MOUSE:HDAC1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hdac1
Protein Name(s)	Histone deacetylase 1 HD1
External Links
UniProt	O09106
EMBL	X98207 U80780
CCDS	CCDS18696.1
RefSeq	NP_032254.1
UniGene	Mm.202504 Mm.391033
ProteinModelPortal	O09106
SMR	O09106
BioGrid	241423
DIP	DIP-31499N
IntAct	O09106
MINT	MINT-2568222
BindingDB	O09106
ChEMBL	CHEMBL4001
PhosphoSite	O09106
MaxQB	O09106
PaxDb	O09106
PRIDE	O09106
Ensembl	ENSMUST00000102597
GeneID	433759
KEGG	mmu:433759
UCSC	uc008uxg.1
CTD	3065
MGI	MGI:108086
eggNOG	COG0123
HOGENOM	HOG000225180
HOVERGEN	HBG057112
InParanoid	O09106
KO	K06067
OMA	LTQGTKR
OrthoDB	EOG7DNNTW
PhylomeDB	O09106
TreeFam	TF106171
Reactome	REACT_196464 REACT_196589 REACT_196591 REACT_198649 REACT_199110 REACT_200667 REACT_202086 REACT_214440 REACT_216539 REACT_219771 REACT_220566 REACT_233471 REACT_235780 REACT_257106
SABIO-RK	O09106
NextBio	408961
PRO	PR:O09106
Proteomes	UP000000589
Bgee	O09106
CleanEx	MM_HDAC1
ExpressionAtlas	O09106
Genevestigator	O09106
GO	GO:0005737 GO:0000792 GO:0000118 GO:0043025 GO:0000790 GO:0005634 GO:0016581 GO:0043234 GO:0005667 GO:0017053 GO:0003682 GO:0001047 GO:0019213 GO:0003677 GO:0004407 GO:0035851 GO:0032041 GO:0097372 GO:0046969 GO:0046970 GO:0001103 GO:0003700 GO:0003714 GO:0008134 GO:0000976 GO:0016568 GO:0032922 GO:0007623 GO:0042733 GO:0007492 GO:0009913 GO:0061029 GO:0061198 GO:0060789 GO:0021766 GO:0070932 GO:0070933 GO:0043066 GO:0090090 GO:0043124 GO:2001243 GO:0000122 GO:0045892 GO:0030182 GO:0042475 GO:0008284 GO:0048714 GO:0006351
Gene3D	3.40.800.20
InterPro	IPR000286 IPR003084 IPR023801
PANTHER	PTHR10625
Pfam	PF00850
PIRSF	PIRSF037913
PRINTS	PR01270 PR01271

