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HUMAN:NEK4

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) NEK4 (synonyms: STK2)
Protein Name(s) Serine/threonine-protein kinase Nek4

Never in mitosis A-related kinase 4 NimA-related protein kinase 4 Serine/threonine-protein kinase 2 Serine/threonine-protein kinase NRK2

External Links
UniProt P51957
EMBL L20321
EF560744
AK294165
AK312420
AC006254
AC104446
BC063044
CCDS CCDS2863.1
CCDS54593.1
PIR I78885
RefSeq NP_001180462.1
NP_003148.2
UniGene Hs.631921
ProteinModelPortal P51957
SMR P51957
BioGrid 112663
IntAct P51957
STRING 9606.ENSP00000233027
BindingDB P51957
ChEMBL CHEMBL5819
GuidetoPHARMACOLOGY 2119
PhosphoSite P51957
DMDM 229462924
MaxQB P51957
PaxDb P51957
PRIDE P51957
Ensembl ENST00000233027
ENST00000383721
ENST00000535191
GeneID 6787
KEGG hsa:6787
UCSC uc003dfq.4
uc003dfr.3
uc011bej.2
CTD 6787
GeneCards GC03M052744
H-InvDB HIX0030800
HGNC HGNC:11399
HPA HPA015750
MIM 601959
neXtProt NX_P51957
PharmGKB PA31548
eggNOG COG0515
GeneTree ENSGT00760000118997
HOGENOM HOG000294177
HOVERGEN HBG031740
InParanoid P51957
KO K08857
OMA SELESCW
OrthoDB EOG7D59P5
PhylomeDB P51957
TreeFam TF106472
SignaLink P51957
ChiTaRS NEK4
GenomeRNAi 6787
NextBio 26500
PMAP-CutDB P51957
PRO PR:P51957
Proteomes UP000005640
Bgee P51957
CleanEx HS_NEK4
ExpressionAtlas P51957
Genevestigator P51957
GO GO:0005737
GO:0005634
GO:0005524
GO:0030145
GO:0004674
GO:0006974
GO:0000278
GO:0007067
GO:0006468
GO:2000772
GO:1900062
InterPro IPR011009
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:1900062

regulation of replicative cell aging

PMID:22851694[1]

ECO:0000315

P

Figure 2

complete
CACAO 6082

GO:0045893

positive regulation of transcription, DNA-dependent

PMID:22851694[1]

ECO:0000315

P

Figure 4C shows that suppressed levels of NEK4 also suppress the amount of p21 mRNA.

complete
CACAO 6962

GO:2001020

regulation of response to DNA damage stimulus

PMID:22851694[1]

ECO:0000315

P

Figure 11

complete
CACAO 6963

involved_in

GO:1900062

regulation of replicative cell aging

PMID:22851694[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1J2

C

Seeded From UniProt

complete

enables

GO:0030145

manganese ion binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1J2

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1J2

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9Z1J2

P

Seeded From UniProt

complete

involved_in

GO:0000278

mitotic cell cycle

PMID:22851694[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:22851694[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1900062

regulation of replicative cell aging

PMID:22851694[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2000772

regulation of cellular senescence

PMID:22851694[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:2001020

regulation of response to DNA damage stimulus

PMID:22851694[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045893

positive regulation of transcription, DNA-templated

PMID:22851694[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032147

activation of protein kinase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1919399
PANTHER:PTN000684825
RGD:727905
UniProtKB:Q7RTN6
UniProtKB:Q9C0K7

P

Seeded From UniProt

complete

involved_in

GO:0031098

stress-activated protein kinase signaling cascade

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000684825
UniProtKB:A0A1D8PKE2
UniProtKB:A0A1D8PM87

P

Seeded From UniProt

complete

involved_in

GO:0023014

signal transduction by protein phosphorylation

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000684825
TAIR:locus:2205523
UniProtKB:Q9UEW8

