CXB3N:POLG

Species (Taxon ID)	Coxsackievirus B3 (strain Nancy). (103903)
Gene Name(s)	No Information Provided.
Protein Name(s)	Genome polyprotein P3 Protein 3AB P2 P1 Capsid protein VP0 VP4-VP2 Capsid protein VP4 P1A Virion protein 4 Capsid protein VP2 P1B Virion protein 2 Capsid protein VP3 P1C Virion protein 3 Capsid protein VP1 P1D Virion protein 1 Protease 2A P2A Picornain 2A Protein 2A Protein 2B P2B Protein 2C P2C Protein 3A P3A Viral protein genome-linked VPg Protein 3B P3B Protein 3CD Protease 3C P3C RNA-directed RNA polymerase RdRp 3D polymerase 3Dpol Protein 3D 3D
External Links
UniProt	P03313
EMBL	M33854 K02709 M16572
PIR	A26354 A34664
PDB	2VB0 2ZTX 2ZTY 2ZTZ 2ZU1 2ZU3 3CDU 3CDW 4WFX 4WFY 4WFZ
PDBsum	2VB0 2ZTX 2ZTY 2ZTZ 2ZU1 2ZU3 3CDU 3CDW 4WFX 4WFY 4WFZ
ProteinModelPortal	P03313
SMR	P03313
BindingDB	P03313
ChEMBL	CHEMBL2396505
MEROPS	C03.020
EvolutionaryTrace	P03313
Proteomes	UP000007760
GO	GO:0044162 GO:0042025 GO:0044385 GO:0016020 GO:0039618 GO:0005524 GO:0004197 GO:0005216 GO:0003723 GO:0003724 GO:0003968 GO:0005198 GO:0006260 GO:0075509 GO:0039520 GO:0039707 GO:0044694 GO:0051259 GO:0018144 GO:0039657 GO:0039522 GO:0039544 GO:0039611 GO:0006351 GO:0039694 GO:0019062
Gene3D	2.60.120.20 4.10.80.10
InterPro	IPR003593 IPR000605 IPR014759 IPR027417 IPR014838 IPR000081 IPR000199 IPR003138 IPR002527 IPR001676 IPR001205 IPR007094 IPR009003 IPR029053
Pfam	PF08727 PF00548 PF02226 PF00947 PF01552 PF00680 PF00073 PF00910
ProDom	PD001306 PD649346
SMART	SM00382
SUPFAM	SSF50494 SSF52540 SSF89043
PROSITE	PS50507 PS51218

