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RAT:HXK3

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Species (Taxon ID) Rattus norvegicus (Rat). (10116)
Gene Name(s) Hk3
Protein Name(s) Hexokinase-3

Hexokinase type III HK III

External Links
UniProt P27926
EMBL U73859
BC100648
PIR S13913
RefSeq NP_071515.1
XP_006253664.1
XP_006253665.1
XP_008769706.1
UniGene Rn.162179
ProteinModelPortal P27926
SMR P27926
BioGrid 247137
STRING 10116.ENSRNOP00000031587
ChEMBL CHEMBL3632
PhosphoSite P27926
PaxDb P27926
PRIDE P27926
Ensembl ENSRNOT00000031935
GeneID 25060
KEGG rno:25060
UCSC RGD:2798
CTD 3101
RGD 2798
eggNOG COG5026
GeneTree ENSGT00390000017159
HOGENOM HOG000162671
HOVERGEN HBG005020
InParanoid P27926
KO K00844
OrthoDB EOG7S21X5
PhylomeDB P27926
TreeFam TF314238
Reactome REACT_205960
SABIO-RK P27926
UniPathway UPA00242
NextBio 605280
Proteomes UP000002494
Genevestigator P27926
GO GO:0005829
GO:0005739
GO:0043234
GO:0005524
GO:0019899
GO:0008865
GO:0004340
GO:0004396
GO:0042562
GO:0019158
GO:0046835
GO:0001678
GO:0051156
GO:0006096
GO:0019318
InterPro IPR001312
IPR022673
IPR019807
IPR022672
PANTHER PTHR19443
Pfam PF00349
PF03727
PRINTS PR00475
PROSITE PS00378

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:1901299

negative regulation of hydrogen peroxide-mediated programmed cell death

PMID:21072205[1]

ECO:0000314

P

Figure 4 (B and C)

complete
CACAO 6680

involved_in

GO:1901299

negative regulation of hydrogen peroxide-mediated programmed cell death

PMID:21072205[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042562

hormone binding

PMID:11068878[2]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:69123

F

Seeded From UniProt

complete

part_of

GO:0032991

protein-containing complex

PMID:11068878[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0019899

enzyme binding

PMID:11068878[2]

ECO:0000353

physical interaction evidence used in manual assertion

RGD:737496

F

Seeded From UniProt

complete

involved_in

GO:0008150

biological_process

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004396

hexokinase activity

PMID:15138155[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0019158

mannokinase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000455350
PomBase:SPAC24H6.04
PomBase:SPAC4F8.07c

F

Seeded From UniProt

complete

enables

GO:0008865

fructokinase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000455350
PomBase:SPAC24H6.04
PomBase:SPAC4F8.07c
TAIR:locus:2008031
TAIR:locus:2087590
TAIR:locus:2119931
TAIR:locus:2137564
TAIR:locus:2202410
UniProtKB:P93834
UniProtKB:Q4WHC3

F

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000455350
RGD:2670
RGD:2796
SGD:S000000545
SGD:S000001949
SGD:S000003222

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1270854
MGI:MGI:96103
PANTHER:PTN000455350
RGD:2670
RGD:2796
SGD:S000003222
UniProtKB:C6KT76
UniProtKB:P35557

C

Seeded From UniProt

complete

enables

GO:0004340

glucokinase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1270854
MGI:MGI:96103
PANTHER:PTN000455350
PomBase:SPAC24H6.04
PomBase:SPAC4F8.07c
RGD:2670
RGD:2796
SGD:S000000545
TAIR:locus:2008031
TAIR:locus:2087590
TAIR:locus:2119931
TAIR:locus:2137564
TAIR:locus:2202410
UniProtKB:P35557
UniProtKB:P93834
UniProtKB:Q4WCS2
UniProtKB:Q4WHC3
UniProtKB:Q5W676
UniProtKB:Q8LQ68

F

Seeded From UniProt

complete

involved_in

GO:0001678

cellular glucose homeostasis

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1270854
PANTHER:PTN000455350
RGD:2670

P

Seeded From UniProt

complete

involved_in

GO:0046835

carbohydrate phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004396

P

Seeded From UniProt

complete

involved_in

GO:0046835

carbohydrate phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004396

P

Seeded From UniProt

complete

involved_in

GO:0046835

carbohydrate phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0019158

P

Seeded From UniProt

complete

involved_in

GO:0046835

carbohydrate phosphorylation

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0008865

P

Seeded From UniProt

complete

involved_in

GO:0046835

carbohydrate phosphorylation

GO_REF:0000108

ECO:0000366

evidence based on logical inference from automatic annotation used in automatic assertion

GO:0004396

P

Seeded From UniProt

complete

involved_in

GO:0051156

glucose 6-phosphate metabolic process

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004340

P

Seeded From UniProt

complete

involved_in

GO:0001678

cellular glucose homeostasis

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001312

P

Seeded From UniProt

complete

enables

GO:0004396

hexokinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001312
InterPro:IPR019807

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001312
InterPro:IPR019807
InterPro:IPR022672
InterPro:IPR022673

F

Seeded From UniProt

complete

enables

GO:0005536

glucose binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001312

F

Seeded From UniProt

complete

involved_in

GO:0005975

carbohydrate metabolic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR001312
InterPro:IPR022672
InterPro:IPR022673

P

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019807

P

Seeded From UniProt

complete

enables

GO:0016773

phosphotransferase activity, alcohol group as acceptor

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR022672
InterPro:IPR022673

F

Seeded From UniProt

complete

enables

GO:0004396

hexokinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.1.1

F

Seeded From UniProt

complete

involved_in

GO:0008152

metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

P

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0006096

glycolytic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0324

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0003824

catalytic activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0021

F

Seeded From UniProt

complete

involved_in

GO:0019318

hexose metabolic process

GO_REF:0000041

ECO:0000322

imported manually asserted information used in automatic assertion

UniPathway:UPA00242

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Wyatt, E et al. (2010) Regulation and cytoprotective role of hexokinase III. PLoS ONE 5 e13823 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Sui, D & Wilson, JE (2000) Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase. Arch. Biochem. Biophys. 382 262-74 PubMed GONUTS page
  3. ↑ Fujimoto, Y et al. (2004) Defect in glucokinase translocation in Zucker diabetic fatty rats. Am. J. Physiol. Endocrinol. Metab. 287 E414-23 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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