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004407	histone deacetylase activity	PMID:18501342^[1]	ECO:0000314			F		Fig1.A shows that the staining intensity of HDAC1 are inversely proportional to that of acetylated H4K5 during oocyte maturation and reimplementation development. Fig7.A shows RNAi-mediated reduction of HDAC1 causing an increase for hyperacetylated histone H4.	complete CACAO 7818
enables	GO:0008134	transcription factor binding	PMID:18486321^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28033	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:21960634^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:21960634^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061198	fungiform papilla formation	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0061029	eyelid development in camera-type eye	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0060789	hair follicle placode formation	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0042733	embryonic digit morphogenesis	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0042475	odontogenesis of dentin-containing tooth	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0009913	epidermal cell differentiation	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21093383^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70288	P		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:15226430^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:15226430^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035851	Krueppel-associated box domain binding	PMID:21177534^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:E9QAG8	F		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:15226430^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	PMID:15226430^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007623	circadian rhythm	PMID:24736997^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17707228^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:10615135^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0070888	E-box binding	PMID:24736997^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:24413057^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	PMID:21680841^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 MGI:MGI:1343091 PANTHER:PTN002578320 PomBase:SPAC3G9.07c SGD:S000005274 SGD:S000006272 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 RGD:1309799 RGD:619976 RGD:619977 SGD:S000005274 TAIR:locus:2098115 UniProtKB:G5EB64 UniProtKB:Q13547	P		Seeded From UniProt	complete
part_of	GO:0070822	Sin3-type complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 PANTHER:PTN000066122 PomBase:SPBC36.05c SGD:S000005274 UniProtKB:Q13547 UniProtKB:Q92769	C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002578320 PomBase:SPBC36.05c SGD:S000005274 SGD:S000006272 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	P		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 FB:FBgn0025825 MGI:MGI:108086 MGI:MGI:1097691 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c RGD:1309799 SGD:S000003162 SGD:S000005274 TAIR:locus:2162017 UniProtKB:G5EB64 UniProtKB:O15379 UniProtKB:Q13547 UniProtKB:Q7K6A1 UniProtKB:Q92769 WB:WBGene00001834 dictyBase:DDB_G0270338	F		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:21873635^[12]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015805 MGI:MGI:108086 PANTHER:PTN002578320 PomBase:SPAC3G9.07c PomBase:SPBC36.05c SGD:S000003162 SGD:S000005274 SGD:S000006272 UniProtKB:Q13547 UniProtKB:Q92769 WB:WBGene00001834	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21093383^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1097691	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000757	negative regulation of peptidyl-lysine acetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	PMID:22770845^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19503085^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1097691	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070933	histone H4 deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070932	histone H3 deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070932	histone H3 deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060766	negative regulation of androgen receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0052548	regulation of endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048714	positive regulation of oligodendrocyte differentiation	PMID:19503085^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1097691	P	occurs_in:(EMAPA:17544) regulates_o_results_in_acquisition_of_features_of:(CL:0000128)\|occurs_in(EMAPA:17577) regulates_o_results_in_acquisition_of_features_of:(CL:0000128)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	C		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	PMID:17150957^[15]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046676	negative regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:9271381^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	F		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043922	negative regulation by host of viral transcription	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	PMID:19805123^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:87859	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:18651664^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16470) part_of:(CL:0000681)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	C		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034599	cellular response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19796622^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032732	positive regulation of interleukin-1 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:19380719^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1097691	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021766	hippocampus development	PMID:19380719^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1097691	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	F		Seeded From UniProt	complete
part_of	GO:0017053	transcriptional repressor complex	PMID:17182846^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05627 UniProtKB:P70288 UniProtKB:Q60520 UniProtKB:Q60974 UniProtKB:Q9QYB2	C		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:16462733^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8K4B0 UniProtKB:Q9R190 UniProtKB:Q9Z2D8	C		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:14645126^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9R190	C		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:22075476^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17962) part_of:(CL:0000501)	Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	PMID:11836251^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	C		Seeded From UniProt	complete
part_of	GO:0016580	Sin3 complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016575	histone deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010870	positive regulation of receptor biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:15060137^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:15060137^[26]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006476	protein deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006346	methylation-dependent chromatin silencing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17182846^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05627 UniProtKB:P70288 UniProtKB:Q60520 UniProtKB:Q60974 UniProtKB:Q9QYB2	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22770845^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21874024^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20720167^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16039) part_of:(CL:0000007)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:8917507^[29]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:15509593^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17392792^[31]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:17905753^[32]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:97747)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16678101^[33]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16898) has_participant:(MGI:MGI:96071)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:16109736^[34]	ECO:0000314	direct assay evidence used in manual assertion		F	has_participant:(MGI:MGI:96928)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15608638^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:14593184^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001975	response to amphetamine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	P		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	PMID:19235719^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8BIA3	F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
