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This is your chance to make annotations OR challenge other team's annotations. You may also DEFEND or suggest improvements to your own annotations IF they have been challenged. Please note, although we ENCOURAGE challenges, an excess of identical challenges that do not appear to be applicable to the annotation or well thought out will be considered spam and ignored.

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PMID:19454349

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Citation

Anyanful, A, Easley, KA, Benian, GM and Kalman, D (2009) Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe 5:450-62

Abstract

Caenorhabditis elegans exhibits avoidance behavior when presented with diverse bacterial pathogens. We hypothesized that exposure to pathogens might not only cause worms to move away but also simultaneously activate pathways that promote resistance to the pathogen. We show that brief exposure to virulent or avirulent strains of the bacterial pathogen enteropathogenic E. coli (EPEC) "immunizes"C. elegans to survive a subsequent exposure that would otherwise prove lethal, a phenomenon we refer to as "conditioning." Conditioning requires dopaminergic neurons; the p38 MAP kinase pathway, which regulates innate immunity; and the insulin/IGFR pathway, which regulates lifespan. Our findings suggest that the molecular pathways that control innate immunity and lifespan may be regulated or "conditioned" by exposure to pathogens to allow survival in noxious environments.

Links

PubMed PMC2992947 Online version:10.1016/j.chom.2009.04.012

Keywords

Animals; Caenorhabditis elegans/genetics; Caenorhabditis elegans/immunology; Caenorhabditis elegans/microbiology; Caenorhabditis elegans/physiology; Caenorhabditis elegans Proteins/genetics; Caenorhabditis elegans Proteins/immunology; Disease Models, Animal; Enteropathogenic Escherichia coli/pathogenicity; Enteropathogenic Escherichia coli/physiology; Host-Pathogen Interactions; Humans; Immunity, Innate; Longevity; Signal Transduction; Virulence; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/immunology

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status

WB:daf-16

GO:0045087

innate immune response

IMP: Inferred from Mutant Phenotype

WB:WBVar00088538
WB:WBVar00088974
WB:WBVar00089216
WB:WBVar00275574

P

From WB


WB:daf-16

GO:0005737

cytoplasm

IDA: Inferred from Direct Assay

C

From WB


WB:daf-16

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IMP: Inferred from Mutant Phenotype

WB:WBVar00089216

P

From WB


WB:daf-16

GO:0050829

defense response to Gram-negative bacterium

IMP: Inferred from Mutant Phenotype

WB:WBVar00088538
WB:WBVar00088974
WB:WBVar00089216
WB:WBVar00275574

P

From WB


WB:daf-16

GO:0005634

nucleus

IDA: Inferred from Direct Assay

C

From WB


WB:pmk-1

GO:0050829

defense response to Gram-negative bacterium

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

From WB


WB:pmk-1

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

From WB


WB:pmk-1

GO:0045087

innate immune response

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

From WB


WB:dop-3

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IMP: Inferred from Mutant Phenotype

