HUMAN:E2F1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	E2F1 (synonyms: RBBP3)
Protein Name(s)	Transcription factor E2F1 E2F-1 PBR3 Retinoblastoma-associated protein 1 RBAP-1 Retinoblastoma-binding protein 3 RBBP-3 pRB-binding protein E2F-1
External Links
UniProt	Q01094
EMBL	M96577 U47677 U47675 U47676 S49592 AF516106 AL121906 BC050369 BC058902 S74230
CCDS	CCDS13224.1
PIR	JC4929
RefSeq	NP_005216.1
UniGene	Hs.654393
PDB	1H24 1O9K 2AZE
PDBsum	1H24 1O9K 2AZE
ProteinModelPortal	Q01094
SMR	Q01094
BioGrid	108201
DIP	DIP-24227N
IntAct	Q01094
MINT	MINT-112765
STRING	9606.ENSP00000345571
ChEMBL	CHEMBL4382
PhosphoSite	Q01094
DMDM	400928
MaxQB	Q01094
PaxDb	Q01094
PRIDE	Q01094
Ensembl	ENST00000343380 ENST00000622594
GeneID	1869
KEGG	hsa:1869
UCSC	uc002wzu.4
CTD	1869
GeneCards	GC20M032263
HGNC	HGNC:3113
HPA	CAB000329 CAB019308 HPA008003
MIM	189971
neXtProt	NX_Q01094
PharmGKB	PA152
eggNOG	NOG328718
GeneTree	ENSGT00550000074403
HOGENOM	HOG000232045
HOVERGEN	HBG002227
InParanoid	Q01094
KO	K17454
OMA	RHPGKGV
OrthoDB	EOG738058
PhylomeDB	Q01094
TreeFam	TF105566
Reactome	REACT_111214 REACT_1181 REACT_118568 REACT_1194 REACT_121 REACT_169325 REACT_169436 REACT_1707 REACT_1915 REACT_329 REACT_471 REACT_683 REACT_821
SignaLink	Q01094
ChiTaRS	E2F1
EvolutionaryTrace	Q01094
GeneWiki	E2F1
GenomeRNAi	1869
NextBio	7643
PRO	PR:Q01094
Proteomes	UP000005640
Bgee	Q01094
CleanEx	HS_E2F1
Genevestigator	Q01094
GO	GO:0005737 GO:0005654 GO:0005634 GO:0035189 GO:0001047 GO:0003677 GO:0043565 GO:0003700 GO:0008134 GO:0043276 GO:0006915 GO:0071398 GO:0071456 GO:0000077 GO:0030900 GO:0000082 GO:0097193 GO:0072332 GO:0008630 GO:1990086 GO:0000278 GO:0048255 GO:0000122 GO:0071930 GO:0045892 GO:0007219 GO:0048146 GO:0010628 GO:1900740 GO:0045944 GO:0045893 GO:2000045 GO:0006355 GO:0007283 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR015633 IPR003316 IPR011991
PANTHER	PTHR12081
Pfam	PF02319