enables	GO:0001046	core promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:14643676^[38]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16041) part_of:(CL:0000007)\|part_of:(EMAPA:16046) part_of:(CL:1000274)	Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:14519686^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1309799	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9271381^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:8917507^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13547	P		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:14645126^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q80TZ9	C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0070933	histone H4 deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
enables	GO:0070491	repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
involved_in	GO:0060766	negative regulation of androgen receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0052548	regulation of endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
involved_in	GO:0043922	negative regulation by host of viral transcription	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0033558	protein deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	C		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
part_of	GO:0016581	NuRD complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	C		Seeded From UniProt	complete
part_of	GO:0016580	Sin3 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	C		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0010870	positive regulation of receptor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
involved_in	GO:0006476	protein deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:0006346	methylation-dependent chromatin silencing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0001103	RNA polymerase II repressing transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0001046	core promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13547 ensembl:ENSP00000362649	P		Seeded From UniProt	complete
involved_in	GO:2000757	negative regulation of peptidyl-lysine acetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:2000676	positive regulation of type B pancreatic cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:2000343	positive regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0070932	histone H3 deacetylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0055093	response to hyperoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	C		Seeded From UniProt	complete
involved_in	GO:0046676	negative regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	C		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	C		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0032732	positive regulation of interleukin-1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0031000	response to caffeine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
enables	GO:0019213	deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	F		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	F		Seeded From UniProt	complete
involved_in	GO:0001975	response to amphetamine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	P		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4QQW4 ensembl:ENSRNOP00000012854	C		Seeded From UniProt	complete
enables	GO:0051059	NF-kappaB binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6IT96 ensembl:ENSP00000362649	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6IT96 ensembl:ENSP00000362649	C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	F		Seeded From UniProt	complete
involved_in	GO:0016575	histone deacetylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003084	P		Seeded From UniProt	complete
enables	GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:3.5.1.98	F		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	PMID:12711221^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:12711221^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12711221^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000118	histone deacetylase complex	PMID:12711221^[40]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-573385 Reactome:R-NUL-573373 Reactome:R-MMU-9625109 Reactome:R-MMU-9017958 Reactome:R-MMU-9006133 Reactome:R-MMU-8978989 Reactome:R-MMU-8978980 Reactome:R-MMU-8978970 Reactome:R-MMU-8978954 Reactome:R-MMU-573383 Reactome:R-MMU-573376 Reactome:R-MMU-573336	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004407	histone deacetylase activity	Reactome:R-MMU-573376	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ma, P & Schultz, RM (2008) Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. Dev. Biol. 319 110-20 PubMed GONUTS page
↑ Ceseña, TI et al. (2008) Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription. Mol. Cell. Endocrinol. 289 94-101 PubMed GONUTS page
↑ ^3.0 ^3.1 DiTacchio, L et al. (2011) Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science 333 1881-5 PubMed GONUTS page
↑ ^4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 LeBoeuf, M et al. (2010) Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev. Cell 19 807-18 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Naruse, Y et al. (2004) Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol. Cell. Biol. 24 6278-87 PubMed GONUTS page
↑ He, Z et al. (2011) A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. J. Biol. Chem. 286 7279-89 PubMed GONUTS page
↑ ^7.0 ^7.1 Goriki, A et al. (2014) A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 12 e1001839 PubMed GONUTS page
↑ Saleque, S et al. (2007) Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol. Cell 27 562-72 PubMed GONUTS page
↑ Fuks, F et al. (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat. Genet. 24 88-91 PubMed GONUTS page
↑ Duong, HA & Weitz, CJ (2014) Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat. Struct. Mol. Biol. 21 126-32 PubMed GONUTS page
↑ Duong, HA et al. (2011) A molecular mechanism for circadian clock negative feedback. Science 332 1436-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^13.0 ^13.1 Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page
↑ ^14.0 ^14.1 Ye, F et al. (2009) HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat. Neurosci. 12 829-38 PubMed GONUTS page
↑ Shen, Y et al. (2007) Functional architecture of atrophins. J. Biol. Chem. 282 5037-44 PubMed GONUTS page
↑ ^16.0 ^16.1 Bartl, S et al. (1997) Identification of mouse histone deacetylase 1 as a growth factor-inducible gene. Mol. Cell. Biol. 17 5033-43 PubMed GONUTS page
↑ Liberatore, RA et al. (2009) NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 106 17823-8 PubMed GONUTS page
↑ MacDonald, JL & Roskams, AJ (2008) Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development. Dev. Dyn. 237 2256-67 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page
↑ ^20.0 ^20.1 Montgomery, RL et al. (2009) Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc. Natl. Acad. Sci. U.S.A. 106 7876-81 PubMed GONUTS page
↑ ^21.0 ^21.1 Wu, K et al. (2007) Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol. Biol. Cell 18 755-67 PubMed GONUTS page
↑ Kaji, K et al. (2006) The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat. Cell Biol. 8 285-92 PubMed GONUTS page
↑ ^23.0 ^23.1 Zoltewicz, JS et al. (2004) Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. Development 131 3-14 PubMed GONUTS page
↑ Kwintkiewicz, J et al. (2012) Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells. Biol. Reprod. 86 1-8 PubMed GONUTS page
↑ Kiefer, SM et al. (2002) Murine Sall1 represses transcription by recruiting a histone deacetylase complex. J. Biol. Chem. 277 14869-76 PubMed GONUTS page
↑ ^26.0 ^26.1 Tou, L et al. (2004) Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol. Cell. Biol. 24 3132-9 PubMed GONUTS page
↑ Chang, M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat. Immunol. 12 1002-9 PubMed GONUTS page
↑ Ma, P et al. (2010) Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol. Reprod. 83 1027-35 PubMed GONUTS page
↑ ^29.0 ^29.1 Yang, WM et al. (1996) Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc. Natl. Acad. Sci. U.S.A. 93 12845-50 PubMed GONUTS page
↑ Barbacci, E et al. (2004) HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment. Hum. Mol. Genet. 13 3139-49 PubMed GONUTS page
↑ Wang, J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446 882-7 PubMed GONUTS page
↑ Pérez-Mancera, PA et al. (2007) Adipose tissue mass is modulated by SLUG (SNAI2). Hum. Mol. Genet. 16 2972-86 PubMed GONUTS page
↑ Olson, LE et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell 125 593-605 PubMed GONUTS page
↑ Winnay, JN & Hammer, GD (2006) Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Mol. Endocrinol. 20 147-66 PubMed GONUTS page
↑ Horike, S et al. (2005) Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat. Genet. 37 31-40 PubMed GONUTS page
↑ Martinowich, K et al. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302 890-3 PubMed GONUTS page
↑ Anderson, DM et al. (2009) The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex. Dev. Dyn. 238 572-80 PubMed GONUTS page
↑ Kantor, B et al. (2003) Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. Gene Expr. Patterns 3 697-702 PubMed GONUTS page
↑ Craig, JM et al. (2003) Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum. Mol. Genet. 12 3109-21 PubMed GONUTS page
↑ ^40.0 ^40.1 ^40.2 ^40.3 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page

