User:Mcalisterj

My Annotations

Status	Page	Date/Time	GO Term (Aspect)	Reference	Evidence	Notes	Links
requireschanges	HHV1F:GB	2013-02-09 15:52:10 CST	GO:0055036 virion membrane (C)	PMID:255182	ECO:0000314 direct assay evidence used in manual assertion	The gB-1 polypeptide is protected from proteolysis by the membrane of the virion. This is due, in part, to a short COOH-terminal cytoplasmic tail that can be observed in figure 7. The discussion located below figure 7 discusses this characteristic in further detail.	challenge
updatedbyinstructor	HCMVM:GO	2013-02-10 16:56:48 CST	GO:0046597 negative regulation of viral entry into host cell (P)	PMID:21880752	ECO:0000315 mutant phenotype evidence used in manual assertion	The coexpression of gO with gH/gL substantially increases interference in human fibroblasts compared with gH/gL alone and that gH/gL/gO does not interfere in epithelial cells. Evidence for this claim is demonstrated in Figure 1.	challenge
updatedbyinstructor	HHV8P:MIR2	2013-03-26 19:35:58 CDT	GO:0039504 suppression by virus of host adaptive immune response (P)	PMID:23460925	ECO:0000315 mutant phenotype evidence used in manual assertion	See Figure 2. In the presence of wild-type K5, surface levels of MHC I were reduced about 80–90%. Figure 2 shows us that the levels of MHC 1 was greatly reduced with the addition of K5 and RING-CH mutated viral protein.	challenge
updatedbyinstructor	HHV8P:MIR1	2013-03-26 19:45:52 CDT	GO:0039504 suppression by virus of host adaptive immune response (P)	PMID:23460925	ECO:0000315 mutant phenotype evidence used in manual assertion	See Figure 2. In the presence of wild-type K3, surface levels of MHC I were reduced about 80–90%. Figure 2 shows us that the levels of MHC 1 was greatly reduced with the addition of K3 and RING-CH mutated viral protein.	challenge
updatedbyinstructor	HHV8P:MIR2	2013-03-26 20:24:29 CDT	GO:0075509 viral entry into host cell via endocytosis (P)	PMID:23460925	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4 demonstrates that Wild-Type K5 causes a decreased amount of endocytosis of DC-SIGNR, yet enhanced endocytosis of DC-SIGN.	challenge
updatedbyinstructor	HHV8P:MIR1	2013-03-26 20:30:27 CDT	GO:0075509 viral entry into host cell via endocytosis (P)	PMID:23460925	ECO:0000315 mutant phenotype evidence used in manual assertion	Figure 4 demonstrates that Wild-Type K3 causes a decreased amount of endocytosis of DC-SIGNR, yet enhanced endocytosis of DC-SIGN.	challenge
acceptable	HHV8P:MIR2	2013-03-26 20:40:44 CDT	GO:0006511 ubiquitin-dependent protein catabolic process (P)	PMID:23460925	ECO:0000314 direct assay evidence used in manual assertion	See Figure 7. DC-SIGN and DC-SIGNR are ubiquitylated and degraded in a proteasomal- and lysosomal-dependent pathway by K5. It was confirmed that DC-SIGN displayed ubiquitylation only in the presence of K5 with an intact RING-CH domain.	challenge
acceptable	HHV8P:MIR1	2013-03-26 20:42:22 CDT	GO:0006511 ubiquitin-dependent protein catabolic process (P)	PMID:23460925	ECO:0000314 direct assay evidence used in manual assertion	See Figure 7. DC-SIGN and DC-SIGNR are ubiquitylated and degraded in a proteasomal- and lysosomal-dependent pathway by K3. It was confirmed that DC-SIGN displayed ubiquitylation only in the presence of K3 with an intact RING-CH domain.	challenge

acceptable:2
unacceptable:0
requires_changes:1
flagged:0

Annotations challenged by Mcalisterj

Status	Author,Group	Page	GO Term (Aspect)	Reference	Evidence	Links	Page history
unacceptable	Rjackson3, Team Robots In Disguise	HUMAN:CFTR	GO:0030324 - lung development (P)	PMID:23226399	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 2
acceptable	Kgreene, Team Science Dance	HUMAN:NEK8	GO:0005929 - cilium (C)	PMID:18199800	ECO:0000315 mutant phenotype evidence used in manual assertion	challenge	C: 3
acceptable	Hibbsder, Team KEGGstands at PubMed	STRTR:CAS3	GO:0004536 - DNA nuclease activity (F)	PMID:21343909	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 17
updatedbyinstructor	Deradeza, Team Team TATAboxxx	EBVB9:BALF1	GO:0043066 - negative regulation of apoptotic process (P)	PMID:22230317	ECO:0000314 direct assay evidence used in manual assertion	challenge	C: 1 fixed by Mcalisterj

1 annotations fixed by Mcalisterj

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