CAEEL:PMK1

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	pmk-1
Protein Name(s)	Mitogen-activated protein kinase pmk-1 Stress-activated protein kinase pmk-1 p38 MAP kinase 1
External Links
UniProt	Q17446
EMBL	FO080124
PIR	T29750
RefSeq	NP_501365.1
UniGene	Cel.12534
ProteinModelPortal	Q17446
SMR	Q17446
BioGrid	56238
DIP	DIP-26892N
IntAct	Q17446
MINT	MINT-1037719
STRING	6239.B0218.3
PaxDb	Q17446
PRIDE	Q17446
EnsemblMetazoa	B0218.3
GeneID	191743
KEGG	cel:CELE_B0218.3
UCSC	B0218.3
CTD	191743
WormBase	B0218.3
eggNOG	COG0515
GeneTree	ENSGT00550000074271
HOGENOM	HOG000233024
InParanoid	Q17446
KO	K04441
OMA	FQKNVAF
OrthoDB	EOG7PCJGV
PhylomeDB	Q17446
Reactome	REACT_183100 REACT_184347 REACT_239816 REACT_242972 REACT_246696 REACT_249288 REACT_250015 REACT_250046 REACT_255121 REACT_271173
SignaLink	Q17446
NextBio	950180
PRO	PR:Q17446
Proteomes	UP000001940
GO	GO:0005829 GO:0005634 GO:0005524 GO:0004707 GO:0004672 GO:0004674 GO:0008134 GO:0050829 GO:0050830 GO:0006972 GO:0045087 GO:0035556 GO:0000165 GO:0038066 GO:0018105 GO:1900182 GO:0045944 GO:1902097 GO:0012501 GO:0006468 GO:0006970 GO:0000302 GO:0000303
InterPro	IPR011009 IPR003527 IPR008352 IPR000719 IPR017441 IPR002290
Pfam	PF00069
PRINTS	PR01773
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS00107 PS50011

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004707	MAP kinase activity	PMID:16166371^[1]	ECO:0000314			F		figure 3	complete CACAO 6790
	GO:0018105	peptidyl-serine phosphorylation	PMID:16166371^[1]	ECO:0000314			P		Figure 3	complete CACAO 6791
involved_in	GO:0002225	positive regulation of antimicrobial peptide production	PMID:22470487^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0050832)	Seeded From UniProt	complete
involved_in	GO:1901244	positive regulation of transcription from RNA polymerase II promoter involved in defense response to fungus	PMID:22470487^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0050832)	Seeded From UniProt	complete
involved_in	GO:1900150	regulation of defense response to fungus	PMID:22470487^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O44664) part_of:(GO:0050832) part_of:(GO:0045087)	Seeded From UniProt	complete
involved_in	GO:0035095	behavioral response to nicotine	PMID:25851606^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:25274306^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9N3T5	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:25274306^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:24972867^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900426	positive regulation of defense response to bacterium	PMID:22554143^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q10038	P	happens_during:(WBls:0000109)	Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:18394898^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050832	defense response to fungus	PMID:18394898^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0045087)	Seeded From UniProt	complete
involved_in	GO:0093002	response to nematicide	PMID:15256590^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:R4I3J1)\|has_input:(UniProtKB:S5VRK7)	Seeded From UniProt	complete
involved_in	GO:1901215	negative regulation of neuron death	PMID:21857923^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0033554)	Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	PMID:11751572^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00004758	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:16166371^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:16166371^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:17975555^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088252	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:17975555^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088252	P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:17975555^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088252	P		Seeded From UniProt	complete
involved_in	GO:1902097	positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium	PMID:17888400^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(WB:WBGene00003999)	Seeded From UniProt	complete
involved_in	GO:1900182	positive regulation of protein localization to nucleus	PMID:16166371^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0000302) has_regulation_target:(UniProtKB:P34707) occurs_in:(WBbt:0005772)	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:12142542^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:19454349^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088252	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19454349^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088252	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:12526744^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:19454349^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088252	P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	PMID:12142542^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038066	p38MAPK cascade	PMID:16166371^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P	part_of:(GO:0000302)\|part_of:(GO:0000303)	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:16166371^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P34707)	Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	PMID:12526744^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20369020^[16]	ECO:0000353	physical interaction evidence used in manual assertion	WB:WBGene00000223	F		Seeded From UniProt	complete
involved_in	GO:0006972	hyperosmotic response	PMID:10393177^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000004103	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11703092^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:20369020^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:20133945^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20133945^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16166371^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P34707)	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:11703092^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:20369020^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(WB:WBGene00000223)	Seeded From UniProt	complete
involved_in	GO:0000303	response to superoxide	PMID:16166371^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000302	response to reactive oxygen species	PMID:16166371^[1]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:18394898^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0050832)	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:11703092^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006970	response to osmotic stress	PMID:11703092^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:11703092^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[20]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008352	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008352 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008352	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Inoue, H et al. (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 19 2278-83 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Labed, SA et al. (2012) The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression. PLoS ONE 7 e33887 PubMed GONUTS page
↑ Matsunaga, Y et al. (2015) Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle. Mol. Biol. Cell 26 2096-111 PubMed GONUTS page
↑ ^4.0 ^4.1 Pellegrino, MW et al. (2014) Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature 516 414-7 PubMed GONUTS page
↑ Kong, C et al. (2014) Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation. Biol Open 3 644-55 PubMed GONUTS page
↑ Twumasi-Boateng, K et al. (2012) An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. Aging Cell 11 659-67 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Pujol, N et al. (2008) Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr. Biol. 18 481-9 PubMed GONUTS page
↑ Huffman, DL et al. (2004) Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc. Natl. Acad. Sci. U.S.A. 101 10995-1000 PubMed GONUTS page
↑ Yuan, Y et al. (2011) Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans. PLoS ONE 6 e22354 PubMed GONUTS page
↑ Tanaka-Hino, M et al. (2002) SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep. 3 56-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Tenor, JL & Aballay, A (2008) A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. EMBO Rep. 9 103-9 PubMed GONUTS page
↑ Kurz, CL et al. (2007) Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade. Biochem. Biophys. Res. Commun. 363 438-43 PubMed GONUTS page
↑ ^13.0 ^13.1 Kim, DH et al. (2002) A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297 623-6 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Anyanful, A et al. (2009) Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe 5 450-62 PubMed GONUTS page
↑ ^15.0 ^15.1 Aballay, A et al. (2003) Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway. Curr. Biol. 13 47-52 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Shivers, RP et al. (2010) Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet. 6 e1000892 PubMed GONUTS page
↑ Kawasaki, M et al. (1999) A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. EMBO J. 18 3604-15 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Berman, K et al. (2001) Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Mol. Cell Biol. Res. Commun. 4 337-44 PubMed GONUTS page
↑ ^19.0 ^19.1 Bolz, DD et al. (2010) A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. J. Biol. Chem. 285 10832-40 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16166371-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 ^1.8 ^1.9 Inoue, H et al. (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 19 2278-83 PubMed GONUTS page

