PMID:17888400

Citation	Kurz, CL, Shapira, M, Chen, K, Baillie, DL and Tan, MW (2007) Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade. Biochem. Biophys. Res. Commun. 363:438-43
Abstract	Animals and plants respond to bacterial infections and environmental stresses by inducing overlapping repertoires of defense genes. How the signals associated with infection and abiotic stresses are differentially integrated within a whole organism remains to be fully addressed. We show that the transcription of a Caenorhabditis elegans ABC transporter, pgp-5 is induced by both bacterial infection and heavy metal stress, but the magnitude and tissue distribution of its expression differs, depending on the type of stressor. PGP-5 contributes to resistance to bacterial infection and heavy metals. Using pgp-5 transcription as a read-out, we show that signals from both biotic and abiotic stresses are integrated by TIR-1, a TIR domain adaptor protein orthologous to human SARM, and a p38 MAP kinase signaling cassette. We further demonstrate that not all the TIR-1 isoforms are necessary for nematode resistance to infection, suggesting a molecular basis for the differential response to abiotic and biotic stress.
Links	PubMed PMC2276653 Online version:10.1016/j.bbrc.2007.08.190
Keywords	Animals; Caenorhabditis elegans/drug effects; Caenorhabditis elegans/immunology; Caenorhabditis elegans Proteins/immunology; Cytoskeletal Proteins/immunology; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Immunity, Innate/immunology; Metals, Heavy/pharmacology; P-Glycoprotein/immunology; Protozoan Proteins/immunology; Pseudomonas Infections/immunology; Receptors, G-Protein-Coupled; p38 Mitogen-Activated Protein Kinases/immunology
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
CAEEL:SEK1	involved_in	GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium	ECO:0000315: mutant phenotype evidence used in manual assertion		P	has_input:(WB:WBGene00003999)	Seeded From UniProt	complete
CAEEL:PGP3	involved_in	GO:1990170: stress response to cadmium ion	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
CAEEL:PMK1	involved_in	GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium	ECO:0000315: mutant phenotype evidence used in manual assertion		P	has_input:(WB:WBGene00003999)	Seeded From UniProt	complete
CAEEL:Q17645	involved_in	GO:0050830: defense response to Gram-positive bacterium	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
CAEEL:Q17645	involved_in	GO:0050830: defense response to Gram-positive bacterium	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00092131	P		Seeded From UniProt	complete
CAEEL:Q17645	involved_in	GO:0050829: defense response to Gram-negative bacterium	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
CAEEL:Q17645	involved_in	GO:0050829: defense response to Gram-negative bacterium	ECO:0000315: mutant phenotype evidence used in manual assertion	WB:WBVar00092131	P		Seeded From UniProt	complete
CAEEL:Q17645	involved_in	GO:0042493: response to drug	ECO:0000270: expression pattern evidence used in manual assertion		P	has_input:(CHEBI:23359)	Seeded From UniProt	complete
CAEEL:Q17645	involved_in	GO:1990170: stress response to cadmium ion	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
CAEEL:Q17645	involved_in	GO:1990170: stress response to cadmium ion	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
CAEEL:Q17645	involved_in	GO:1990169: stress response to copper ion	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
CAEEL:Q17645	involved_in	GO:1990169: stress response to copper ion	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
CAEEL:Q20331	involved_in	GO:1990170: stress response to cadmium ion	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
CAEEL:NSY1	involved_in	GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium	ECO:0000315: mutant phenotype evidence used in manual assertion		P	has_input:(WB:WBGene00003999)	Seeded From UniProt	complete
CAEEL:Q22655	involved_in	GO:1990170: stress response to cadmium ion	ECO:0000270: expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
CAEEL:SARM1	involved_in	GO:0045944: positive regulation of transcription by RNA polymerase II	ECO:0000315: mutant phenotype evidence used in manual assertion		P	has_input:(WB:WBGene00003999) occurs_in:(WBbt:0003681)	Seeded From UniProt	complete
CAEEL:SARM1	involved_in	GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium	ECO:0000315: mutant phenotype evidence used in manual assertion		P	has_input:(WB:WBGene00003999)	Seeded From UniProt	complete
CAEEL:PMK1	involved_in	GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium	ECO:0000315: mutant phenotype evidence used in manual assertion		P	has_regulation_target:(WB:WBGene00003999)	Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.