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PMID:22479637

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Citation

Chan, YK, Huang, IC and Farzan, M (2012) IFITM proteins restrict antibody-dependent enhancement of dengue virus infection. PLoS ONE 7:e34508

Abstract

Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via antibody-dependent enhancement (ADE) in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediated DENV infection bypasses IFITM-mediated restriction or whether IFITM proteins can be protective in a secondary infection. We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections.

Links

PubMed PMC3316688 Online version:10.1371/journal.pone.0034508

Keywords

Animals; Antibody-Dependent Enhancement; Cell Line; Cell Line, Tumor; Dengue/immunology; Dengue/virology; Dengue Virus/immunology; Humans; Interferons/immunology; Membrane Proteins/immunology; Mice

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:IFM1

involved_in

GO:0009615: response to virus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IFM1

involved_in

GO:0035455: response to interferon-alpha

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IFM2

involved_in

GO:0035455: response to interferon-alpha

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IFM2

involved_in

GO:0009615: response to virus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IFM3

involved_in

GO:0009615: response to virus

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

HUMAN:IFM3

involved_in

GO:0035455: response to interferon-alpha

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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