[PMID:18501342-1] Ma, P & Schultz, RM (2008) Histone deacetylase 1 (HDAC1) regulates histone acetylation, development, and gene expression in preimplantation mouse embryos. Dev. Biol. 319 110-20 PubMed GONUTS page

[PMID:18486321-2] Ceseña, TI et al. (2008) Acetylation and deacetylation regulate CCAAT/enhancer binding protein beta at K39 in mediating gene transcription. Mol. Cell. Endocrinol. 289 94-101 PubMed GONUTS page

[PMID:21960634-3] 3.0 ^3.1 DiTacchio, L et al. (2011) Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock. Science 333 1881-5 PubMed GONUTS page

[PMID:21093383-4] 4.00 ^4.01 ^4.02 ^4.03 ^4.04 ^4.05 ^4.06 ^4.07 ^4.08 ^4.09 ^4.10 LeBoeuf, M et al. (2010) Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev. Cell 19 807-18 PubMed GONUTS page

[PMID:15226430-5] 5.0 ^5.1 ^5.2 ^5.3 Naruse, Y et al. (2004) Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol. Cell. Biol. 24 6278-87 PubMed GONUTS page

[PMID:21177534-6] He, Z et al. (2011) A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription. J. Biol. Chem. 286 7279-89 PubMed GONUTS page

[PMID:24736997-7] 7.0 ^7.1 Goriki, A et al. (2014) A novel protein, CHRONO, functions as a core component of the mammalian circadian clock. PLoS Biol. 12 e1001839 PubMed GONUTS page

[PMID:17707228-8] Saleque, S et al. (2007) Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol. Cell 27 562-72 PubMed GONUTS page

[PMID:10615135-9] Fuks, F et al. (2000) DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat. Genet. 24 88-91 PubMed GONUTS page

[PMID:24413057-10] Duong, HA & Weitz, CJ (2014) Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. Nat. Struct. Mol. Biol. 21 126-32 PubMed GONUTS page

[PMID:21680841-11] Duong, HA et al. (2011) A molecular mechanism for circadian clock negative feedback. Science 332 1436-9 PubMed GONUTS page

[PMID:21873635-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22770845-13] 13.0 ^13.1 Qin, J et al. (2012) The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell 11 319-32 PubMed GONUTS page

[PMID:19503085-14] 14.0 ^14.1 Ye, F et al. (2009) HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interaction. Nat. Neurosci. 12 829-38 PubMed GONUTS page