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:22476863^[1]	ECO:0000314			P		Figure 2E, shows that following UV irradiation, E2F1 up-regulates the transcription of the p19 gene in the cell.	complete CACAO 7603
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:A0A0G2JXE8 UniProtKB:A0A0G2JXN0 UniProtKB:D4ACR8 UniProtKB:F1Q0Q6 UniProtKB:F1Q0W2 UniProtKB:F6U0I3 UniProtKB:F6X5K4 UniProtKB:F6ZPV4 UniProtKB:F7A3K9 UniProtKB:F7A997 UniProtKB:F7ED92 UniProtKB:F7FYS0 UniProtKB:F7HDM2 UniProtKB:H2R4J2 UniProtKB:M3VZP2 UniProtKB:M3W3Z8 UniProtKB:O54917 UniProtKB:Q08639 UniProtKB:Q17QZ4 UniProtKB:Q32KX6	F		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:23629655^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR003316 InterPro:IPR015633	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:15565177^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q6IC98)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:20040599^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20040599^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	GO_REF:0000036	ECO:0000305	curator inference used in manual assertion	GO:0000122,GO:0043565	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:23332764^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:15565177^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20040599^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:21454377^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000105173)	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21454377^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	coincident_with:(SO:0000167) coincident_with:(ENSEMBL:ENSG00000231607)\|coincident_with:(SO:0000167) coincident_with:(ENSEMBL:ENSG00000113810)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:22476863^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070345	negative regulation of fat cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61501	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20176812^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	PMID:20176812^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20176812^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05554	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61501	F		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61501	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61501	P		Seeded From UniProt	complete
involved_in	GO:2000045	regulation of G1/S transition of mitotic cell cycle	PMID:20224733^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle	PMID:20224733^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048255	mRNA stabilization	PMID:15766563^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:20224733^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20224733^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20224733^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20224733^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035189	Rb-E2F complex	PMID:20224733^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:15766563^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:20224733^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:12717439^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:16360038^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q14186	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:12717439^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12717439^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15731768^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	has_regulation_target:(UniProtKB:P13640)	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:11418595^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15731768^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000987	proximal promoter sequence-specific DNA binding	PMID:15735762^[15]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	PMID:12717439^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0090575	RNA polymerase II transcription factor complex	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000249624 UniProtKB:O00716 UniProtKB:O75461 UniProtKB:Q14209	C		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011766 MGI:MGI:101941 MGI:MGI:1096341 PANTHER:PTN000249624	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011766 MGI:MGI:101941 MGI:MGI:103012 PANTHER:PTN000249624 UniProtKB:A0AVK6 UniProtKB:O00716 UniProtKB:Q01094 UniProtKB:Q14209 UniProtKB:Q16254 UniProtKB:Q96AV8 ZFIN:ZDB-GENE-030131-3527	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011766 MGI:MGI:101941 PANTHER:PTN000249624 RGD:621357 RGD:728892 UniProtKB:O00716 UniProtKB:Q01094 UniProtKB:Q14209 UniProtKB:Q9FV70	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011766 FB:FBgn0024371 MGI:MGI:101941 PANTHER:PTN000249624 UniProtKB:Q01094 UniProtKB:Q14209 UniProtKB:Q15329 UniProtKB:Q16254 WB:WBGene00001161	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011766 MGI:MGI:101941 MGI:MGI:103012 MGI:MGI:105091 MGI:MGI:1096341 MGI:MGI:1289147 MGI:MGI:1922038 PANTHER:PTN000249624 RGD:621357 RGD:728892 TAIR:locus:2100272 TAIR:locus:2100444 TAIR:locus:2147865 TAIR:locus:3685148 UniProtKB:A0AVK6 UniProtKB:O75461 UniProtKB:Q01094 UniProtKB:Q15329 UniProtKB:Q9FV70	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011766 MGI:MGI:101941 MGI:MGI:103012 MGI:MGI:105091 MGI:MGI:1096340 MGI:MGI:1096341 MGI:MGI:1289147 MGI:MGI:1354159 MGI:MGI:1922038 PANTHER:PTN000249624 TAIR:locus:3685148 UniProtKB:A0AVK6 UniProtKB:Q01094 UniProtKB:Q16254 UniProtKB:Q96AV8 UniProtKB:Q9FV70	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011766 MGI:MGI:103012 MGI:MGI:1096340 MGI:MGI:1354159 MGI:MGI:1922038 PANTHER:PTN000249624 TAIR:locus:2100272 TAIR:locus:2100444 TAIR:locus:2147865 TAIR:locus:3685148 UniProtKB:Q01094 UniProtKB:Q16254 UniProtKB:Q9FNY0 UniProtKB:Q9FV70	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011766 PANTHER:PTN000249624 UniProtKB:Q01094	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0011766 FB:FBgn0024371 MGI:MGI:1289147 MGI:MGI:1922038 PANTHER:PTN000249624 UniProtKB:A0AVK6 UniProtKB:O75461 UniProtKB:Q01094 UniProtKB:Q96AV8	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15073182^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1900740	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1900740	C		Seeded From UniProt	complete
involved_in	GO:1990090	cellular response to nerve growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09139 ensembl:ENSRNOP00000022428	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09139 ensembl:ENSRNOP00000022428	P		Seeded From UniProt	complete
involved_in	GO:0071398	cellular response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09139 ensembl:ENSRNOP00000022428	P		Seeded From UniProt	complete
involved_in	GO:0060252	positive regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09139 ensembl:ENSRNOP00000022428	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09139 ensembl:ENSRNOP00000022428	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09139 ensembl:ENSRNOP00000022428	F		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09139 ensembl:ENSRNOP00000022428	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09139 ensembl:ENSRNOP00000022428	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O09139 ensembl:ENSRNOP00000022428	C		Seeded From UniProt	complete
involved_in	GO:1990086	lens fiber cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
involved_in	GO:0071466	cellular response to xenobiotic stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
involved_in	GO:0070345	negative regulation of fat cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
involved_in	GO:0045599	negative regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	F		Seeded From UniProt	complete
involved_in	GO:0043276	anoikis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
involved_in	GO:0030900	forebrain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
involved_in	GO:0006351	transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61501 ensembl:ENSMUSP00000099434	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003316	F		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003316	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003316	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR032198	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11418595^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-139915 Reactome:R-HSA-111448	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070317	negative regulation of G0 to G1 transition	Reactome:R-HSA-8953750	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Reactome:R-HSA-6791312	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-8963657 Reactome:R-HSA-9018017 Reactome:R-HSA-9007561 Reactome:R-HSA-9007514 Reactome:R-HSA-8961961 Reactome:R-HSA-8961946 Reactome:R-HSA-8961920 Reactome:R-HSA-8961907 Reactome:R-HSA-8961888 Reactome:R-HSA-8961863 Reactome:R-HSA-8961840 Reactome:R-HSA-8961688 Reactome:R-HSA-8961671 Reactome:R-HSA-8961651 Reactome:R-HSA-8961636 Reactome:R-HSA-8961620 Reactome:R-HSA-8953556 Reactome:R-HSA-6798353 Reactome:R-HSA-4395231 Reactome:R-HSA-4331327 Reactome:R-HSA-4331324 Reactome:R-HSA-3240777 Reactome:R-HSA-3240766 Reactome:R-HSA-3240765 Reactome:R-HSA-3209096 Reactome:R-HSA-187959 Reactome:R-HSA-187937	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	Reactome:R-HSA-69205	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Carcagno, AL et al. (2012) E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation. Mol. Cell. Biochem. 366 123-9 PubMed GONUTS page
↑ Zhou, P et al. (2013) Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J. Biol. Chem. 288 17532-43 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^4.0 ^4.1 Stanelle, J et al. (2005) A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. Cell Death Differ. 12 347-57 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Paik, JC et al. (2010) Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. J. Biol. Chem. 285 6348-63 PubMed GONUTS page
↑ Jolma, A et al. (2013) DNA-binding specificities of human transcription factors. Cell 152 327-39 PubMed GONUTS page
↑ ^7.0 ^7.1 Ofir, M et al. (2011) MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E. Mol. Cancer Res. 9 440-7 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Zaragoza, K et al. (2010) Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol. Cell. Biol. 30 2293-304 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Sahin, F & Sladek, TL (2010) E2F-1 has dual roles depending on the cell cycle. Int. J. Biol. Sci. 6 116-28 PubMed GONUTS page
↑ ^10.0 ^10.1 Hughes, TA & Brady, HJ (2005) E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation. Biochem. Biophys. Res. Commun. 329 1267-74 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Stevens, C et al. (2003) Chk2 activates E2F-1 in response to DNA damage. Nat. Cell Biol. 5 401-9 PubMed GONUTS page
↑ Rubin, SM et al. (2005) Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123 1093-106 PubMed GONUTS page
↑ ^13.0 ^13.1 Fogal, V et al. (2005) ASPP1 and ASPP2 are new transcriptional targets of E2F. Cell Death Differ. 12 369-76 PubMed GONUTS page
↑ ^14.0 ^14.1 Lang, SE et al. (2001) E2F transcriptional activation requires TRRAP and GCN5 cofactors. J. Biol. Chem. 276 32627-34 PubMed GONUTS page
↑ Joshi, B et al. (2005) Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. Oncogene 24 2204-17 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Zhang, Y & Hamburger, AW (2004) Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription. J. Biol. Chem. 279 26126-33 PubMed GONUTS page

