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Pujol, N, Cypowyj, S, Ziegler, K, Millet, A, Astrain, A, Goncharov, A, Jin, Y, Chisholm, AD and Ewbank, JJ (2008) Distinct innate immune responses to infection and wounding in the C. elegans epidermis. Curr. Biol. 18:481-9
In many animals, the epidermis is in permanent contact with the environment and represents a first line of defense against pathogens and injury. Infection of the nematode Caenorhabditis elegans by the natural fungal pathogen Drechmeria coniospora induces the expression in the epidermis of antimicrobial peptide (AMP) genes such as nlp-29. Here, we tested the hypothesis that injury might also alter AMP gene expression and sought to characterize the mechanisms that regulate the innate immune response.
Amino Acid Sequence; Animals; Antimicrobial Cationic Peptides/genetics; Antimicrobial Cationic Peptides/metabolism; Caenorhabditis elegans/genetics; Caenorhabditis elegans/immunology; Caenorhabditis elegans/metabolism; Caenorhabditis elegans Proteins/metabolism; Epidermis/immunology; Immunity, Innate/physiology; Infection/immunology; Infection/metabolism; Molecular Sequence Data; Neuropeptides/metabolism; Protein Kinases/metabolism; Signal Transduction/physiology; Up-Regulation; Wound Healing/physiology; p38 Mitogen-Activated Protein Kinases/metabolism
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