HUMAN:AKT2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	AKT2
Protein Name(s)	RAC-beta serine/threonine-protein kinase Protein kinase Akt-2 Protein kinase B beta PKB beta RAC-PK-beta
External Links
UniProt	P31751
EMBL	M77198 M95936 AK314619 AC118344 BC032709 BC120995 BC120994 AY708392
CCDS	CCDS12552.1
PIR	A46288
RefSeq	NP_001617.1 XP_011524916.1 XP_011524917.1 XP_011524918.1 XP_011524919.1 XP_011524920.1 XP_011524921.1 XP_011524922.1 XP_011524923.1
UniGene	Hs.631535
PDB	1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D
PDBsum	1GZK 1GZN 1GZO 1MRV 1MRY 1O6K 1O6L 1P6S 2JDO 2JDR 2UW9 2X39 2XH5 3D0E 3E87 3E88 3E8D
DisProt	DP00304
ProteinModelPortal	P31751
SMR	P31751
BioGrid	106711
DIP	DIP-32583N
IntAct	P31751
MINT	MINT-87790
STRING	9606.ENSP00000375892
BindingDB	P31751
ChEMBL	CHEMBL2111353
GuidetoPHARMACOLOGY	1480
PhosphoSite	P31751
BioMuta	AKT2
DMDM	1170703
MaxQB	P31751
PaxDb	P31751
PRIDE	P31751
DNASU	208
Ensembl	ENST00000311278 ENST00000392038 ENST00000424901
GeneID	208
UCSC	uc002one.3 uc010egs.3
CTD	208
GeneCards	GC19M040736
HGNC	HGNC:392
HPA	CAB004204
MIM	125853 164731 240900
neXtProt	NX_P31751
Orphanet	79085 293964
PharmGKB	PA24685
eggNOG	COG0515
GeneTree	ENSGT00770000120449
HOGENOM	HOG000233033
HOVERGEN	HBG108317
InParanoid	P31751
OrthoDB	EOG7Q5HCW
PhylomeDB	P31751
TreeFam	TF102004
BRENDA	2.7.11.1
Reactome	REACT_115662 REACT_12442 REACT_12447 REACT_12564 REACT_13655 REACT_1451 REACT_147867 REACT_1695 REACT_19290 REACT_19358 REACT_19405 REACT_263991 REACT_264178 REACT_355377 REACT_355468 REACT_549 REACT_6743 REACT_75829 REACT_790
SignaLink	P31751
ChiTaRS	AKT2
EvolutionaryTrace	P31751
GeneWiki	AKT2
GenomeRNAi	208
NextBio	836
PRO	PR:P31751
Proteomes	UP000005640
Bgee	P31751
CleanEx	HS_AKT2
ExpressionAtlas	P31751
Genevisible	P31751
GO	GO:0005938 GO:0005829 GO:0032593 GO:0005654 GO:0005634 GO:0005886 GO:0032587 GO:0005524 GO:0016301 GO:0004674 GO:0090630 GO:0008643 GO:0006464 GO:0032869 GO:0071407 GO:0045444 GO:0006006 GO:0005978 GO:0008286 GO:0065002 GO:0060644 GO:0061024 GO:0043154 GO:0010748 GO:0033119 GO:0032287 GO:0030335 GO:2000147 GO:0032000 GO:0046326 GO:2001275 GO:0010907 GO:0045725 GO:0045429 GO:0033138 GO:0050927 GO:0001934 GO:0090314 GO:0009967 GO:0045944 GO:0031340 GO:0043491 GO:0072659 GO:0071156 GO:0030334 GO:0006417 GO:0014850 GO:0031667 GO:0006970 GO:0007165
Gene3D	2.30.29.30
InterPro	IPR000961 IPR011009 IPR011993 IPR001849 IPR017892 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00169 PF00069 PF00433
SMART	SM00233 SM00133 SM00220
SUPFAM	SSF56112
PROSITE	PS51285 PS50003 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0004674	protein serine/threonine kinase activity		ECO:0000304			F	Source: ProtInc	Missing: reference
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10983986^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010918	positive regulation of mitochondrial membrane potential	PMID:10983986^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:10983986^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:10983986^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
	GO:2000144	positive regulation of DNA-dependent transcription, initiation	PMID:21297943^[2]	ECO:0000314			P	Figure 2A shows that the use of AKT2 siRNA, causes a decrease in the transcriptional levels of Cdk2, while scrambled or uninhibited AKT2 allows for transcriptional up-regulation of Ckd2.	complete CACAO 7774
part_of	GO:0032991	protein-containing complex	PMID:10983986^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	PMID:25428377^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:2000147	positive regulation of cell motility	PMID:17332325^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	PMID:16814735^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045725	positive regulation of glycogen biosynthetic process	PMID:16814735^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:16814735^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032000	positive regulation of fatty acid beta-oxidation	PMID:16814735^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010907	positive regulation of glucose metabolic process	PMID:16814735^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0010748	negative regulation of long-chain fatty acid import across plasma membrane	PMID:16814735^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:16814735^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60823	P	Seeded From UniProt	complete
involved_in	GO:0065002	intracellular protein transmembrane transport	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60823	P	Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60823	C	Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60823	P	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60823	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60823	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20059950^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:16540465^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16540465^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q60823	P	Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003744 FB:FBgn0010379 MGI:MGI:97601 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAPB18E9.02c RGD:3395 RGD:3399 RGD:61925 RGD:620968 RGD:67383 SGD:S000000201 UniProtKB:O15530 UniProtKB:P31749 UniProtKB:Q15208 UniProtKB:Q9NRM7 UniProtKB:Q9Y2H1	P	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:87986 PANTHER:PTN000683254 RGD:2081 RGD:3395 RGD:3399 RGD:3668 RGD:61925 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000005460 UniProtKB:A0A1D5PUY5 UniProtKB:P31749 