Category:GO:0035195 ! miRNA-mediated post-transcriptional gene silencing

name: miRNA-mediated post-transcriptional gene silencing
namespace: biological_process
def: "A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants." [GOC:aruk, GOC:bc, GOC:rl, PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154, PMID:23985560, PMID:28379604]
synonym: "gene silencing by microRNA" EXACT [GOC:pr]
synonym: "gene silencing by miRNA" EXACT [GOC:dph, GOC:tb]
synonym: "microRNA-mediated gene silencing" EXACT []
synonym: "miRNA-mediated gene silencing" BROAD []
is_a: GO:0035194 ! regulatory ncRNA-mediated post-transcriptional gene silencing

AmiGO <GOterm>GO:0035195</GOterm>
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