HUMAN:KDM5B

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	KDM5B (synonyms: JARID1B, PLU1, RBBP2H1)
Protein Name(s)	Lysine-specific demethylase 5B Cancer/testis antigen 31 CT31 Histone demethylase JARID1B Jumonji/ARID domain-containing protein 1B PLU-1 Retinoblastoma-binding protein 2 homolog 1 RBP2-H1
External Links
UniProt	Q9UGL1
EMBL	AJ132440 AF087481 AJ243706 AC098934 AC104463
CCDS	CCDS30974.1
RefSeq	NP_006609.3
UniGene	Hs.443650
PDB	2MA5 2MNY 2MNZ
PDBsum	2MA5 2MNY 2MNZ
DisProt	DP00712
ProteinModelPortal	Q9UGL1
SMR	Q9UGL1
BioGrid	115984
DIP	DIP-53652N
IntAct	Q9UGL1
STRING	9606.ENSP00000356234
GuidetoPHARMACOLOGY	2681
PhosphoSite	Q9UGL1
DMDM	296439317
MaxQB	Q9UGL1
PaxDb	Q9UGL1
PRIDE	Q9UGL1
Ensembl	ENST00000367264 ENST00000367265
GeneID	10765
KEGG	hsa:10765
UCSC	uc001gyf.3 uc009xag.3
CTD	10765
GeneCards	GC01M202696
H-InvDB	HIX0001478
HGNC	HGNC:18039
HPA	HPA027179
MIM	605393
neXtProt	NX_Q9UGL1
PharmGKB	PA164721626
eggNOG	NOG327026
GeneTree	ENSGT00530000063118
HOGENOM	HOG000290719
InParanoid	Q9UGL1
KO	K11446
OMA	ELMMEAQ
OrthoDB	EOG7D85VK
PhylomeDB	Q9UGL1
TreeFam	TF106476
Reactome	REACT_228178
ChiTaRS	KDM5B
GeneWiki	JARID1B
GenomeRNAi	10765
NextBio	40877
PRO	PR:Q9UGL1
Proteomes	UP000005640
Bgee	Q9UGL1
CleanEx	HS_JARID1B
ExpressionAtlas	Q9UGL1
Genevestigator	Q9UGL1
GO	GO:0005634 GO:0003677 GO:0034648 GO:0034647 GO:0016706 GO:0003700 GO:0003714 GO:0008270 GO:0034720 GO:0034721 GO:0045892 GO:0048511 GO:0006351
Gene3D	1.10.150.60 3.30.40.10
InterPro	IPR001606 IPR003347 IPR003349 IPR013637 IPR019786 IPR004198 IPR011011 IPR001965 IPR019787 IPR013083
Pfam	PF01388 PF02373 PF02375 PF00628 PF08429 PF02928
SMART	SM00501 SM00558 SM00545 SM00249
SUPFAM	SSF46774 SSF57903
PROSITE	PS51011 PS51184 PS51183 PS01359 PS50016

