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HUMAN:IL34
Contents
| Species (Taxon ID) | Homo sapiens (Human). (9606) | |
| Gene Name(s) | IL34 (synonyms: C16orf77) | |
| Protein Name(s) | Interleukin-34
IL-34 | |
| External Links | ||
| UniProt | Q6ZMJ4 | |
| EMBL | EU599219 EU636994 AK172744 AK314913 AC020763 CH471241 BC029804 | |
| CCDS | CCDS10895.1 | |
| RefSeq | NP_001166242.1 NP_001166243.1 NP_689669.2 | |
| UniGene | Hs.461214 | |
| PDB | 4DKC 4DKD 4DKE 4DKF | |
| PDBsum | 4DKC 4DKD 4DKE 4DKF | |
| ProteinModelPortal | Q6ZMJ4 | |
| SMR | Q6ZMJ4 | |
| BioGrid | 126985 | |
| DIP | DIP-50037N | |
| IntAct | Q6ZMJ4 | |
| MINT | MINT-2878814 | |
| STRING | 9606.ENSP00000288098 | |
| DMDM | 74710540 | |
| PaxDb | Q6ZMJ4 | |
| PRIDE | Q6ZMJ4 | |
| Ensembl | ENST00000288098 ENST00000429149 | |
| GeneID | 146433 | |
| KEGG | hsa:146433 | |
| UCSC | uc002ezh.2 uc002ezi.2 | |
| CTD | 146433 | |
| GeneCards | GC16P070613 | |
| H-InvDB | HIX0013203 | |
| HGNC | HGNC:28529 | |
| HPA | HPA055971 | |
| MIM | 612081 | |
| neXtProt | NX_Q6ZMJ4 | |
| PharmGKB | PA162392024 | |
| eggNOG | NOG46280 | |
| GeneTree | ENSGT00390000000932 | |
| HOGENOM | HOG000113048 | |
| HOVERGEN | HBG108003 | |
| InParanoid | Q6ZMJ4 | |
| OMA | YKISVPY | |
| PhylomeDB | Q6ZMJ4 | |
| TreeFam | TF337386 | |
| GeneWiki | Interleukin_34 | |
| GenomeRNAi | 146433 | |
| NextBio | 85355 | |
| PRO | PR:Q6ZMJ4 | |
| Proteomes | UP000005640 | |
| Bgee | Q6ZMJ4 | |
| CleanEx | HS_IL34 | |
| ExpressionAtlas | Q6ZMJ4 | |
| Genevestigator | Q6ZMJ4 | |
| GO | GO:0005615 GO:0005157 GO:0006954 GO:0045087 GO:0008284 GO:0001934 | |
| InterPro | IPR020415 | |
| Pfam | PF15036 | |
| PRINTS | PR01938 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0045657 |
positive regulation of monocyte differentiation |
ECO:0000314 |
P |
Figure 1 |
complete | |||||
| GO:0045651 |
positive regulation of macrophage differentiation |
ECO:0000314 |
P |
Figure 2, A & B. IL-34 induces M2 cell differentiation to CD14 and CD163. |
complete | |||||
|
involved_in |
GO:0048714 |
positive regulation of oligodendrocyte differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045651 |
positive regulation of macrophage differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045657 |
positive regulation of monocyte differentiation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005157 |
macrophage colony-stimulating factor receptor binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0005125 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010469 |
regulation of signaling receptor activity |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008083 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0061518 |
microglial cell proliferation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R1R4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0048714 |
positive regulation of oligodendrocyte differentiation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R1R4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0010628 |
positive regulation of gene expression |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q8R1R4 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0001934 |
positive regulation of protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005157 |
macrophage colony-stimulating factor receptor binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
Reactome:R-HSA-449836 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005576 |
extracellular region |
Reactome:R-HSA-9009558 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
|
involved_in |
GO:0006954 |
inflammatory response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005125 |
cytokine activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615 |
extracellular space |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005576 |
extracellular region |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008083 |
growth factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Foucher, ED et al. (2013) IL-34 induces the differentiation of human monocytes into immunosuppressive macrophages. antagonistic effects of GM-CSF and IFNγ. PLoS ONE 8 e56045 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 Lin, H et al. (2008) Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 320 807-11 PubMed GONUTS page
- ↑ Ma, X et al. (2012) Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R. Structure 20 676-87 PubMed GONUTS page
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- GO:0045651 ! positive regulation of macrophage differentiation
- GO:0010628 ! positive regulation of gene expression
- GO:0001934 ! positive regulation of protein phosphorylation
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0048714 ! positive regulation of oligodendrocyte differentiation
- GO:0045657 ! positive regulation of monocyte differentiation
- Primates
