CAEEL:AKT1

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	akt-1
Protein Name(s)	Serine/threonine-protein kinase akt-1 Protein kinase B akt-1 PKB akt-1
External Links
UniProt	Q17941
EMBL	AF072379 AF072380 Z73969 Z73969 Z73969
PIR	T43232 T43233
RefSeq	NP_001023645.1 NP_001023646.1 NP_001023647.1
UniGene	Cel.5036
ProteinModelPortal	Q17941
SMR	Q17941
BioGrid	44454
IntAct	Q17941
PaxDb	Q17941
PRIDE	Q17941
EnsemblMetazoa	C12D8.10a
GeneID	179424
KEGG	cel:CELE_C12D8.10
UCSC	C12D8.10b.1
CTD	179424
WormBase	C12D8.10a C12D8.10b C12D8.10c
eggNOG	COG0515
GeneTree	ENSGT00770000120449
HOGENOM	HOG000233033
InParanoid	Q17941
KO	K04456
OMA	EEEGILC
OrthoDB	EOG7Q5HCW
PhylomeDB	Q17941
Reactome	REACT_108273 REACT_183100 REACT_183242 REACT_183243 REACT_197684 REACT_206399 REACT_206872 REACT_221907 REACT_230626 REACT_230822 REACT_232673 REACT_235601 REACT_237300 REACT_247923 REACT_248761 REACT_253534 REACT_255951 REACT_258609 REACT_271346 REACT_82143
SignaLink	Q17941
NextBio	905330
Proteomes	UP000001940
GO	GO:0043025 GO:0005524 GO:0005516 GO:0046872 GO:0004674 GO:0008340 GO:0045087 GO:0008286 GO:0018105 GO:0018107 GO:0006468
Gene3D	2.30.29.30
InterPro	IPR000961 IPR011009 IPR001849 IPR011993 IPR017892 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00169 PF00069 PF00433
SMART	SM00233 SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS50003 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:17276923^[1]	ECO:0000315			P		Figure 1 & 3.	complete CACAO 6797
involved_in	GO:0007635	chemosensory behavior	PMID:20837997^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5EE01	P	has_input:(CHEBI:26710)	Seeded From UniProt	complete
involved_in	GO:1902074	response to salt	PMID:20837997^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5EE01	P	has_input:(CHEBI:26710)	Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:20837997^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5EE01	P	has_input:(CHEBI:26710)	Seeded From UniProt	complete
involved_in	GO:0008582	regulation of synaptic growth at neuromuscular junction	PMID:23665919^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q18223	P		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	PMID:25383666^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0038028)	Seeded From UniProt	complete
enables	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	PMID:25383666^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:9716402^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	PMID:9716402^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:15068796^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:15068796^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(WB:WBGene00000912)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:18358814^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:18358814^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:17276923^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:9716402^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:10638522^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:9716402^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:17854888^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P62157	F		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	PMID:17580302^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18358814^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P34707-1)\|has_direct_input:(UniProtKB:O16850)\|has_direct_input:(UniProtKB:P34707-3)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR017892 InterPro:IPR039027	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441 InterPro:IPR017892	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR017892	P		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039027	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
enables	GO:0005516	calmodulin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0112	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Quevedo, C et al. (2007) AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Curr. Biol. 17 286-92 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Adachi, T et al. (2010) Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics 186 1309-19 PubMed GONUTS page
↑ Hung, WL et al. (2013) Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J. 32 1745-60 PubMed GONUTS page
↑ ^4.0 ^4.1 Nakagawa, A et al. (2014) Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat. Struct. Mol. Biol. 21 1082-90 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Paradis, S & Ruvkun, G (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12 2488-98 PubMed GONUTS page
↑ ^6.0 ^6.1 Hertweck, M et al. (2004) C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6 577-88 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Tullet, JM et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025-38 PubMed GONUTS page
↑ Vanfleteren, JR & Braeckman, BP () Mechanisms of life span determination in Caenorhabditis elegans. Neurobiol. Aging 20 487-502 PubMed GONUTS page
↑ Shen, X et al. (2008) Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium 43 444-56 PubMed GONUTS page
↑ Dong, B et al. (2007) Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1. J. Biol. Chem. 282 25131-40 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17276923-1] 1.0 ^1.1 Quevedo, C et al. (2007) AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans. Curr. Biol. 17 286-92 PubMed GONUTS page

[PMID:20837997-2] 2.0 ^2.1 ^2.2 Adachi, T et al. (2010) Reversal of salt preference is directed by the insulin/PI3K and Gq/PKC signaling in Caenorhabditis elegans. Genetics 186 1309-19 PubMed GONUTS page

[PMID:23665919-3] Hung, WL et al. (2013) Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J. 32 1745-60 PubMed GONUTS page

[PMID:25383666-4] 4.0 ^4.1 Nakagawa, A et al. (2014) Caspase-activated phosphoinositide binding by CNT-1 promotes apoptosis by inhibiting the AKT pathway. Nat. Struct. Mol. Biol. 21 1082-90 PubMed GONUTS page

[PMID:9716402-5] 5.0 ^5.1 ^5.2 ^5.3 Paradis, S & Ruvkun, G (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12 2488-98 PubMed GONUTS page

[PMID:15068796-6] 6.0 ^6.1 Hertweck, M et al. (2004) C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6 577-88 PubMed GONUTS page

[PMID:18358814-7] 7.0 ^7.1 ^7.2 Tullet, JM et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025-38 PubMed GONUTS page

[PMID:10638522-8] Vanfleteren, JR & Braeckman, BP () Mechanisms of life span determination in Caenorhabditis elegans. Neurobiol. Aging 20 487-502 PubMed GONUTS page

[PMID:17854888-9] Shen, X et al. (2008) Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium 43 444-56 PubMed GONUTS page

[PMID:17580302-10] Dong, B et al. (2007) Ca(2+)/calmodulin directly interacts with the pleckstrin homology domain of AKT1. J. Biol. Chem. 282 25131-40 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

CAEEL:AKT1

Contents

Annotations

Notes

References

a

c

d

e

i

k

l

m

n

o

p

r

t

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools