HUMAN:FOSL1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FOSL1 (synonyms: FRA1)
Protein Name(s)	Fos-related antigen 1 FRA-1
External Links
UniProt	P15407
EMBL	X16707 AJ297411 AJ297412 AJ297413 AK299050 CR542257 CR542278 AP006287 CH471076 BC016648
CCDS	CCDS8121.1
PIR	S15750
RefSeq	NP_001287773.1 NP_001287784.1 NP_001287785.1 NP_001287786.1 NP_005429.1
UniGene	Hs.283565
ProteinModelPortal	P15407
SMR	P15407
BioGrid	113742
DIP	DIP-660N
IntAct	P15407
MINT	MINT-1445608
STRING	9606.ENSP00000310170
PhosphoSite	P15407
MaxQB	P15407
PaxDb	P15407
PRIDE	P15407
DNASU	8061
Ensembl	ENST00000312562 ENST00000448083
GeneID	8061
KEGG	hsa:8061
UCSC	uc001ogg.1 uc010ros.1
CTD	8061
GeneCards	GC11M065659
HGNC	HGNC:13718
HPA	CAB004396
MIM	136515
neXtProt	NX_P15407
PharmGKB	PA28214
eggNOG	NOG252534
GeneTree	ENSGT00730000110541
HOGENOM	HOG000234334
HOVERGEN	HBG005743
InParanoid	P15407
KO	K04502
OMA	PCEQISP
PhylomeDB	P15407
TreeFam	TF326301
ChiTaRS	FOSL1
GeneWiki	FOSL1
GenomeRNAi	8061
NextBio	30651
PRO	PR:P15407
Proteomes	UP000005640
Bgee	P15407
CleanEx	HS_FOSL1
ExpressionAtlas	P15407
Genevestigator	P15407
GO	GO:0005829 GO:0043005 GO:0005634 GO:0042734 GO:0000977 GO:0003700 GO:0006968 GO:0031668 GO:0006935 GO:0007565 GO:0001701 GO:0007612 GO:0008285 GO:0060674 GO:0043065 GO:0045787 GO:0008284 GO:0051091 GO:0006357 GO:0051591 GO:0051412 GO:0034097 GO:0042493 GO:0009629 GO:0042542 GO:0009612 GO:0032570 GO:0009615 GO:0006366 GO:0007296
InterPro	IPR000837 IPR004827 IPR029815
PANTHER	PTHR23351 PTHR23351:SF6
Pfam	PF00170
PRINTS	PR00042
SMART	SM00338
PROSITE	PS50217 PS00036

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:2000144	positive regulation of DNA-dependent transcription, initiation	PMID:23027619^[1]	ECO:0000314			P		Measured by luciferase activity, Figure 3C, distinctly demonstrates that FRA-1 up-regulates the transcription of IL-11 over 3 fold.	complete CACAO 7690
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR004827	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:P13346	F		Seeded From UniProt	complete
involved_in	GO:0061614	pri-miRNA transcription by RNA polymerase II	PMID:21673316^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000207870) regulates_transcription_of:(ENSEMBL:ENSG00000270069)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21673316^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSG00000207870) has_direct_input:(ENSEMBL:ENSG00000270069)	Seeded From UniProt	complete
involved_in	GO:2000144	positive regulation of DNA-templated transcription, initiation	PMID:23027619^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0001297 MGI:MGI:102858 MGI:MGI:109384 MGI:MGI:1859147 MGI:MGI:1932093 MGI:MGI:95574 PANTHER:PTN001156258 RGD:1308198 RGD:2626 RGD:2627 RGD:2628 UniProtKB:P01100 UniProtKB:P18847 UniProtKB:P53539 WB:WBGene00001345	C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:109384 MGI:MGI:1859147 MGI:MGI:1932093 MGI:MGI:95574 MGI:MGI:95575 PANTHER:PTN001156258 RGD:2627 UniProtKB:P15407 UniProtKB:Q9NR55	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0051591	response to cAMP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0051412	response to corticosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	C		Seeded From UniProt	complete
part_of	GO:0042734	presynaptic membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	C		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0009629	response to gravity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10158 ensembl:ENSRNOP00000027891	F		Seeded From UniProt	complete
involved_in	GO:0060674	placenta blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48755 ensembl:ENSMUSP00000025850	P		Seeded From UniProt	complete
involved_in	GO:0031668	cellular response to extracellular stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48755 ensembl:ENSMUSP00000025850	P		Seeded From UniProt	complete
involved_in	GO:0007296	vitellogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48755 ensembl:ENSMUSP00000025850	P		Seeded From UniProt	complete
involved_in	GO:0001701	in utero embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48755 ensembl:ENSMUSP00000025850	P		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48755 ensembl:ENSMUSP00000025850	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000837 InterPro:IPR029815	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000837 InterPro:IPR004827	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029815	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004827	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000837 InterPro:IPR029815	P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:8230424^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:8230424^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006968	cellular defense response	PMID:10918580^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:10918580^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006366	transcription by RNA polymerase II	PMID:2107490^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:10918580^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10918580^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10918580^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Shin, SY et al. (2012) Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. Carcinogenesis 33 2467-76 PubMed GONUTS page
↑ ^2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^3.0 ^3.1 Stinson, S et al. (2011) TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. Sci Signal 4 ra41 PubMed GONUTS page
↑ ^4.0 ^4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^5.0 ^5.1 Tsuchiya, H et al. (1993) Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. J. Virol. 67 7001-7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Finzer, P et al. (2000) Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition. Oncogene 19 3235-44 PubMed GONUTS page
↑ Matsui, M et al. (1990) Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. Oncogene 5 249-55 PubMed GONUTS page

[PMID:23027619-1] 1.0 ^1.1 Shin, SY et al. (2012) Transcriptional regulation of the interleukin-11 gene by oncogenic Ras. Carcinogenesis 33 2467-76 PubMed GONUTS page

[PMID:19274049-2] 2.0 ^2.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:21673316-3] 3.0 ^3.1 Stinson, S et al. (2011) TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer. Sci Signal 4 ra41 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8230424-5] 5.0 ^5.1 Tsuchiya, H et al. (1993) Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals. J. Virol. 67 7001-7 PubMed GONUTS page

[PMID:10918580-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Finzer, P et al. (2000) Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition. Oncogene 19 3235-44 PubMed GONUTS page

[PMID:2107490-7] Matsui, M et al. (1990) Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. Oncogene 5 249-55 PubMed GONUTS page

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HUMAN:FOSL1

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