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Category:GO:0035279 ! miRNA-mediated gene silencing by mRNA destabilization
name: miRNA-mediated gene silencing by mRNA destabilization
namespace: biological_process
def: "An RNA interference pathway in which microRNAs (miRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), a miRNA base pairing with near-perfect complementarity to the target mRNA will typically direct targeted endonucleolytic cleavage of the mRNA. Many plant miRNAs downregulate gene expression through this mechanism." [GOC:dph, GOC:mtg_lung, PMID:14744438, PMID:15196554, PMID:21118121, PMID:23209154]
synonym: "deadenylation involved in gene silencing by miRNA" RELATED []
synonym: "gene silencing by miRNA, mRNA cleavage" EXACT [GOC:mah]
synonym: "gene silencing by mRNA cleavage" BROAD []
synonym: "miRNA-mediated gene silencing by mRNA deadenylation" RELATED []
synonym: "miRNA-mediated gene silencing, mRNA cleavage" EXACT [GOC:dph, GOC:tb]
synonym: "mRNA cleavage involved in gene silencing by microRNA" EXACT [GOC:pr]
synonym: "mRNA cleavage involved in gene silencing by miRNA" EXACT []
synonym: "mRNA deadenylation-mediated gene silencing by miRNA" RELATED []
synonym: "mRNA destabilization-mediated gene silencing by miRNA" EXACT []
is_a: GO:0035195 ! miRNA-mediated post-transcriptional gene silencing
is_a: GO:0061157 ! mRNA destabilization
AmiGO
<GOterm>GO:0035279</GOterm>
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Pages in category "GO:0035279 ! miRNA-mediated gene silencing by mRNA destabilization"
The following 3 pages are in this category, out of 3 total.