[PMID:22470487-2] 2.0 ^2.1 ^2.2 Labed, SA et al. (2012) The pseudokinase NIPI-4 is a novel regulator of antimicrobial peptide gene expression. PLoS ONE 7 e33887 PubMed GONUTS page

[PMID:25851606-3] Matsunaga, Y et al. (2015) Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle. Mol. Biol. Cell 26 2096-111 PubMed GONUTS page

[PMID:25274306-4] 4.0 ^4.1 Pellegrino, MW et al. (2014) Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature 516 414-7 PubMed GONUTS page

[PMID:24972867-5] Kong, C et al. (2014) Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation. Biol Open 3 644-55 PubMed GONUTS page

[PMID:22554143-6] Twumasi-Boateng, K et al. (2012) An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. Aging Cell 11 659-67 PubMed GONUTS page

[PMID:18394898-7] 7.0 ^7.1 ^7.2 Pujol, N et al. (2008) Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr. Biol. 18 481-9 PubMed GONUTS page

[PMID:15256590-8] Huffman, DL et al. (2004) Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins. Proc. Natl. Acad. Sci. U.S.A. 101 10995-1000 PubMed GONUTS page

[PMID:21857923-9] Yuan, Y et al. (2011) Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans. PLoS ONE 6 e22354 PubMed GONUTS page

[PMID:11751572-10] Tanaka-Hino, M et al. (2002) SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep. 3 56-62 PubMed GONUTS page

[PMID:17975555-11] 11.0 ^11.1 ^11.2 Tenor, JL & Aballay, A (2008) A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. EMBO Rep. 9 103-9 PubMed GONUTS page

[PMID:17888400-12] Kurz, CL et al. (2007) Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade. Biochem. Biophys. Res. Commun. 363 438-43 PubMed GONUTS page

[PMID:12142542-13] 13.0 ^13.1 Kim, DH et al. (2002) A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297 623-6 PubMed GONUTS page

[PMID:19454349-14] 14.0 ^14.1 ^14.2 Anyanful, A et al. (2009) Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe 5 450-62 PubMed GONUTS page

[PMID:12526744-15] 15.0 ^15.1 Aballay, A et al. (2003) Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway. Curr. Biol. 13 47-52 PubMed GONUTS page

[PMID:20369020-16] 16.0 ^16.1 ^16.2 Shivers, RP et al. (2010) Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet. 6 e1000892 PubMed GONUTS page

[PMID:10393177-17] Kawasaki, M et al. (1999) A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. EMBO J. 18 3604-15 PubMed GONUTS page

[PMID:11703092-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Berman, K et al. (2001) Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Mol. Cell Biol. Res. Commun. 4 337-44 PubMed GONUTS page

[PMID:20133945-19] 19.0 ^19.1 Bolz, DD et al. (2010) A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. J. Biol. Chem. 285 10832-40 PubMed GONUTS page

[PMID:21873635-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:PMK1

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