[PMID:17150957-15] Shen, Y et al. (2007) Functional architecture of atrophins. J. Biol. Chem. 282 5037-44 PubMed GONUTS page

[PMID:9271381-16] 16.0 ^16.1 Bartl, S et al. (1997) Identification of mouse histone deacetylase 1 as a growth factor-inducible gene. Mol. Cell. Biol. 17 5033-43 PubMed GONUTS page

[PMID:19805123-17] Liberatore, RA et al. (2009) NF-kappaB activity is constitutively elevated in c-Abl null fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 106 17823-8 PubMed GONUTS page

[PMID:18651664-18] MacDonald, JL & Roskams, AJ (2008) Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development. Dev. Dyn. 237 2256-67 PubMed GONUTS page

[PMID:19796622-19] Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:19380719-20] 20.0 ^20.1 Montgomery, RL et al. (2009) Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development. Proc. Natl. Acad. Sci. U.S.A. 106 7876-81 PubMed GONUTS page

[PMID:17182846-21] 21.0 ^21.1 Wu, K et al. (2007) Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth. Mol. Biol. Cell 18 755-67 PubMed GONUTS page

[PMID:16462733-22] Kaji, K et al. (2006) The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Nat. Cell Biol. 8 285-92 PubMed GONUTS page

[PMID:14645126-23] 23.0 ^23.1 Zoltewicz, JS et al. (2004) Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis. Development 131 3-14 PubMed GONUTS page

[PMID:22075476-24] Kwintkiewicz, J et al. (2012) Metastasis-associated protein 3 (MTA3) regulates G2/M progression in proliferating mouse granulosa cells. Biol. Reprod. 86 1-8 PubMed GONUTS page

[PMID:11836251-25] Kiefer, SM et al. (2002) Murine Sall1 represses transcription by recruiting a histone deacetylase complex. J. Biol. Chem. 277 14869-76 PubMed GONUTS page

[PMID:15060137-26] 26.0 ^26.1 Tou, L et al. (2004) Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases. Mol. Cell. Biol. 24 3132-9 PubMed GONUTS page

[PMID:21874024-27] Chang, M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat. Immunol. 12 1002-9 PubMed GONUTS page

[PMID:20720167-28] Ma, P et al. (2010) Metastasis tumor antigen 2 (MTA2) is involved in proper imprinted expression of H19 and Peg3 during mouse preimplantation development. Biol. Reprod. 83 1027-35 PubMed GONUTS page

[PMID:8917507-29] 29.0 ^29.1 Yang, WM et al. (1996) Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc. Natl. Acad. Sci. U.S.A. 93 12845-50 PubMed GONUTS page

[PMID:15509593-30] Barbacci, E et al. (2004) HNF1beta/TCF2 mutations impair transactivation potential through altered co-regulator recruitment. Hum. Mol. Genet. 13 3139-49 PubMed GONUTS page

[PMID:17392792-31] Wang, J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446 882-7 PubMed GONUTS page

[PMID:17905753-32] Pérez-Mancera, PA et al. (2007) Adipose tissue mass is modulated by SLUG (SNAI2). Hum. Mol. Genet. 16 2972-86 PubMed GONUTS page

[PMID:16678101-33] Olson, LE et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell 125 593-605 PubMed GONUTS page

[PMID:16109736-34] Winnay, JN & Hammer, GD (2006) Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Mol. Endocrinol. 20 147-66 PubMed GONUTS page

[PMID:15608638-35] Horike, S et al. (2005) Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat. Genet. 37 31-40 PubMed GONUTS page

[PMID:14593184-36] Martinowich, K et al. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302 890-3 PubMed GONUTS page

[PMID:19235719-37] Anderson, DM et al. (2009) The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex. Dev. Dyn. 238 572-80 PubMed GONUTS page

[PMID:14643676-38] Kantor, B et al. (2003) Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. Gene Expr. Patterns 3 697-702 PubMed GONUTS page

[PMID:14519686-39] Craig, JM et al. (2003) Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum. Mol. Genet. 12 3109-21 PubMed GONUTS page

[PMID:12711221-40] 40.0 ^40.1 ^40.2 ^40.3 Verdin, E et al. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19 286-93 PubMed GONUTS page

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