitotic spindles and helps pull apart DNA strands as shown in the 3rd overlap of DNA, E2 and mitotic spindles. |
complete | |||||
| GO:0044191 |
host cell mitochondrial membrane |
ECO:0000314 |
C |
Figure 3: "HPV-18 E2 localizes to mitochondrial membranes" Regulatory protein E2 Human papillomavirus type 18 |
complete | |||||
| GO:0044193 |
host cell mitochondrial outer membrane |
ECO:0000314 |
C |
Mass spec analyses revealed association of E2 with outer mitochondrial membrane, as seen on FIG 2 and FIG 3. Regulatory protein E2 Human papillomavirus type 18 |
complete | |||||
|
part_of |
GO:0044163 |
host cytoskeleton |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006275 |
regulation of DNA replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000427 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006355 |
regulation of transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000427 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0016032 |
viral process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000242304 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003700 |
DNA-binding transcription factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000242304 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006351 |
transcription, DNA-templated |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000242304 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000242304 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0006275 |
regulation of DNA replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000242304 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000242304 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0039693 |
viral DNA genome replication |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
UniRule:UR000242304 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006260 |
DNA replication |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0042025 |
host cell nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 Van Tine, BA et al. (2004) Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning. Proc. Natl. Acad. Sci. U.S.A. 101 4030-5 PubMed GONUTS page
- ↑ 2.0 2.1 Lai, D et al. (2013) Localization of HPV-18 E2 at mitochondrial membranes induces ROS release and modulates host cell metabolism. PLoS ONE 8 e75625 PubMed GONUTS page
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