GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:2107490
| Citation |
Matsui, M, Tokuhara, M, Konuma, Y, Nomura, N and Ishizaki, R (1990) Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. Oncogene 5:249-55 |
|---|---|
| Abstract |
cDNA clones of human fos-related genes fra-1 and fra-2 were isolated by screening human c-DNA libraries with human fos DNA as a probe. We obtained human fra-1 cDNA clones that can code for a protein of 271 amino acid residues with a calculated molecular weight of 29,413 and showed 90% similarity with rat fra-1 protein. A new fos-related gene, fra-2, has one long open reading frame of 326 amino acids, and can code for a protein with a calculated molecular weight of 35,193. Two regions, a leucine zipper domain and C-terminal region, are conserved in the fos gene family. The fra-2 gene also harbors these two regions. Transcription of the fos, fra-1 and fra-2 genes was induced by phorbol ester (TPA) stimulation of U937 human monocytic cells. On TPA stimulation, the transcriptions of fos, fra-1 and fra-2 were detectable after 30, 60 and 120 min and maximum after 60, 90 and 240 min, respectively. These findings suggest that expression of the fos gene family is regulated by an orderly mechanism. |
| Links | |
| Keywords |
Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Cell Differentiation; Cell Line; DNA Probes; DNA, Neoplasm/genetics; Gene Expression; Gene Library; Humans; Macrophages/physiology; Molecular Sequence Data; Monocytes/physiology; Nucleic Acid Hybridization; Polymorphism, Genetic; Protein-Tyrosine Kinases/genetics; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins c-fos; Proto-Oncogenes; Rats; Restriction Mapping; Sequence Homology, Nucleic Acid |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006366: transcription by RNA polymerase II |
ECO:0000304: author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
See Help:References for how to manage references in GONUTS.
