HUMAN:KSYK

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SYK
Protein Name(s)	Tyrosine-protein kinase SYK Spleen tyrosine kinase p72-Syk
External Links
UniProt	P43405
EMBL	Z29630 L28824 AL354862 BC001645 BC011399 BC002962 X73568
CCDS	CCDS47992.1 CCDS6688.1
PIR	A53596
RefSeq	NP_001128524.1 NP_001167638.1 NP_001167639.1 NP_003168.2 XP_005252204.1
UniGene	Hs.371720
PDB	1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG 4I0R 4I0S 4I0T 4PUZ 4PV0 4PX6
PDBsum	1A81 1CSY 1CSZ 1XBA 1XBB 1XBC 3BUW 3EMG 3FQE 3FQH 3FQS 3SRV 3TUB 3TUC 3TUD 3VF8 3VF9 4DFL 4DFN 4F4P 4FL1 4FL2 4FL3 4FYN 4FYO 4FZ6 4FZ7 4GFG 4I0R 4I0S 4I0T 4PUZ 4PV0 4PX6
ProteinModelPortal	P43405
SMR	P43405
BioGrid	112717
DIP	DIP-253N
IntAct	P43405
MINT	MINT-148486
STRING	9606.ENSP00000364898
BindingDB	P43405
ChEMBL	CHEMBL2599
GuidetoPHARMACOLOGY	2230
PhosphoSite	P43405
DMDM	1174527
MaxQB	P43405
PaxDb	P43405
PeptideAtlas	P43405
PRIDE	P43405
DNASU	6850
Ensembl	ENST00000375746 ENST00000375747 ENST00000375751 ENST00000375754
GeneID	6850
KEGG	hsa:6850
UCSC	uc004aqz.3 uc004ara.3
CTD	6850
GeneCards	GC09P093564
HGNC	HGNC:11491
HPA	CAB007773 HPA001384
MIM	600085
neXtProt	NX_P43405
PharmGKB	PA36273
eggNOG	COG0515
GeneTree	ENSGT00760000118799
HOGENOM	HOG000113264
HOVERGEN	HBG001540
InParanoid	P43405
KO	K05855
OMA	KGYYQMK
OrthoDB	EOG7MWGWD
PhylomeDB	P43405
TreeFam	TF351629
BRENDA	2.7.10.2
Reactome	REACT_118700 REACT_147814 REACT_15523 REACT_160086 REACT_160158 REACT_160274 REACT_163701 REACT_163769 REACT_163834 REACT_163936 REACT_1695 REACT_23787 REACT_27283
SignaLink	P43405
ChiTaRS	SYK
EvolutionaryTrace	P43405
GeneWiki	Syk
GenomeRNAi	6850
NextBio	26739
PRO	PR:P43405
Proteomes	UP000005640
Bgee	P43405
CleanEx	HS_SYK
ExpressionAtlas	P43405
Genevestigator	P43405
GO	GO:0019815 GO:0005737 GO:0005829 GO:0032009 GO:0005634 GO:0005886 GO:0043234 GO:0042101 GO:0005524 GO:0005178 GO:0004715 GO:0004672 GO:0004674 GO:0004713 GO:0004716 GO:0007257 GO:0002250 GO:0001525 GO:0050853 GO:0043366 GO:0007596 GO:0048514 GO:0008283 GO:0071226 GO:0042742 GO:0007167 GO:0038095 GO:0038096 GO:0045087 GO:0007229 GO:0002366 GO:0007159 GO:0019370 GO:0001945 GO:0002281 GO:0002283 GO:0030593 GO:0009887 GO:0030168 GO:0046638 GO:0046641 GO:0045579 GO:0045780 GO:0050850 GO:0033630 GO:0050715 GO:0045588 GO:0045425 GO:0045401 GO:0043306 GO:0050731 GO:0046777 GO:0006468 GO:0090237 GO:0070372 GO:0043313 GO:0050764 GO:0010543 GO:0090330 GO:0051090 GO:0032928 GO:0002554 GO:0042991 GO:0016032
Gene3D	1.10.930.10 3.30.505.10
InterPro	IPR011009 IPR023420 IPR000719 IPR017441 IPR001245 IPR000980 IPR008266 IPR020635 IPR012234
Pfam	PF07714 PF00017
PIRSF	PIRSF000604
PRINTS	PR00401 PR00109
SMART	SM00252 SM00219
SUPFAM	SSF55550 SSF56112
PROSITE	PS00107 PS50011 PS00109 PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045579	positive regulation of B cell differentiation	PMID:18369315^[1]	ECO:0000315			P		figure 4	complete CACAO 6490
	GO:0004672	protein kinase activity	PMID:18369315^[1]	ECO:0000314			F		figure 3	complete CACAO 6491
	GO:0006468	protein phosphorylation	PMID:18818202^[2]	ECO:0000314			P		Figure 4B and 4C	complete CACAO 6493
	GO:0006468	protein phosphorylation	PMID:17681949^[3]	ECO:0000314			P		figure 5 shows SLP-65 phosphorylation by Syk	complete CACAO 6517
	GO:0004672	protein kinase activity	PMID:18818202^[2]	ECO:0000314			F		figure 6	complete CACAO 6494
	GO:1901224	positive regulation of NIK/NF-kappaB cascade	PMID:19151749^[4]	ECO:0000314			P		Fig 1.B Increased TNF signaling by Syk here demonstrates increased NF-kB activation.	complete CACAO 8563
	GO:0006468	protein phosphorylation	PMID:19151749^[4]	ECO:0000315			P		1.B Syk phosphorylates TRIP.	complete CACAO 8564
	GO:0006468	protein phosphorylation	PMID:19151749^[4]	ECO:0000314			P		Fig 1.C Syk phosphorylated TRIP.	complete CACAO 8565
Colocalizes with	GO:0005737	cytoplasm	PMID:19151749^[4]	ECO:0000314			C		Figure 4c and D show that when SKY and TRIAP in Human breast cells MCF7 cells are coexpressed then both are found in the cytoplasm. This is not normal for SKY which is normally found throughout the cell.	complete CACAO 9148
	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	PMID:19151749^[4]	ECO:0000315			P		SKY expression led to increased activity of the the TNF signaling pathway of resulting in activation of NF-kB as shown in Figure 5 particularly in C and D. Thus sky positively regulates TNF mediated signaling pathway.	complete CACAO 9160
involved_in	GO:0038156	interleukin-3-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
enables	GO:0016170	interleukin-15 receptor binding	PMID:15123770^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13261	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:12051764^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:12051764^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96P31	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:28386764^[7]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:29235464^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0071404	cellular response to low-density lipoprotein particle stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:17681949^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:18818202^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045579	positive regulation of B cell differentiation	PMID:18369315^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	PMID:19151749^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	PMID:20624904^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6GX35	F		Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0090237	regulation of arachidonic acid secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0071226	cellular response to molecule of fungal origin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0070372	regulation of ERK1 and ERK2 cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1N9Y5	P		Seeded From UniProt	complete