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042025	host cell nucleus	PMID:23010168^[1]	ECO:0000314			C		Fig. 1 shows the nuclear localization of this protein	complete CACAO 6334
	GO:0042025	host cell nucleus	PMID:23010168^[1]	ECO:0000315			C		Fig. 4 shows the effects of mutation of the nuclear localization signal	complete CACAO 6335
involved_in	GO:0044832	positive regulation by virus of host cytokine production	PMID:25219837^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P10749)\|has_regulation_target:(UniProtKB:P08505)	Seeded From UniProt	complete
involved_in	GO:0061765	modulation by virus of host NIK/NF-kappaB signaling	PMID:25219837^[2]	ECO:0000305	curator inference used in manual assertion	GO:0044832	P		Seeded From UniProt	complete
involved_in	GO:0061765	modulation by virus of host NIK/NF-kappaB signaling	PMID:26764146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0039656	modulation by virus of host gene expression	PMID:26764146^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000028842) occurs_in:(UBERON:0000948) occurs_in:(UBERON:0007023)\|regulates_expression_of(ENSEMBL:ENSMUSG00000028842) occurs_in:(CL:0000746) occurs_in:(UBERON:0007221) regulates:(GO:0035195)\|regulates:_expression_of(ENSEMBL:ENSMUSG00000041530) occurs_in:(UBERON:0000948) occurs_in:(UBERON:0007023)\|regulates_expression_of(ENSEMBL:ENSMUSG00000041530) occurs_in:(CL:0000746) occurs_in:(UBERON:0007221) regulates:(GO:0035195)\|regulates:_expression_of(ENSEMBL:ENSMUSG00000024927)	Seeded From UniProt	complete
involved_in	GO:0039656	modulation by virus of host gene expression	PMID:26931072^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_expression_of:(ENSEMBL:ENSMUSG00000065397) occurs_in:(CL:0000235)	Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	PMID:23010168^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0042025	host cell nucleus	PMID:23010168^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0039520	induction by virus of host autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03300	P		Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P		Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P		Seeded From UniProt	complete
involved_in	GO:0001172	transcription, RNA-templated	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0003968	P		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005216	P		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000605 InterPro:IPR001205	F		Seeded From UniProt	complete
enables	GO:0003724	RNA helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000605	F		Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001205 InterPro:IPR007094 InterPro:IPR014838	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000199 InterPro:IPR014838	F		Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001676 InterPro:IPR003138	F		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001205	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000081 InterPro:IPR000199	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000081	F		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000081	P		Seeded From UniProt	complete
enables	GO:0017111	nucleoside-triphosphatase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014838	F		Seeded From UniProt	complete
part_of	GO:0019028	viral capsid	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001676 InterPro:IPR003138	C		Seeded From UniProt	complete
involved_in	GO:0039694	viral RNA genome replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR007094	P		Seeded From UniProt	complete
enables	GO:0017111	nucleoside-triphosphatase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.6.1.15	F		Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.7.48	F		Seeded From UniProt	complete
involved_in	GO:0039611	suppression by virus of host translation initiation factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03305:PRO_0000039873	P		Seeded From UniProt	complete
involved_in	GO:0039522	suppression by virus of host mRNA export from nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03300:PRO_0000040084	P		Seeded From UniProt	complete
involved_in	GO:0039690	positive stranded viral RNA replication	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P03300:PRO_0000040090	P		Seeded From UniProt	complete
involved_in	GO:0039657	suppression by virus of host gene expression	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1190	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0019028	viral capsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0167	C		Seeded From UniProt	complete
part_of	GO:0030430	host cell cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1035 UniProtKB-SubCell:SL-0381	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0039503	suppression by virus of host innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1090	P		Seeded From UniProt	complete
enables	GO:0016779	nucleotidyltransferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0548	F		Seeded From UniProt	complete
involved_in	GO:0018144	RNA-protein covalent cross-linking	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0191	P		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0235	P		Seeded From UniProt	complete
involved_in	GO:0030683	evasion or tolerance by virus of host immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0899	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0044161	host cell cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1036	C		Seeded From UniProt	complete
part_of	GO:0019012	virion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0946 UniProtKB-SubCell:SL-0274	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0044694	pore-mediated entry of viral genome into host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1172	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
part_of	GO:0039618	T=pseudo3 icosahedral viral capsid	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1143	C		Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F		Seeded From UniProt	complete
involved_in	GO:0039540	suppression by virus of host RIG-I activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1088	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0019062	virion attachment to host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1161	P		Seeded From UniProt	complete
involved_in	GO:0039707	pore formation by virus in membrane of host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1182	P		Seeded From UniProt	complete
involved_in	GO:0046718	viral entry into host cell	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1162 UniProtKB-KW:KW-1160	P		Seeded From UniProt	complete
involved_in	GO:0039520	induction by virus of host autophagy	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1072	P		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1182	F		Seeded From UniProt	complete
involved_in	GO:0075509	endocytosis involved in viral entry into host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1164	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
part_of	GO:0044385	integral to membrane of host cell	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1182	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0039522	suppression by virus of host mRNA export from nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1099	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0003968	RNA-directed 5'-3' RNA polymerase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0696	F		Seeded From UniProt	complete
part_of	GO:0033644	host cell membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1043	C		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1182	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0044162	host cell cytoplasmic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0387	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Wang, T et al. (2012) A functional nuclear localization sequence in the VP1 capsid protein of coxsackievirus B3. Virology 433 513-21 PubMed GONUTS page
↑ ^2.0 ^2.1 Bao, JL & Lin, L (2014) MiR-155 and miR-148a reduce cardiac injury by inhibiting NF-κB pathway during acute viral myocarditis. Eur Rev Med Pharmacol Sci 18 2349-56 PubMed GONUTS page
↑ ^3.0 ^3.1 Sun, S et al. () Argonaute proteins in cardiac tissue contribute to the heart injury during viral myocarditis. Cardiovasc. Pathol. 25 120-6 PubMed GONUTS page
↑ Zhang, Y et al. (2016) Silencing MicroRNA-155 Attenuates Cardiac Injury and Dysfunction in Viral Myocarditis via Promotion of M2 Phenotype Polarization of Macrophages. Sci Rep 6 22613 PubMed GONUTS page

[PMID:23010168-1] 1.0 ^1.1 ^1.2 ^1.3 Wang, T et al. (2012) A functional nuclear localization sequence in the VP1 capsid protein of coxsackievirus B3. Virology 433 513-21 PubMed GONUTS page

[PMID:25219837-2] 2.0 ^2.1 Bao, JL & Lin, L (2014) MiR-155 and miR-148a reduce cardiac injury by inhibiting NF-κB pathway during acute viral myocarditis. Eur Rev Med Pharmacol Sci 18 2349-56 PubMed GONUTS page

[PMID:26764146-3] 3.0 ^3.1 Sun, S et al. () Argonaute proteins in cardiac tissue contribute to the heart injury during viral myocarditis. Cardiovasc. Pathol. 25 120-6 PubMed GONUTS page

[PMID:26931072-4] Zhang, Y et al. (2016) Silencing MicroRNA-155 Attenuates Cardiac Injury and Dysfunction in Viral Myocarditis via Promotion of M2 Phenotype Polarization of Macrophages. Sci Rep 6 22613 PubMed GONUTS page

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CXB3N:POLG

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