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q05513 UniProtKB:Q05655 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004033 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003091 FB:FBgn0003744 FB:FBgn0010379 FB:FBgn0260399 FB:FBgn0261854 MGI:MGI:104874 MGI:MGI:2182368 MGI:MGI:87986 MGI:MGI:894676 MGI:MGI:97595 MGI:MGI:97596 MGI:MGI:97599 MGI:MGI:97602 PANTHER:PTN000683254 PomBase:SPAC1B9.02c PomBase:SPAC22E12.14c PomBase:SPAC24B11.11c PomBase:SPAC821.12 PomBase:SPAPB18E9.02c PomBase:SPCC576.15c RGD:2081 RGD:2082 RGD:3399 RGD:3668 RGD:620146 RGD:620968 RGD:62390 SGD:S000001248 SGD:S000001609 SGD:S000001861 SGD:S000002898 SGD:S000003324 SGD:S000005105 SGD:S000005460 SGD:S000006315 TAIR:locus:2088515 UniProtKB:O15530 UniProtKB:O95835 UniProtKB:P05771 UniProtKB:P17252 UniProtKB:P31749 UniProtKB:P31751 UniProtKB:P41743 UniProtKB:Q02156 UniProtKB:Q04759 UniProtKB:Q05513 UniProtKB:Q05655 UniProtKB:Q09013 UniProtKB:Q15208 UniProtKB:Q16512 UniProtKB:Q16513 UniProtKB:Q96GX5 UniProtKB:Q9NRM7 UniProtKB:Q9XF67 UniProtKB:Q9Y243 UniProtKB:Q9Y2H1 WB:WBGene00000102 WB:WBGene00000103 WB:WBGene00004034 WB:WBGene00004789 WB:WBGene00006599 dictyBase:DDB_G0268620	F	Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0097473	retinal rod cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0090630	activation of GTPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0090314	positive regulation of protein targeting to membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0071486	cellular response to high light intensity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0065002	intracellular protein transmembrane transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0046326	positive regulation of glucose import	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
part_of	GO:0032587	ruffle membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	C	Seeded From UniProt	complete
involved_in	GO:0032287	peripheral nervous system myelin maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0031340	positive regulation of vesicle fusion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
part_of	GO:0005938	cell cortex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	C	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	F	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	F	Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q60823 ensembl:ENSMUSP00000103981	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000961 InterPro:IPR017892 InterPro:IPR034677 InterPro:IPR039027	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR017441 InterPro:IPR017892	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR000961 InterPro:IPR008271 InterPro:IPR017892 InterPro:IPR034677	P	Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR039027	P	Seeded From UniProt	complete
involved_in	GO:0006464	cellular protein modification process	PMID:1409633^[9]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:1409633^[9] PMID:21432781^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0071156	regulation of cell cycle arrest	PMID:21432781^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060644	mammary gland epithelial cell differentiation	PMID:21432781^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045444	fat cell differentiation	PMID:21432781^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0030334	regulation of cell migration	PMID:21432781^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21432781^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:21432781^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21432781^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21432781^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-165182 Reactome:R-HSA-165162 Reactome:R-HSA-109702 Reactome:R-HSA-109700	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-3769394	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
involved_in	GO:0005978	glycogen biosynthetic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0320	P	Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
involved_in	GO:0006006	glucose metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0313	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0321	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P	Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0008643	carbohydrate transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0762	P	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Laine, J et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6 395-407 PubMed GONUTS page
↑ Santi, SA & Lee, H (2011) Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells. PLoS ONE 6 e14614 PubMed GONUTS page
↑ Zhang, H et al. (2015) MicroRNA-29s could target AKT2 to inhibit gastric cancer cells invasion ability. Med. Oncol. 32 342 PubMed GONUTS page
↑ Cheng, GZ et al. (2007) Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res. 67 1979-87 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Bouzakri, K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 4 89-96 PubMed GONUTS page
↑ Suizu, F et al. (2009) The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev. Cell 17 800-10 PubMed GONUTS page
↑ ^7.0 ^7.1 Zhang, X et al. (2006) Kinetic mechanism of AKT/PKB enzyme family. J. Biol. Chem. 281 13949-56 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 Cheng, JQ et al. (1992) AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc. Natl. Acad. Sci. U.S.A. 89 9267-71 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Heron-Milhavet, L et al. (2011) Akt1 and Akt2: differentiating the aktion. Histol. Histopathol. 26 651-62 PubMed GONUTS page