involved_in	GO:0050764	regulation of phagocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0045780	positive regulation of bone resorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0043313	regulation of neutrophil degranulation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0032928	regulation of superoxide anion generation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
part_of	GO:0032009	early phagosome	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	C		Seeded From UniProt	complete
involved_in	GO:0030593	neutrophil chemotaxis	PMID:12885943^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010543	regulation of platelet activation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:12885943^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0007159	leukocyte cell-cell adhesion	PMID:12885943^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1N9Y5	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:8163536^[11]	ECO:0000305	curator inference used in manual assertion	GO:0004715	C		Seeded From UniProt	complete
enables	GO:0005178	integrin binding	PMID:12885943^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05107	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:8163536^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:12885943^[10]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002554	serotonin secretion by platelet	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0002366	leukocyte activation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0002283	neutrophil activation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0002281	macrophage activation involved in immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:F1N9Y5	P		Seeded From UniProt	complete
involved_in	GO:0001945	lymph vessel development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48025	P		Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479 UniProtKB:F1N9Y5	P		Seeded From UniProt	complete
involved_in	GO:0046641	positive regulation of alpha-beta T cell proliferation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0045579	positive regulation of B cell differentiation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479 UniProtKB:P43405	P		Seeded From UniProt	complete
involved_in	GO:0043306	positive regulation of mast cell degranulation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479 RGD:3796	P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0002283	neutrophil activation involved in immune response	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0002281	macrophage activation involved in immune response	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99515 PANTHER:PTN000700479	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700479 UniProtKB:F1N9Y5	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8657103^[13]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8629002^[14]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:22041900^[15]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:18818202^[2]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:17993265^[16]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10648173^[17]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	PMID:23071339^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042101	T cell receptor complex	PMID:8176201^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23071339^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006606	protein import into nucleus	PMID:23071339^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23071339^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23071339^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:23071339^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0090330	regulation of platelet aggregation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0090237	regulation of arachidonic acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0071404	cellular response to low-density lipoprotein particle stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0071226	cellular response to molecule of fungal origin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0070372	regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0050850	positive regulation of calcium-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0050764	regulation of phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0048514	blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0046641	positive regulation of alpha-beta T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0046638	positive regulation of alpha-beta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0045780	positive regulation of bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0045588	positive regulation of gamma-delta T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0045579	positive regulation of B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0045425	positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0045401	positive regulation of interleukin-3 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0043366	beta selection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0043313	regulation of neutrophil degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0043306	positive regulation of mast cell degranulation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0042742	defense response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	F		Seeded From UniProt	complete
involved_in	GO:0038156	interleukin-3-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	F		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	C		Seeded From UniProt	complete
involved_in	GO:0032928	regulation of superoxide anion generation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0032481	positive regulation of type I interferon production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
part_of	GO:0032009	early phagosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	C		Seeded From UniProt	complete
