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PMID:1409633

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Citation

Cheng, JQ, Godwin, AK, Bellacosa, A, Taguchi, T, Franke, TF, Hamilton, TC, Tsichlis, PN and Testa, JR (1992) AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas. Proc. Natl. Acad. Sci. U.S.A. 89:9267-71

Abstract

We isolated cDNA clones containing the entire coding region of the putative oncogene AKT2. Sequence analysis and in vitro translation demonstrated that AKT2 encodes a 56-kDa protein with homology to serine/threonine kinases; moreover, this protein contains a Src homology 2-like domain. AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. AKT2 was mapped to chromosome region 19q13.1-q13.2 by fluorescence in situ hybridization. In the two ovarian carcinoma cell lines exhibiting amplification of AKT2, the amplified sequences were localized within homogeneously staining regions. We conclude that AKT2 belongs to a distinct subfamily of protein-serine/threonine kinases containing Src homology 2-like domains and that alterations of AKT2 may contribute to the pathogenesis of ovarian carcinomas.

Links

PubMed PMC50107

Keywords

Amino Acid Sequence; Chromosomes, Human/ultrastructure; Cloning, Molecular; DNA/genetics; DNA/isolation & purification; Female; Fluorescent Dyes; Gene Amplification; Gene Library; Humans; Lymphocytes/cytology; Molecular Sequence Data; Multigene Family; Oncogene Proteins/genetics; Oncogenes; Ovarian Neoplasms/enzymology; Ovarian Neoplasms/genetics; Protein Biosynthesis; Protein-Serine-Threonine Kinases/genetics; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sequence Homology, Amino Acid; Transcription, Genetic

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:AKT2

enables

GO:0004674: protein serine/threonine kinase activity

ECO:0000304: author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

HUMAN:AKT2

involved_in

GO:0006464: cellular protein modification process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:Q05BV0

involved_in

GO:0006464: cellular protein modification process

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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