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CAEEL:AKT1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) akt-1
Protein Name(s) Serine/threonine-protein kinase akt-1

Protein kinase B akt-1 PKB akt-1

External Links
UniProt Q17941
EMBL AF072379
AF072380
Z73969
Z73969
Z73969
PIR T43232
T43233
RefSeq NP_001023645.1
NP_001023646.1
NP_001023647.1
UniGene Cel.5036
ProteinModelPortal Q17941
SMR Q17941
BioGrid 44454
IntAct Q17941
PaxDb Q17941
PRIDE Q17941
EnsemblMetazoa C12D8.10a
GeneID 179424
KEGG cel:CELE_C12D8.10
UCSC C12D8.10b.1
CTD 179424
WormBase C12D8.10a
C12D8.10b
C12D8.10c
eggNOG COG0515
GeneTree ENSGT00770000120449
HOGENOM HOG000233033
InParanoid Q17941
KO K04456
OMA EEEGILC
OrthoDB EOG7Q5HCW
PhylomeDB Q17941
Reactome REACT_108273
REACT_183100
REACT_183242
REACT_183243
REACT_197684
REACT_206399
REACT_206872
REACT_221907
REACT_230626
REACT_230822
REACT_232673
REACT_235601
REACT_237300
REACT_247923
REACT_248761
REACT_253534
REACT_255951
REACT_258609
REACT_271346
REACT_82143
SignaLink Q17941
NextBio 905330
Proteomes UP000001940
GO GO:0043025
GO:0005524
GO:0005516
GO:0046872
GO:0004674
GO:0008340
GO:0045087
GO:0008286
GO:0018105
GO:0018107
GO:0006468
Gene3D 2.30.29.30
InterPro IPR000961
IPR011009
IPR001849
IPR011993
IPR017892
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00169
PF00069
PF00433
SMART SM00233
SM00133
SM00220
SUPFAM SSF56112
PROSITE PS51285
PS50003
PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0002376

immune system process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR008271

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

PMID:15068796[1]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000961
InterPro:IPR017892

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:18358814[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:9716402[3]

ISS: Inferred from Sequence or Structural Similarity

F

Seeded From UniProt

Missing: with/from

GO:0005515

protein binding

PMID:15068796[1]

IPI: Inferred from Physical Interaction

UniProtKB:O16850

F

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:17276923[4]

IMP: Inferred from Mutant Phenotype

P

Figure 1 & 3.

complete
CACAO 6797

GO:0005515

protein binding

PMID:15068796[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q2PJ68

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15068796[1]

IPI: Inferred from Physical Interaction

UniProtKB:Q9XTG7

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18309291[5]

IPI: Inferred from Physical Interaction

UniProtKB:G5EFM0

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18358814[2]

IPI: Inferred from Physical Interaction

UniProtKB:O16850

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:19249087[6]

IPI: Inferred from Physical Interaction

UniProtKB:O18178

F

Seeded From UniProt

complete

GO:0005516

calmodulin binding

PMID:17580302[7]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005516

calmodulin binding

PMID:17854888[8]

IPI: Inferred from Physical Interaction

UniProtKB:P62157

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR017441
InterPro:IPR017892

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005622

intracellular

PMID:17276923[4]

IMP: Inferred from Mutant Phenotype

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR002290
InterPro:IPR008271
InterPro:IPR017892

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:15068796[1]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:9716402[3]

ISS: Inferred from Sequence or Structural Similarity

P

Seeded From UniProt

Missing: with/from

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:9716402[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:10638522[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0018105

peptidyl-serine phosphorylation

PMID:18358814[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0018107

peptidyl-threonine phosphorylation

PMID:18358814[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

PMID:17276923[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043025

neuronal cell body

PMID:9716402[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0045087

innate immune response

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 Hertweck, M et al. (2004) C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6 577-88 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 Tullet, JM et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025-38 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Paradis, S & Ruvkun, G (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12 2488-98 PubMed GONUTS page
  4. 4.0 4.1 4.2 Quevedo, C et al. (2007) AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Curr. Biol. 17 286-92 PubMed GONUTS page
  5. Watanabe, S et al. (2008) Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans. EMBO J. 27 1085-96 PubMed GONUTS page
  6. Padmanabhan, S et al. (2009) A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation. Cell 136 939-51 PubMed GONUTS page
  7. Dong, B et al. (2007) Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1. J. Biol. Chem. 282 25131-40 PubMed GONUTS page
  8. Shen, X et al. (2008) Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium 43 444-56 PubMed GONUTS page
  9. Vanfleteren, JR & Braeckman, BP () Mechanisms of life span determination in Caenorhabditis elegans. Neurobiol. Aging 20 487-502 PubMed GONUTS page