involved_in	GO:0031623	receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	F		Seeded From UniProt	complete
part_of	GO:0019815	B cell receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	C		Seeded From UniProt	complete
involved_in	GO:0019370	leukotriene biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0010543	regulation of platelet activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0007257	activation of JUN kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0007167	enzyme linked receptor protein signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	F		Seeded From UniProt	complete
involved_in	GO:0002554	serotonin secretion by platelet	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0002366	leukocyte activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0002283	neutrophil activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0002281	macrophage activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0002092	positive regulation of receptor internalization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0001945	lymph vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0001820	serotonin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48025 ensembl:ENSMUSP00000113852	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012234 InterPro:IPR023420	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR012234 InterPro:IPR017441	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012234	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR012234 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR012234	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	PMID:7477352^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038110	interleukin-2-mediated signaling pathway	Reactome:R-HSA-9020558	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-508282 Reactome:R-HSA-429441	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-5607748 Reactome:R-HSA-983707 Reactome:R-HSA-983703 Reactome:R-HSA-983700 Reactome:R-HSA-9606151 Reactome:R-HSA-5684801 Reactome:R-HSA-5621370 Reactome:R-HSA-5621366 Reactome:R-HSA-5621363 Reactome:R-HSA-5621347 Reactome:R-HSA-508292 Reactome:R-HSA-508282 Reactome:R-HSA-453200 Reactome:R-HSA-453183 Reactome:R-HSA-437118 Reactome:R-HSA-434836 Reactome:R-HSA-429449 Reactome:R-HSA-429441 Reactome:R-HSA-429415 Reactome:R-HSA-2730886 Reactome:R-HSA-2730884 Reactome:R-HSA-2730851 Reactome:R-HSA-2730843 Reactome:R-HSA-2730833 Reactome:R-HSA-2454240 Reactome:R-HSA-2424487 Reactome:R-HSA-2424486 Reactome:R-HSA-2424484 Reactome:R-HSA-2424482 Reactome:R-HSA-2424480 Reactome:R-HSA-2396594 Reactome:R-HSA-2395801 Reactome:R-HSA-2395412 Reactome:R-HSA-2197697 Reactome:R-HSA-210289 Reactome:R-HSA-2029467 Reactome:R-HSA-2029458 Reactome:R-HSA-2029453 Reactome:R-HSA-2029452 Reactome:R-HSA-2029451 Reactome:R-HSA-2029273 Reactome:R-HSA-2029272 Reactome:R-HSA-2029271 Reactome:R-HSA-2029270 Reactome:R-HSA-2029268 Reactome:R-HSA-139842 Reactome:R-HSA-1112666	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Reactome:R-HSA-453200	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	Reactome:R-HSA-429449 Reactome:R-HSA-2424487 Reactome:R-HSA-2424486 Reactome:R-HSA-2424484 Reactome:R-HSA-2396594 Reactome:R-HSA-2395801 Reactome:R-HSA-2395412 Reactome:R-HSA-2029453	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0091	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Kulathu, Y et al. (2008) The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. EMBO J. 27 1333-44 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Tsang, E et al. (2008) Molecular mechanism of the Syk activation switch. J. Biol. Chem. 283 32650-9 PubMed GONUTS page
↑ ^3.0 ^3.1 Abudula, A et al. (2007) SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of Syk. J. Biol. Chem. 282 29059-66 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Zhou, Q & Geahlen, RL (2009) The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells. Oncogene 28 1348-56 PubMed GONUTS page
↑ Ratthé, C & Girard, D (2004) Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain. J. Leukoc. Biol. 76 162-8 PubMed GONUTS page
↑ ^6.0 ^6.1 Xu, MJ et al. (2002) SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Biochem. Biophys. Res. Commun. 293 1037-46 PubMed GONUTS page
↑ Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ Knoll, M et al. (2017) SYK kinase mediates brown fat differentiation and activation. Nat Commun 8 2115 PubMed GONUTS page
↑ Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Willeke, T et al. (2003) A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils. J. Leukoc. Biol. 74 260-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Law, CL et al. (1994) Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. J. Biol. Chem. 269 12310-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Law, CL et al. (1996) Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol. Cell. Biol. 16 1305-15 PubMed GONUTS page
↑ Rawlings, DJ et al. (1996) Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271 822-5 PubMed GONUTS page
↑ Gorjestani, S et al. (2011) Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J. Biol. Chem. 286 43651-9 PubMed GONUTS page
↑ Iwaki, S et al. (2008) Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells. Cell. Signal. 20 195-205 PubMed GONUTS page
↑ Baldock, D et al. (2000) Purification and characterization of human Syk produced using a baculovirus expression system. Protein Expr. Purif. 18 86-94 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 Uckun, FM et al. (2012) Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proc. Natl. Acad. Sci. U.S.A. 109 18072-7 PubMed GONUTS page
↑ Chan, AC et al. (1994) Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J. Immunol. 152 4758-66 PubMed GONUTS page
↑ Turner, M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378 298-302 PubMed GONUTS page

