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HUMAN:IFM1

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) IFITM1 (synonyms: CD225, IFI17)
Protein Name(s) Interferon-induced transmembrane protein 1

Dispanin subfamily A member 2a DSPA2a Interferon-induced protein 17 Interferon-inducible protein 9-27 Leu-13 antigen

External Links
UniProt P13164
EMBL J04164
X84958
BT007173
AK290480
AC136475
CH471278
BC000897
CCDS CCDS41584.1
PIR A31454
RefSeq NP_003632.3
UniGene Hs.458414
ProteinModelPortal P13164
BioGrid 114091
DIP DIP-32672N
IntAct P13164
MINT MINT-1036538
STRING 9606.ENSP00000386187
PhosphoSite P13164
DMDM 215274118
MaxQB P13164
PaxDb P13164
PeptideAtlas P13164
PRIDE P13164
DNASU 8519
Ensembl ENST00000328221
ENST00000408968
ENST00000528780
GeneID 8519
KEGG hsa:8519
UCSC uc001loy.4
CTD 8519
GeneCards GC11P000313
HGNC HGNC:5412
HPA CAB017615
HPA004810
MIM 604456
neXtProt NX_P13164
PharmGKB PA29653
eggNOG NOG268489
GeneTree ENSGT00390000003476
HOGENOM HOG000115781
HOVERGEN HBG001182
InParanoid P13164
KO K06566
OMA WCCLGFI
OrthoDB EOG7288T5
PhylomeDB P13164
TreeFam TF334894
Reactome REACT_11152
REACT_25162
ChiTaRS IFITM1
GeneWiki IFITM1
GenomeRNAi 8519
NextBio 31894
PRO PR:P13164
Proteomes UP000005640
Bgee P13164
CleanEx HS_IFITM1
Genevestigator P13164
GO GO:0016021
GO:0016020
GO:0005886
GO:0005057
GO:0007166
GO:0019221
GO:0051607
GO:0035556
GO:0030336
GO:0008285
GO:0046597
GO:0045071
GO:0001503
GO:0045669
GO:0050776
GO:0035455
GO:0035456
GO:0034341
GO:0009615
GO:0060337
InterPro IPR007593
Pfam PF04505

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0046597

regulation of defense response to virus by host

PMID:23358889[1]

ECO:0000314

P

Figues 1, particularly B, and 3 indicate that IFITM1 protein acts as a defense mechanism against viral membrane fusion.

complete
CACAO 6529

GO:0046597

negative regulation of viral entry into host cell

PMID:23358889[1]

ECO:0000314

P

Figure 1 IFITM proteins differentially restrict JSRV, 10A1 MLV, IAV and VSV entry and Figure 4 Cell-cell fusion induced by JSRV Env is inhibited by IFITM proteins, and extracellular low pH pulse cannot overcome IFITM1-mediated restriction on JSRV entry clearly show that IFITM1 is acting as a defense by redistricting the virus from entering the host.

complete
CACAO 6575

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:23358889[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

PMID:19946888[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045669

positive regulation of osteoblast differentiation

PMID:22634173[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:21976647[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035456

response to interferon-beta

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035455

response to interferon-alpha

PMID:22479637[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034341

response to interferon-gamma

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030336

negative regulation of cell migration

PMID:20838853[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:21253575[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

PMID:22479637[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:20838853[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
PANTHER:PTN000360680

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
MGI:MGI:1915963
MGI:MGI:1933382
PANTHER:PTN000360680
UniProtKB:Q01628

P

Seeded From UniProt

complete

involved_in

GO:0046597

negative regulation of viral entry into host cell

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
MGI:MGI:1915963
MGI:MGI:1933382
PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0045071

negative regulation of viral genome replication

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0035456

response to interferon-beta

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0035455

response to interferon-alpha

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

involved_in

GO:0034341

response to interferon-gamma

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000360680
UniProtKB:P13164
UniProtKB:Q01628
UniProtKB:Q01629

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:21873635[8]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1913391
MGI:MGI:1934923
PANTHER:PTN000360661
RGD:1307900
UniProtKB:Q01628

C

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:28246125[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR007593

C

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

PMID:7559564[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

PMID:7559564[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:7559564[10]
Reactome:R-HSA-199518
Reactome:R-HSA-1015702

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

involved_in

GO:0060337

type I interferon signaling pathway

Reactome:R-HSA-909733

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050776

regulation of immune response

Reactome:R-HSA-198933

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0001503

ossification

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0892

P

Seeded From UniProt

complete

involved_in

GO:0051607

defense response to virus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0051

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1003
UniProtKB-SubCell:SL-0039

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 Li, K et al. (2013) IFITM proteins restrict viral membrane hemifusion. PLoS Pathog. 9 e1003124 PubMed GONUTS page
  2. ↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Huang, IC et al. (2011) Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 7 e1001258 PubMed GONUTS page
  4. ↑ Kim, BS et al. (2012) IFITM1 increases osteogenesis through Runx2 in human alveolar-derived bone marrow stromal cells. Bone 51 506-14 PubMed GONUTS page
  5. ↑ Raychoudhuri, A et al. (2011) ISG56 and IFITM1 proteins inhibit hepatitis C virus replication. J. Virol. 85 12881-9 PubMed GONUTS page
  6. ↑ 6.0 6.1 Chan, YK et al. (2012) IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE 7 e34508 PubMed GONUTS page
  7. ↑ 7.0 7.1 Yu, F et al. (2011) Knockdown of interferon-induced transmembrane protein 1 (IFITM1) inhibits proliferation, migration, and invasion of glioma cells. J. Neurooncol. 103 187-95 PubMed GONUTS page
  8. ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  9. ↑ Fu, B et al. (2017) ZMPSTE24 defends against influenza and other pathogenic viruses. J. Exp. Med. 214 919-929 PubMed GONUTS page
  10. ↑ 10.0 10.1 10.2 Deblandre, GA et al. (1995) Expression cloning of an interferon-inducible 17-kDa membrane protein implicated in the control of cell growth. J. Biol. Chem. 270 23860-6 PubMed GONUTS page
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