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PMID:17888400

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Citation

Kurz, CL, Shapira, M, Chen, K, Baillie, DL and Tan, MW (2007) Caenorhabditis elegans pgp-5 is involved in resistance to bacterial infection and heavy metal and its regulation requires TIR-1 and a p38 map kinase cascade. Biochem. Biophys. Res. Commun. 363:438-43

Abstract

Animals and plants respond to bacterial infections and environmental stresses by inducing overlapping repertoires of defense genes. How the signals associated with infection and abiotic stresses are differentially integrated within a whole organism remains to be fully addressed. We show that the transcription of a Caenorhabditis elegans ABC transporter, pgp-5 is induced by both bacterial infection and heavy metal stress, but the magnitude and tissue distribution of its expression differs, depending on the type of stressor. PGP-5 contributes to resistance to bacterial infection and heavy metals. Using pgp-5 transcription as a read-out, we show that signals from both biotic and abiotic stresses are integrated by TIR-1, a TIR domain adaptor protein orthologous to human SARM, and a p38 MAP kinase signaling cassette. We further demonstrate that not all the TIR-1 isoforms are necessary for nematode resistance to infection, suggesting a molecular basis for the differential response to abiotic and biotic stress.

Links

PubMed PMC2276653 Online version:10.1016/j.bbrc.2007.08.190

Keywords

Animals; Caenorhabditis elegans/drug effects; Caenorhabditis elegans/immunology; Caenorhabditis elegans Proteins/immunology; Cytoskeletal Proteins/immunology; Gene Expression Regulation/drug effects; Gene Expression Regulation/physiology; Immunity, Innate/immunology; Metals, Heavy/pharmacology; P-Glycoprotein/immunology; Protozoan Proteins/immunology; Pseudomonas Infections/immunology; Receptors, G-Protein-Coupled; p38 Mitogen-Activated Protein Kinases/immunology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

CAEEL:SEK1

involved_in

GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_input:(WB:WBGene00003999)

Seeded From UniProt

complete

CAEEL:PGP3

involved_in

GO:1990170: stress response to cadmium ion

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:PMK1

involved_in

GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_input:(WB:WBGene00003999)

Seeded From UniProt

complete

CAEEL:Q17645

involved_in

GO:0050830: defense response to Gram-positive bacterium

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:Q17645

involved_in

GO:0050830: defense response to Gram-positive bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00092131

P

Seeded From UniProt

complete

CAEEL:Q17645

involved_in

GO:0050829: defense response to Gram-negative bacterium

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:Q17645

involved_in

GO:0050829: defense response to Gram-negative bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

WB:WBVar00092131

P

Seeded From UniProt

complete

CAEEL:Q17645

involved_in

GO:0042493: response to drug

ECO:0000270: expression pattern evidence used in manual assertion

P

  • has_input:(CHEBI:23359)

Seeded From UniProt

complete

CAEEL:Q17645

involved_in

GO:1990170: stress response to cadmium ion

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:Q17645

involved_in

GO:1990170: stress response to cadmium ion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:Q17645

involved_in

GO:1990169: stress response to copper ion

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:Q17645

involved_in

GO:1990169: stress response to copper ion

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:Q20331

involved_in

GO:1990170: stress response to cadmium ion

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:NSY1

involved_in

GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_input:(WB:WBGene00003999)

Seeded From UniProt

complete

CAEEL:Q22655

involved_in

GO:1990170: stress response to cadmium ion

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete

CAEEL:SARM1

involved_in

GO:0045944: positive regulation of transcription by RNA polymerase II

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_input:(WB:WBGene00003999)
  • occurs_in:(WBbt:0003681)

Seeded From UniProt

complete

CAEEL:SARM1

involved_in

GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

  • has_input:(WB:WBGene00003999)

Seeded From UniProt

complete

CAEEL:PMK1

involved_in

GO:1902097: positive regulation of transcription from RNA polymerase II promoter involved in defense response to Gram-negative bacterium

ECO:0000315: mutant phenotype evidence used in manual assertion

P

has_regulation_target:(WB:WBGene00003999)

Seeded From UniProt

complete

Notes

See also

References

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