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fig4. C and D show that H4K16 acetylation is greatly increased in Hdac-/- knockouts compared to wild type in mouse oocytes. fig4.C shows Immunocytochemical detection of HDAC1 and histone H4K16 acetylation, and fig4.D shows the quantification of the data from C.

figure 2 show that p53 increases GLS2 transcription from 2 p53 inducible cell lines. After p53 had been induced, the levels of GLS2 mRNA increased by 35 fold in one line and 14 fold in the other as measured by real-time-PCR

Fig1.A shows that the staining intensity of HDAC1 are inversely proportional to that of acetylated H4K5 during oocyte maturation and reimplementation development. Fig7.A shows RNAi-mediated reduction of HDAC1 causing an increase for hyperacetylated histone H4.

figure 2 shows JARID1B removed H3K4 methylation in vivo. figure shows cell lines that have been with Myc-JARID1B, then immunostained with antibodies specific to methylated lysine residues. The top rows of A,B and C are those that are H3K4, and show cells are not visible in the red stain (the methylated lysine stain), compared to the other stain controls, indicating they have been demethylated.

Figure 2A shows that the use of AKT2 siRNA, causes a decrease in the transcriptional levels of Cdk2, while scrambled or uninhibited AKT2 allows for transcriptional up-regulation of Ckd2.

Measured through luciferase activity, Figure 3C clearly shows that transfection of c-Jun leads to nearly a 3 fold increase in the transcription of IL-11.

Measured by luciferase activity, Figure 3C, distinctly demonstrates that FRA-1 up-regulates the transcription of IL-11 over 3 fold.

Figure 2E, shows that following UV irradiation, E2F1 up-regulates the transcription of the p19 gene in the cell.

Figure 2A, shows that over a 36 hour period, FRA-2 causes greater than a 10 fold increase in ICOS mRNA levels, within mouse splenic CD4+ T cells.

According to Figure 3A, the TWIST protein binds to and transactivates the AKT2 promoter, leading to doasage-dependent increase in AKT2.

Figure 3 (A) shows the nuclease activity of Cas3 in the presence of MG2+ ions. Incubating Cas3 with M13mp18 ssDNA over a two hour period shows increased levels of Cas3 correspond to increased ssDNA degradation.