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
	GO:0032453	histone demethylase activity (H3-K4 specific)	PMID:18048344^[1]	ECO:0000314			F	figure 2 shows JARID1B removed H3K4 methylation in vivo. figure shows cell lines that have been with Myc-JARID1B, then immunostained with antibodies specific to methylated lysine residues. The top rows of A,B and C are those that are H3K4, and show cells are not visible in the red stain (the methylated lysine stain), compared to the other stain controls, indicating they have been demethylated.	complete CACAO 7802
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q9Z1N7	F	Seeded From UniProt	complete
enables	GO:0032453	histone demethylase activity (H3-K4 specific)	PMID:28262558^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	PMID:28262558^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:28262558^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:27214403^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	PMID:27214403^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0032453	histone demethylase activity (H3-K4 specific)	PMID:27214403^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:24952722^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	PMID:24952722^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0032453	histone demethylase activity (H3-K4 specific)	PMID:24952722^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:24952722^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20403335^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)	PMID:20403335^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:1990837	sequence-specific double-stranded DNA binding	PMID:20403335^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0032453	histone demethylase activity (H3-K4 specific)	PMID:18048344^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:12657635^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15640446^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	PMID:20228790^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)	PMID:20228790^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)	PMID:20228790^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:12657635^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0035097	histone methyltransferase complex	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104813 PANTHER:PTN000075014	C	Seeded From UniProt	complete
enables	GO:0034647	histone demethylase activity (H3-trimethyl-K4 specific)	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031759 PANTHER:PTN000075015 PomBase:SPAC1002.05c PomBase:SPBP19A11.06 TAIR:locus:2044697 UniProtKB:P29375 UniProtKB:Q9UGL1 WB:WBGene00004319	F	Seeded From UniProt	complete
enables	GO:0032452	histone demethylase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031759 FB:FBgn0033233 FB:FBgn0053182 MGI:MGI:1922855 MGI:MGI:1924054 MGI:MGI:2442355 MGI:MGI:2446210 MGI:MGI:3606484 PANTHER:PTN000075014 PomBase:SPAC1002.05c PomBase:SPBP19A11.06 SGD:S000000971 SGD:S000002503 SGD:S000003880 TAIR:locus:2044697 TAIR:locus:2128659 TAIR:locus:2196979 UniProtKB:B2RXH2 UniProtKB:C8VTU6 UniProtKB:O75164 UniProtKB:O94953 UniProtKB:P29375 UniProtKB:P41229 UniProtKB:Q10RP4 UniProtKB:Q336N8 UniProtKB:Q53WJ1 UniProtKB:Q5N712 UniProtKB:Q6B0I6 UniProtKB:Q9BY66 UniProtKB:Q9H3R0 UniProtKB:Q9UGL1 WB:WBGene00004319 WB:WBGene00012982	F	Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000075014 PomBase:SPAC1002.05c PomBase:SPAC343.11c PomBase:SPBP19A11.06	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0031759 FB:FBgn0033233 FB:FBgn0036004 FB:FBgn0053182 MGI:MGI:104813 MGI:MGI:2136980 MGI:MGI:3606484 MGI:MGI:99781 PANTHER:PTN000075014 PomBase:SPBP19A11.06 RGD:1306378 RGD:1588576 SGD:S000002503 TAIR:locus:2128659 TAIR:locus:2146653 TAIR:locus:504955644 UniProtKB:B2RXH2 UniProtKB:O75164 UniProtKB:O94953 UniProtKB:P29375 UniProtKB:P41229 UniProtKB:Q53WJ1 UniProtKB:Q5N712 UniProtKB:Q92833 UniProtKB:Q9UGL1 WB:WBGene00004319	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0034647	P	Seeded From UniProt	complete
involved_in	GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0034647	P	Seeded From UniProt	complete
involved_in	GO:0034721	histone H3-K4 demethylation, trimethyl-H3-K4-specific	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0034647	P	Seeded From UniProt	complete
involved_in	GO:2000864	regulation of estradiol secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:1990830	cellular response to leukemia inhibitory factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:0061038	uterus morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:0060763	mammary duct terminal end bud growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:0060444	branching involved in mammary gland duct morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:0033601	positive regulation of mammary gland epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
enables	GO:0032453	histone demethylase activity (H3-K4 specific)	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	F	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:0007338	single fertilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q80Y84 ensembl:ENSMUSP00000038138	P	Seeded From UniProt	complete
involved_in	GO:0070306	lens fiber cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K6G9 ensembl:ENSRNOP00000073808	P	Seeded From UniProt	complete
involved_in	GO:0060992	response to fungicide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K6G9 ensembl:ENSRNOP00000073808	P	Seeded From UniProt	complete
involved_in	GO:0044344	cellular response to fibroblast growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K6G9 ensembl:ENSRNOP00000073808	P	Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001606 InterPro:IPR036431	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12657635^[6] PMID:10336460^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10336460^[10]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	Reactome:R-HSA-8866911	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8865280 Reactome:R-HSA-8865265 Reactome:R-HSA-5661116 Reactome:R-HSA-4754181	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0051213	dioxygenase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0223	F	Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P	Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F	Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P	Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P	Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Xiang, Y et al. (2007) JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc. Natl. Acad. Sci. U.S.A. 104 19226-31 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Tumber, A et al. (2017) Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol 24 371-380 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Johansson, C et al. (2016) Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat. Chem. Biol. 12 539-45 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Zhang, Y et al. (2014) The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell 5 837-50 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Yao, W et al. (2010) The flexible loop L1 of the H3K4 demethylase JARID1B ARID domain has a crucial role in DNA-binding activity. Biochem. Biophys. Res. Commun. 396 323-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Tan, K et al. (2003) Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. J. Biol. Chem. 278 20507-13 PubMed GONUTS page
↑ Patsialou, A et al. (2005) DNA-binding properties of ARID family proteins. Nucleic Acids Res. 33 66-80 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Metzger, E et al. (2010) Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature 464 792-6 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^10.0 ^10.1 Lu, PJ et al. (1999) A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J. Biol. Chem. 274 15633-45 PubMed GONUTS page

[PMID:18048344-1] 1.0 ^1.1 Xiang, Y et al. (2007) JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc. Natl. Acad. Sci. U.S.A. 104 19226-31 PubMed GONUTS page

[PMID:28262558-2] 2.0 ^2.1 ^2.2 Tumber, A et al. (2017) Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol 24 371-380 PubMed GONUTS page

[PMID:27214403-3] 3.0 ^3.1 ^3.2 Johansson, C et al. (2016) Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat. Chem. Biol. 12 539-45 PubMed GONUTS page

[PMID:24952722-4] 4.0 ^4.1 ^4.2 ^4.3 Zhang, Y et al. (2014) The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell 5 837-50 PubMed GONUTS page

[PMID:20403335-5] 5.0 ^5.1 ^5.2 Yao, W et al. (2010) The flexible loop L1 of the H3K4 demethylase JARID1B ARID domain has a crucial role in DNA-binding activity. Biochem. Biophys. Res. Commun. 396 323-8 PubMed GONUTS page

[PMID:12657635-6] 6.0 ^6.1 ^6.2 Tan, K et al. (2003) Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. J. Biol. Chem. 278 20507-13 PubMed GONUTS page

[PMID:15640446-7] Patsialou, A et al. (2005) DNA-binding properties of ARID family proteins. Nucleic Acids Res. 33 66-80 PubMed GONUTS page

[PMID:20228790-8] 8.0 ^8.1 ^8.2 Metzger, E et al. (2010) Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4. Nature 464 792-6 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10336460-10] 10.0 ^10.1 Lu, PJ et al. (1999) A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer. J. Biol. Chem. 274 15633-45 PubMed GONUTS page

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HUMAN:KDM5B

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References

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