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023083
FB:FBgn0025743
FB:FBgn0267698
MGI:MGI:1339975
MGI:MGI:1344404
MGI:MGI:1346867
MGI:MGI:1346875
MGI:MGI:1891638
MGI:MGI:1928487
MGI:MGI:1929004
PANTHER:PTN000684825
PomBase:SPAC1F3.02c
PomBase:SPBC17F3.02
PomBase:SPBC1D7.05
PomBase:SPBC409.07c
PomBase:SPBC543.07
RGD:3780
RGD:620966
RGD:621643
SGD:S000000999
SGD:S000002318
SGD:S000002931
SGD:S000003664
SGD:S000004354
SGD:S000005757
SGD:S000006061
TAIR:locus:2017662
TAIR:locus:2074835
TAIR:locus:2087130
TAIR:locus:2170578
UniProtKB:A0A0B4KGS4
UniProtKB:O00506
UniProtKB:O95819
UniProtKB:Q13043
UniProtKB:Q13153
UniProtKB:Q13177
UniProtKB:Q13188
UniProtKB:Q57Y61
UniProtKB:Q7RTN6
UniProtKB:Q8N4C8
UniProtKB:Q96PY6
UniProtKB:Q9C0K7
UniProtKB:Q9H2G2
UniProtKB:Q9P289
UniProtKB:Q9S7U9
UniProtKB:Q9UKE5
UniProtKB:Q9Y4K4
UniProtKB:Q9Y6E0
UniProtKB:Q9Y6R4
WB:WBGene00002177
WB:WBGene00002201
WB:WBGene00003368
WB:WBGene00013355
dictyBase:DDB_G0284181
dictyBase:DDB_G0286359

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0023083
FB:FBgn0025743
FB:FBgn0031030
FB:FBgn0035001
FB:FBgn0261456
FB:FBgn0267698
MGI:MGI:1344404
MGI:MGI:1346882
MGI:MGI:1349394
MGI:MGI:1355329
MGI:MGI:1858416
MGI:MGI:1917378
MGI:MGI:1920334
PANTHER:PTN000684825
PomBase:SPBC1604.14c
PomBase:SPBC21.06c
RGD:3250
RGD:3251
RGD:621643
RGD:708455
RGD:727905
SGD:S000005242
TAIR:locus:2035989
TAIR:locus:2045658
TAIR:locus:2080394
TAIR:locus:2116417
TAIR:locus:2133559
TAIR:locus:2174969
TAIR:locus:2205523
TAIR:locus:2206885
UniProtKB:A0A0B4KGS4
UniProtKB:C0H4N8
UniProtKB:O75914
UniProtKB:O94804
UniProtKB:O95747
UniProtKB:O95819
UniProtKB:O96013
UniProtKB:Q02750
UniProtKB:Q12851
UniProtKB:Q13043
UniProtKB:Q13153
UniProtKB:Q13177
UniProtKB:Q13188
UniProtKB:Q13233
UniProtKB:Q8IVH8
UniProtKB:Q8N4C8
UniProtKB:Q92918
UniProtKB:Q99558
UniProtKB:Q9H2G2
UniProtKB:Q9H2K8
UniProtKB:Q9UEW8
UniProtKB:Q9UKE5
UniProtKB:Q9UL54
UniProtKB:Q9Y4K4
UniProtKB:Q9Y6E0
WB:WBGene00013355
WB:WBGene00017472
dictyBase:DDB_G0276459
dictyBase:DDB_G0286359

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0097014

ciliary plasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZDV9
ensembl:ENSRNOP00000024296

C

Seeded From UniProt

complete

part_of

GO:0036064

ciliary basal body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZDV9
ensembl:ENSRNOP00000024296

C

Seeded From UniProt

complete

part_of

GO:0035869

ciliary transition zone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZDV9
ensembl:ENSRNOP00000024296

C

Seeded From UniProt

complete

part_of

GO:0035253

ciliary rootlet

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:D3ZDV9
ensembl:ENSRNOP00000024296

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:8208544[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:8208544[3]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0966

C

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0005929

cilium

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0066

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 Nguyen, CL et al. (2012) Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts. Mol. Cell. Biol. 32 3963-77 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 Levedakou, EN et al. (1994) Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern. Oncogene 9 1977-88 PubMed GONUTS page
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