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User:Bennettv

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My Annotations

StatusPageDate/TimeGO Term (Aspect)ReferenceEvidenceNotesLinks
acceptableCXB3N:POLG2013-02-03 22:42:55 CSTGO:0042025 host cell nucleus (C)PMID:23010168ECO:0000314 direct assay evidence used in manual assertion

Fig. 1 shows the nuclear localization of this protein

challenge
acceptableCXB3N:POLG2013-02-03 22:52:55 CSTGO:0042025 host cell nucleus (C)PMID:23010168ECO:0000315 mutant phenotype evidence used in manual assertion

Fig. 4 shows the effects of mutation of the nuclear localization signal

challenge
acceptableHHV1:Q3MU882013-02-05 00:35:37 CSTGO:0046823 negative regulation of nucleocytoplasmic transport (P)PMID:22334672ECO:0000314 direct assay evidence used in manual assertion

Figure 8 demonstrates the way that this protein is able to block NLS and M9-mediated nucleocytoplasmic transport pathways in the host

challenge
acceptableHHV1:Q3MU882013-02-05 00:43:45 CSTGO:0042025 host cell nucleus (C)PMID:22334672ECO:0000315 mutant phenotype evidence used in manual assertion

Fig. 9 shows the effects that different mutations have on the protein's ability to localize to the nucleus

challenge
acceptableEBVB9:KR22013-03-03 22:51:07 CSTGO:0042025 host cell nucleus (C)PMID:22623767ECO:0000315 mutant phenotype evidence used in manual assertion

Figure 2 demonstrates that deletions of the N- and C-terminal regions of this protein inhibit its ability to localize to the host nucleus

challenge
acceptableEBVB9:KR22013-03-04 20:48:18 CSTGO:0044199 host cell nuclear envelope (C)PMID:22623767ECO:0000314 direct assay evidence used in manual assertion

Fig. 6 shows the association of the C terminus of this protein with the host nuclear envelope

challenge
updatedbyinstructorPEDV7:VEMP2013-03-04 21:05:47 CSTGO:0044165 host cell endoplasmic reticulum (C)PMID:23332027ECO:0000314 direct assay evidence used in manual assertion

Figure 1C shows that the majority of this protein localizes to the host ER.

challenge
updatedbyinstructorPEDV7:VEMP2013-03-04 21:08:16 CSTGO:0042025 host cell nucleus (C)PMID:23332027ECO:0000314 direct assay evidence used in manual assertion

Figure 1C shows that while the majority of this protein localizes to the host ER, a small amount localizes to the host nucleus.

challenge
acceptablePEDV7:VEMP2013-03-04 21:18:42 CSTGO:0033664 positive regulation by symbiont of host defense-related protein level (P)PMID:23332027ECO:0000314 direct assay evidence used in manual assertion

Fig. 5 shows that this protein increases the expression of interleukin-8 in host cells.

challenge

acceptable:7
unacceptable:0
requires_changes:0
flagged:0

Annotations challenged by Bennettv

StatusAuthor,GroupPageGO Term (Aspect)ReferenceEvidenceLinksPage history
unacceptableSbutler,
Team Thundercats Ho!
HUMAN:KSYKGO:0004672 - protein kinase activity (F)PMID:18369315ECO:0000314 direct assay evidence used in manual assertionchallengeC: 4
requireschangesMcalisterj,
Team Legend (wait for it) DARY
HHV1F:GBGO:0055036 - virion membrane (C)PMID:255182ECO:0000314 direct assay evidence used in manual assertionchallengeC: 1
updatedbyinstructorJtplaisted,
Team The Terminators
CAEEL:PMK1GO:0004707 - MAP kinase activity (F)PMID:16166371ECO:0000314 direct assay evidence used in manual assertionchallengeC: 4
updatedbyinstructorPungo,
Team The Terminators
CAEEL:AKT1GO:0042771 - intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (P)PMID:17276923ECO:0000315 mutant phenotype evidence used in manual assertionchallengeC: 2

0 annotations fixed by Bennettv

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