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PMID:21072205
| Citation |
Wyatt, E, Wu, R, Rabeh, W, Park, HW, Ghanefar, M and Ardehali, H (2010) Regulation and cytoprotective role of hexokinase III. PLoS ONE 5:e13823 |
|---|---|
| Abstract |
Hexokinases (HKs) catalyze the first step in glucose metabolism. Of the three mammalian 100-kDa HK isoforms, HKI and II can bind to mitochondria and protect against cell death. HKIII does not bind mitochondria, and little is known about its regulation or cytoprotective effects. We studied the regulation of HKIII at the transcriptional and protein levels and investigated its role in cellular protection. |
| Links |
PubMed PMC2972215 Online version:10.1371/journal.pone.0013823 |
| Keywords |
Adenosine Triphosphate/metabolism; Animals; Blotting, Western; Catalytic Domain/genetics; Cell Hypoxia; Cell Line, Tumor; Cell Survival/drug effects; Cytoprotection/genetics; Gene Expression Regulation, Enzymologic; Green Fluorescent Proteins/genetics; Green Fluorescent Proteins/metabolism; HEK293 Cells; Hexokinase/genetics; Hexokinase/metabolism; Humans; Hydrogen Peroxide/pharmacology; Hypoxia-Inducible Factor 1/genetics; Hypoxia-Inducible Factor 1/metabolism; Isoenzymes/genetics; Isoenzymes/metabolism; Membrane Potential, Mitochondrial/physiology; Microscopy, Confocal; Mutation; Oxidants/pharmacology; Reactive Oxygen Species/metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction/physiology; Transfection |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:1901299: negative regulation of hydrogen peroxide-mediated programmed cell death |
ECO:0000314: |
P |
Figure 4 (B and C) |
complete | ||||
|
involved_in |
GO:1901299: negative regulation of hydrogen peroxide-mediated programmed cell death |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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