[PMID:10983986-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 Laine, J et al. (2000) The protooncogene TCL1 is an Akt kinase coactivator. Mol. Cell 6 395-407 PubMed GONUTS page

[PMID:21297943-2] Santi, SA & Lee, H (2011) Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells. PLoS ONE 6 e14614 PubMed GONUTS page

[PMID:25428377-3] Zhang, H et al. (2015) MicroRNA-29s could target AKT2 to inhibit gastric cancer cells invasion ability. Med. Oncol. 32 342 PubMed GONUTS page

[PMID:17332325-4] Cheng, GZ et al. (2007) Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel. Cancer Res. 67 1979-87 PubMed GONUTS page

[PMID:16814735-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Bouzakri, K et al. (2006) siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metab. 4 89-96 PubMed GONUTS page

[PMID:20059950-6] Suizu, F et al. (2009) The E3 ligase TTC3 facilitates ubiquitination and degradation of phosphorylated Akt. Dev. Cell 17 800-10 PubMed GONUTS page

[PMID:16540465-7] 7.0 ^7.1 Zhang, X et al. (2006) Kinetic mechanism of AKT/PKB enzyme family. J. Biol. Chem. 281 13949-56 PubMed GONUTS page

[PMID:21873635-8] 8.0 ^8.1 ^8.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:1409633-9] 9.0 ^9.1 Cheng, JQ et al. (1992) AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc. Natl. Acad. Sci. U.S.A. 89 9267-71 PubMed GONUTS page

[PMID:21432781-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Heron-Milhavet, L et al. (2011) Akt1 and Akt2: differentiating the aktion. Histol. Histopathol. 26 651-62 PubMed GONUTS page

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