[PMID:22476863-1] 1.0 ^1.1 Carcagno, AL et al. (2012) E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation. Mol. Cell. Biochem. 366 123-9 PubMed GONUTS page

[PMID:23629655-2] Zhou, P et al. (2013) Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J. Biol. Chem. 288 17532-43 PubMed GONUTS page

[PMID:19274049-3] 3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:15565177-4] 4.0 ^4.1 Stanelle, J et al. (2005) A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. Cell Death Differ. 12 347-57 PubMed GONUTS page

[PMID:20040599-5] 5.0 ^5.1 ^5.2 Paik, JC et al. (2010) Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. J. Biol. Chem. 285 6348-63 PubMed GONUTS page

[PMID:23332764-6] Jolma, A et al. (2013) DNA-binding specificities of human transcription factors. Cell 152 327-39 PubMed GONUTS page

[PMID:21454377-7] 7.0 ^7.1 Ofir, M et al. (2011) MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E. Mol. Cancer Res. 9 440-7 PubMed GONUTS page

[PMID:20176812-8] 8.0 ^8.1 ^8.2 Zaragoza, K et al. (2010) Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol. Cell. Biol. 30 2293-304 PubMed GONUTS page

[PMID:20224733-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 ^9.6 ^9.7 Sahin, F & Sladek, TL (2010) E2F-1 has dual roles depending on the cell cycle. Int. J. Biol. Sci. 6 116-28 PubMed GONUTS page

[PMID:15766563-10] 10.0 ^10.1 Hughes, TA & Brady, HJ (2005) E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation. Biochem. Biophys. Res. Commun. 329 1267-74 PubMed GONUTS page

[PMID:12717439-11] 11.0 ^11.1 ^11.2 ^11.3 Stevens, C et al. (2003) Chk2 activates E2F-1 in response to DNA damage. Nat. Cell Biol. 5 401-9 PubMed GONUTS page

[PMID:16360038-12] Rubin, SM et al. (2005) Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell 123 1093-106 PubMed GONUTS page

[PMID:15731768-13] 13.0 ^13.1 Fogal, V et al. (2005) ASPP1 and ASPP2 are new transcriptional targets of E2F. Cell Death Differ. 12 369-76 PubMed GONUTS page

[PMID:11418595-14] 14.0 ^14.1 Lang, SE et al. (2001) E2F transcriptional activation requires TRRAP and GCN5 cofactors. J. Biol. Chem. 276 32627-34 PubMed GONUTS page

[PMID:15735762-15] Joshi, B et al. (2005) Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. Oncogene 24 2204-17 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 ^16.8 ^16.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:15073182-17] Zhang, Y & Hamburger, AW (2004) Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription. J. Biol. Chem. 279 26126-33 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

HUMAN:E2F1

Contents

Annotations

Notes

References

a

c

d

e

f

h

i

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools