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CAEEL:PMK1

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) pmk-1
Protein Name(s) Mitogen-activated protein kinase pmk-1

Stress-activated protein kinase pmk-1 p38 MAP kinase 1

External Links
UniProt Q17446
EMBL FO080124
PIR T29750
RefSeq NP_501365.1
UniGene Cel.12534
ProteinModelPortal Q17446
SMR Q17446
BioGrid 56238
DIP DIP-26892N
IntAct Q17446
MINT MINT-1037719
STRING 6239.B0218.3
PaxDb Q17446
PRIDE Q17446
EnsemblMetazoa B0218.3
GeneID 191743
KEGG cel:CELE_B0218.3
UCSC B0218.3
CTD 191743
WormBase B0218.3
eggNOG COG0515
GeneTree ENSGT00550000074271
HOGENOM HOG000233024
InParanoid Q17446
KO K04441
OMA FQKNVAF
OrthoDB EOG7PCJGV
PhylomeDB Q17446
Reactome REACT_183100
REACT_184347
REACT_239816
REACT_242972
REACT_246696
REACT_249288
REACT_250015
REACT_250046
REACT_255121
REACT_271173
SignaLink Q17446
NextBio 950180
PRO PR:Q17446
Proteomes UP000001940
GO GO:0005829
GO:0005634
GO:0005524
GO:0004707
GO:0004672
GO:0004674
GO:0008134
GO:0050829
GO:0050830
GO:0006972
GO:0045087
GO:0035556
GO:0000165
GO:0038066
GO:0018105
GO:1900182
GO:0045944
GO:1902097
GO:0012501
GO:0006468
GO:0006970
GO:0000302
GO:0000303
InterPro IPR011009
IPR003527
IPR008352
IPR000719
IPR017441
IPR002290
Pfam PF00069
PRINTS PR01773
SMART SM00220
SUPFAM SSF56112
PROSITE PS01351
PS00107
PS50011

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000165

MAPK cascade

PMID:11751572[1]

IGI: Inferred from Genetic Interaction

WB:WBGene00004758

P

Seeded From UniProt

complete

GO:0000166

nucleotide binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

GO:0000302

response to reactive oxygen species

PMID:16166371[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0000303

response to superoxide

PMID:16166371[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0004672

protein kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

PMID:11703092[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004672

protein kinase activity

PMID:20369020[4]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

GO:0004674

protein serine/threonine kinase activity

PMID:16166371[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004707

MAP kinase activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR003527
InterPro:IPR008352

F

Seeded From UniProt

complete

GO:0004707

MAP kinase activity

PMID:16166371[2]

IDA: Inferred from Direct Assay

F

figure 3

complete
CACAO 6790

GO:0004707

MAP kinase activity

GO_REF:0000003

IEA: Inferred from Electronic Annotation

EC:2.7.11.24

F

Seeded From UniProt

complete

GO:0018105

peptidyl-serine phosphorylation

PMID:16166371[2]

IDA: Inferred from Direct Assay

P

Figure 3

complete
CACAO 6791

GO:0004707

MAP kinase activity

PMID:11703092[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0004707

MAP kinase activity

PMID:16166371[2]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR003527
InterPro:IPR008352
InterPro:IPR017441

F

Seeded From UniProt

complete

GO:0005524

ATP binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:20133945[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005829

cytosol

PMID:20133945[5]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000719
InterPro:IPR002290
InterPro:IPR003527
InterPro:IPR008352

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:11703092[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006468

protein phosphorylation

PMID:20369020[4]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006970

response to osmotic stress

PMID:11703092[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006972

hyperosmotic response

PMID:10393177[6]

IGI: Inferred from Genetic Interaction

SGD:S000004103

P

Seeded From UniProt

complete

GO:0008134

transcription factor binding

PMID:20369020[4]

IPI: Inferred from Physical Interaction

WB:WBGene00000223

F

Seeded From UniProt

complete

GO:0012501

programmed cell death

PMID:12526744[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0016301

kinase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

GO:0016310

phosphorylation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

GO:0016740

transferase activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

GO:0018105

peptidyl-serine phosphorylation

PMID:16166371[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0018105

peptidyl-serine phosphorylation

PMID:16166371[2]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0035556

intracellular signal transduction

PMID:11703092[3]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0038066

p38MAPK cascade

PMID:12142542[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0038066

p38MAPK cascade

PMID:16166371[2]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0045087

innate immune response

PMID:12526744[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045087

innate immune response

PMID:19454349[9]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:19454349[9]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:12142542[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:17975555[10]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:17975555[10]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:19454349[9]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

Seeded From UniProt

complete

GO:0050830

defense response to Gram-positive bacterium

PMID:17975555[10]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

Seeded From UniProt

complete

GO:1900182

positive regulation of protein localization to nucleus

PMID:16166371[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1901215

negative regulation of neuron death

PMID:21857923[11]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:1902097

positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium

PMID:17888400[12]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Tanaka-Hino, M et al. (2002) SEK-1 MAPKK mediates Ca2+ signaling to determine neuronal asymmetric development in Caenorhabditis elegans. EMBO Rep. 3 56-62 PubMed GONUTS page
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 Inoue, H et al. (2005) The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response. Genes Dev. 19 2278-83 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 3.4 Berman, K et al. (2001) Isolation and characterization of pmk-(1-3): three p38 homologs in Caenorhabditis elegans. Mol. Cell Biol. Res. Commun. 4 337-44 PubMed GONUTS page
  4. 4.0 4.1 4.2 Shivers, RP et al. (2010) Phosphorylation of the conserved transcription factor ATF-7 by PMK-1 p38 MAPK regulates innate immunity in Caenorhabditis elegans. PLoS Genet. 6 e1000892 PubMed GONUTS page
  5. 5.0 5.1 Bolz, DD et al. (2010) A conserved PMK-1/p38 MAPK is required in caenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. J. Biol. Chem. 285 10832-40 PubMed GONUTS page
  6. Kawasaki, M et al. (1999) A Caenorhabditis elegans JNK signal transduction pathway regulates coordinated movement via type-D GABAergic motor neurons. EMBO J. 18 3604-15 PubMed GONUTS page
  7. 7.0 7.1 Aballay, A et al. (2003) Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway. Curr. Biol. 13 47-52 PubMed GONUTS page
  8. 8.0 8.1 Kim, DH et al. (2002) A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science 297 623-6 PubMed GONUTS page
  9. 9.0 9.1 9.2 Anyanful, A et al. (2009) Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe 5 450-62 PubMed GONUTS page
  10. 10.0 10.1 10.2 Tenor, JL & Aballay, A (2008) A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. EMBO Rep. 9 103-9 PubMed GONUTS page
  11. Yuan, Y et al. (2011) Dysregulated LRRK2 signaling in response to endoplasmic reticulum stress leads to dopaminergic neuron degeneration in C. elegans. PLoS ONE 6 e22354 PubMed GONUTS page
  12. Kurz, CL et al. (2007) Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade. Biochem. Biophys. Res. Commun. 363 438-43 PubMed GONUTS page