WB:WBVar00275094

P

From WB


WB:sek-1

GO:0045087

innate immune response

IMP: Inferred from Mutant Phenotype

WB:WBVar00088241

P

From WB


WB:sek-1

GO:0050829

defense response to Gram-negative bacterium

IMP: Inferred from Mutant Phenotype

WB:WBVar00088241

P

From WB


WB:aqp-1

GO:0045087

innate immune response

IGI: Inferred from Genetic Interaction

WB:WBGene00000912

P

From WB


WB:aqp-1

GO:0045087

innate immune response

IGI: Inferred from Genetic Interaction

WB:WBGene00000898

P

From WB


WB:aqp-1

GO:0045087

innate immune response

IGI: Inferred from Genetic Interaction

WB:WBGene00004055

P

From WB


WB:aqp-1

GO:0050829

defense response to Gram-negative bacterium

IMP: Inferred from Mutant Phenotype

WB:WBVar00251211

P

From WB


WB:aqp-1

GO:0050829

defense response to Gram-negative bacterium

IGI: Inferred from Genetic Interaction

WB:WBGene00004055

P

From WB


WB:aqp-1

GO:0050829

defense response to Gram-negative bacterium

IGI: Inferred from Genetic Interaction

WB:WBGene00000912

P

From WB


WB:aqp-1

GO:0050829

defense response to Gram-negative bacterium

IGI: Inferred from Genetic Interaction

WB:WBGene00000898

P

From WB


WB:aqp-1

GO:0045087

innate immune response

IMP: Inferred from Mutant Phenotype

WB:WBVar00251211

P

From WB


WB:hsf-1

GO:0050829

defense response to Gram-negative bacterium

IMP: Inferred from Mutant Phenotype

WB:WBVar00248994

P

From WB


WB:hsf-1

GO:0045087

innate immune response

IMP: Inferred from Mutant Phenotype

WB:WBVar00248994

P

From WB


WB:spp-1

GO:0045087

innate immune response

IGI: Inferred from Genetic Interaction

WB:WBGene00000912

P

From WB


WB:spp-1

GO:0045087

innate immune response

IGI: Inferred from Genetic Interaction

WB:WBGene00000898

P

From WB


WB:spp-1

GO:0045087

innate immune response

IGI: Inferred from Genetic Interaction

WB:WBGene00004055

P

From WB


WB:spp-1

GO:0050829

defense response to Gram-negative bacterium

IGI: Inferred from Genetic Interaction

WB:WBGene00000898

P

From WB


WB:spp-1

GO:0050829

defense response to Gram-negative bacterium

IGI: Inferred from Genetic Interaction

WB:WBGene00000912

P

From WB


WB:spp-1

GO:0050829

defense response to Gram-negative bacterium

IGI: Inferred from Genetic Interaction

WB:WBGene00004055

P

From WB


WB:Y55D5A.5b

GO:0010553

negative regulation of gene-specific transcription from RNA polymerase II promoter

IMP: Inferred from Mutant Phenotype

WB:WBVar00143949

P

From WB


WB:R13H8.1f

GO:0050829

defense response to Gram-negative bacterium

IMP: Inferred from Mutant Phenotype

WB:WBVar00088538
WB:WBVar00088974
WB:WBVar00089216
WB:WBVar00275574

P

From WB


WB:R13H8.1f

GO:0045087

innate immune response

IMP: Inferred from Mutant Phenotype

WB:WBVar00088538
WB:WBVar00088974
WB:WBVar00089216
WB:WBVar00275574

P

From WB


WB:R13H8.1f

GO:0010552

positive regulation of gene-specific transcription from RNA polymerase II promoter

IMP: Inferred from Mutant Phenotype

WB:WBVar00089216

P

From WB


WB:R13H8.1f

GO:0005737

cytoplasm

IDA: Inferred from Direct Assay

C

From WB


WB:R13H8.1f

GO:0005634

nucleus

IDA: Inferred from Direct Assay

C

From WB


WB:T14E8.3d

GO:0010552

positive regulation of gene-specific transcription from RNA polymerase II promoter

IMP: Inferred from Mutant Phenotype

WB:WBVar00275094

P

From WB


CAEEL:FOXO

GO:0005634

nucleus

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

CAEEL:FOXO

GO:0005737

cytoplasm

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

CAEEL:FOXO

GO:0045087

innate immune response

IMP: Inferred from Mutant Phenotype

WB:WBVar00088538
WB:WBVar00088974
WB:WBVar00089216
WB:WBVar00275574

P

Seeded From UniProt

complete

CAEEL:FOXO

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IMP: Inferred from Mutant Phenotype

WB:WBVar00089216

P

Seeded From UniProt

complete

CAEEL:FOXO

GO:0050829

defense response to Gram-negative bacterium

IMP: Inferred from Mutant Phenotype

WB:WBVar00088538
WB:WBVar00088974
WB:WBVar00089216
WB:WBVar00275574

P

Seeded From UniProt

complete

CAEEL:PMK1

GO:0045087

innate immune response

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

Seeded From UniProt

complete

CAEEL:PMK1

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

Seeded From UniProt

complete

CAEEL:PMK1

GO:0050829

defense response to Gram-negative bacterium

IMP: Inferred from Mutant Phenotype

WB:WBVar00088252

P

Seeded From UniProt

complete


See also

References

See Help:References for how to manage references in GONUTS.