[PMID:18369315-1] 1.0 ^1.1 ^1.2 Kulathu, Y et al. (2008) The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development. EMBO J. 27 1333-44 PubMed GONUTS page

[PMID:18818202-2] 2.0 ^2.1 ^2.2 ^2.3 Tsang, E et al. (2008) Molecular mechanism of the Syk activation switch. J. Biol. Chem. 283 32650-9 PubMed GONUTS page

[PMID:17681949-3] 3.0 ^3.1 Abudula, A et al. (2007) SLP-65 signal transduction requires Src homology 2 domain-mediated membrane anchoring and a kinase-independent adaptor function of Syk. J. Biol. Chem. 282 29059-66 PubMed GONUTS page

[PMID:19151749-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Zhou, Q & Geahlen, RL (2009) The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells. Oncogene 28 1348-56 PubMed GONUTS page

[PMID:15123770-5] Ratthé, C & Girard, D (2004) Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent mechanism: importance of the IL-15Ralpha chain. J. Leukoc. Biol. 76 162-8 PubMed GONUTS page

[PMID:12051764-6] 6.0 ^6.1 Xu, MJ et al. (2002) SPAP2, an Ig family receptor containing both ITIMs and ITAMs. Biochem. Biophys. Res. Commun. 293 1037-46 PubMed GONUTS page

[PMID:28386764-7] Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:29235464-8] Knoll, M et al. (2017) SYK kinase mediates brown fat differentiation and activation. Nat Commun 8 2115 PubMed GONUTS page

[PMID:20624904-9] Mehlitz, A et al. (2010) Tarp regulates early Chlamydia-induced host cell survival through interactions with the human adaptor protein SHC1. J. Cell Biol. 190 143-57 PubMed GONUTS page

[PMID:12885943-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Willeke, T et al. (2003) A role for Syk-kinase in the control of the binding cycle of the beta2 integrins (CD11/CD18) in human polymorphonuclear neutrophils. J. Leukoc. Biol. 74 260-9 PubMed GONUTS page

[PMID:8163536-11] 11.0 ^11.1 Law, CL et al. (1994) Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex. J. Biol. Chem. 269 12310-9 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 ^12.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8657103-13] Law, CL et al. (1996) Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol. Cell. Biol. 16 1305-15 PubMed GONUTS page

[PMID:8629002-14] Rawlings, DJ et al. (1996) Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science 271 822-5 PubMed GONUTS page

[PMID:22041900-15] Gorjestani, S et al. (2011) Phospholipase Cγ2 (PLCγ2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J. Biol. Chem. 286 43651-9 PubMed GONUTS page

[PMID:17993265-16] Iwaki, S et al. (2008) Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells. Cell. Signal. 20 195-205 PubMed GONUTS page

[PMID:10648173-17] Baldock, D et al. (2000) Purification and characterization of human Syk produced using a baculovirus expression system. Protein Expr. Purif. 18 86-94 PubMed GONUTS page

[PMID:23071339-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 Uckun, FM et al. (2012) Serine phosphorylation by SYK is critical for nuclear localization and transcription factor function of Ikaros. Proc. Natl. Acad. Sci. U.S.A. 109 18072-7 PubMed GONUTS page

[PMID:8176201-19] Chan, AC et al. (1994) Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling. J. Immunol. 152 4758-66 PubMed GONUTS page

[PMID:7477352-20] Turner, M et al. (1995) Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378 298-302 PubMed GONUTS page

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HUMAN:KSYK

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