User:Mnbui2

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
acceptable	CHICK:GDPD5	2013-03-04 00:21:01 CST	GO:0045666 positive regulation of neuron differentiation (P)	PMID:23329048	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 1 (L to N). When GDE2 was overexpressed with Dll1 in chick spinal cords, GDE2's ability to induce neuron differentiation increased. This was shown by the increased Isl2+ motor neurons (red) in the presence of GDE2 and Dll1 compared to GDE2 by itself and Dll1 by itself.	challenge
acceptable	MOUSE:RIF1	2013-03-04 21:01:55 CST	GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining (P)	PMID:23306437	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2 The rate and incidence of telomere fusions decrease in cells in the absence of Rif1. In the presence of Rif1, nonhomologous end joining is promoted, which leads to double-stranded break repair.	challenge
acceptable	MOUSE:GDPD5	2013-03-15 01:18:06 CDT	GO:0045666 positive regulation of neuron differentiation (P)	PMID:23329048	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 1 (A to H). Lack of GDE2 in spinal cords of mice leads to a loss of spinal motor neurons (MN) and V0 interneurons.	challenge
acceptable	MOUSE:OX2G	2013-03-24 23:42:54 CDT	GO:0043031 negative regulation of macrophage activation (P)	PMID:11099416	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 2. Macrophage populations were activated in CD200-/- mice. This was observed in the increase of CD11b+ population and lymph node macrophages, and the change to a thick, multi-cell layer of MOMA-1+.	challenge
acceptable	MOUSE:MTOR	2013-03-25 11:22:38 CDT	GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process (P)	PMID:23429704	ECO:0000314 direct assay evidence used in manual assertion	Figure 2. HeLa cells exhibited a higher rate of de novo pyrimidine synthesis in the presence of growth factors and amino acids. It was then concluded that mTORC1 activates de novo pyrimidine synthesis.	challenge
acceptable	MOUSE:SPN90	2013-03-28 20:19:11 CDT	GO:0010976 positive regulation of neuron projection development (P)	PMID:21763308	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 6. When SPIN90 was knocked out, neurite outgrowth was inhibited. This was shown by comparing the length of the longest neurite and the length of shorter neurites of wild-type and of SPIN90 knocked-out hippocampal neurons.	challenge

acceptable:6
unacceptable:0
requires_changes:0
flagged:0

Annotations challenged by Mnbui2

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
updatedbyinstructor	Hayat Ahmed, Team Helicases	HUMAN:IL34	GO:0045657 - positive regulation of monocyte differentiation (P)	PMID:23409120	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2 fixed by Goodnoea
updatedbyinstructor	Alejandra Justo, Team Helicases	RAT:HXK3	GO:1901299 - negative regulation of hydrogen peroxide-mediated programmed cell death (P)	PMID:21072205	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2 fixed by Romero.alan
requireschanges	Dylandekalb, Team Higgs BROsons	MOUSE:SPN90	GO:0040008 - regulation of growth (P)	PMID:21763308	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 5
updatedbyinstructor	I.bargsley, Team Don't be anno-hating	HUMAN:NEK4	GO:0045893 - positive regulation of DNA-templated transcription (P)	PMID:22851694	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 4 fixed by I.bargsley
acceptable	Bennettv, Team Viral Load Challengers	PEDV7:VEMP	GO:0033664 - obsolete positive regulation by symbiont of host defense-related protein level (P)	PMID:23332027	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 3
acceptable	Ayusol, Team Viral Load Challengers	HUMAN:IFM1	GO:0046597 - host-mediated suppression of symbiont invasion (P)	PMID:23358889	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1

0 annotations fixed by Mnbui2

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