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MOUSE:SPN90

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Nckipsd (synonyms: Spin90, Wasbp)
Protein Name(s) NCK-interacting protein with SH3 domain

54 kDa VacA-interacting protein VIP54 90 kDa N-WASP-interacting protein 90 kDa SH3 protein interacting with Nck SH3 adapter protein SPIN90 WASP-interacting SH3-domain protein WISH Wiskott-Aldrich syndrome protein-binding protein N-WASP-binding protein

External Links
UniProt Q9ESJ4
EMBL AF130313
AK134725
CH466560
BC064818
CCDS CCDS23538.1
RefSeq NP_109654.2
UniGene Mm.192416
ProteinModelPortal Q9ESJ4
SMR Q9ESJ4
BioGrid 219860
IntAct Q9ESJ4
MINT MINT-157148
PhosphoSite Q9ESJ4
MaxQB Q9ESJ4
PaxDb Q9ESJ4
PRIDE Q9ESJ4
Ensembl ENSMUST00000035218
GeneID 80987
KEGG mmu:80987
UCSC uc009rqz.1
CTD 51517
MGI MGI:1931834
eggNOG NOG283973
GeneTree ENSGT00390000015725
HOGENOM HOG000008184
HOVERGEN HBG061630
InParanoid Q9ESJ4
OMA PATSSIM
OrthoDB EOG7966G7
PhylomeDB Q9ESJ4
TreeFam TF324522
Reactome REACT_198374
NextBio 350330
PRO PR:Q9ESJ4
Proteomes UP000000589
Bgee Q9ESJ4
CleanEx MM_NCKIPSD
Genevestigator Q9ESJ4
GO GO:0008180
InterPro IPR018556
IPR001452
Pfam PF09431
PF00018
SMART SM00326
SUPFAM SSF50044
PROSITE PS50002

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0040008

regulation of growth

PMID:21763308[1]

ECO:0000315

P

Figure 4 - SPIN90 affects cytoskeleton organization by "regulating growth cone morphology"

complete
CACAO 6621

involved_in

GO:0010976

positive regulation of neuron projection development

PMID:21763308[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

GO:0010976

positive regulation of neuron projection development

PMID:21763308[1]

ECO:0000315

P

Figure 6. When SPIN90 was knocked out, neurite outgrowth was inhibited. This was shown by comparing the length of the longest neurite and the length of shorter neurites of wild-type and of SPIN90 knocked-out hippocampal neurons.

complete
CACAO 7158

colocalizes_with

GO:0008180

COP9 signalosome

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q9NZQ3

C

Seeded From UniProt

complete

part_of

GO:0008180

COP9 signalosome

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9NZQ3
ensembl:ENSP00000294129

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0017124

SH3 domain binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0729

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Kim, SM et al. (2011) Control of growth cone motility and neurite outgrowth by SPIN90. Exp. Cell Res. 317 2276-87 PubMed GONUTS page